diffusion MRI of neurodegenerative disorders: mapping to biomarker
Project/Area Number |
25461848
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Juntendo University |
Principal Investigator |
Aoki Shigeki 順天堂大学, 医学部, 教授 (80222470)
|
Co-Investigator(Kenkyū-buntansha) |
寺田 一志 東邦大学, 医学部, 教授 (90227520)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 放射線医学 / MRI / 拡散MRI / 拡散テンソル画像 / DTI / 拡散尖度画像 / DKI / 神経変性疾患 / 脳変性疾患 / パーキンソン病 / 正常圧水頭症 / 次世代拡散MRI / 拡散kurtosis画像 / 拡散による微細構造解析 / diffusion tensor imaging / NODDI / NPH / 拡散テンソル DTI / connectome / 脳 / diffusion MRI / diffusional kurtosis / Q space imaging / multiband EPI / Parkinson disease / spinocerebellar ataxia |
Outline of Final Research Achievements |
The diffusion magnetic resonance imaging(dMRI) provides indispensable clinical information and can also uniquely visualize and analyze the white matter and its structural connectivity of the brain. Diffusion tensor imaging(DTI) can visualize the white matter tracts in vivo, which has never seen before. Non-Gaussian diffusion analysis, next generation of dMRI, is recently highlighted to analyze precise microstructures. We studied DTI, diffusional Kurtosis imaging (DKI), Q-space imaging and neurite orientation dispersion and density imaging (NODDI) for possible candidate of imaging biomarker for neurodegenerative disorders. Changes of diffusion parameters such as mean diffusional kurtosis (DKI) were observed in several disease-specific areas. We think dMRI will become a good imaging biomarker in many neurodegenerative disorders.
|
Report
(5 results)
Research Products
(46 results)
-
[Journal Article] Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus.2017
Author(s)
Kouhei Kamiya, Masaaki Hori, Ryohei Irie, Masakazu Miyajima, Madoka Nakajima, Koji Kamagata, Kouhei Tsuruta, Asami Saito, Misaki Nakazawa, Yuichi Suzuki, Harushi Mori, Akira Kunimatsu, Hajime Arai
-
Journal Title
NeuroImage: Clinical
Volume: 14
Pages: 663-671
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Neurite Orientation Dispersion and Imaging for Evaluation of Corticospinal Tract in Idiopathic Normal Pressure Hydrocephalus2017
Author(s)
Ryusuke Irie, Kohei Tsuruta, Masaaki Hori, Michimasa Suzuki, Koji Kamagata, Atsushi Nakanishi, Kouhei Kamiya, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Shigeki Aoki
-
Journal Title
Jpn J Radiol
Volume: 35
Issue: 1
Pages: 25-30
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Diffusional Kurtosis Imaging in Idiopathic Normal Pressure Hydrocephalus: Correlation with Severity of Cognitive Impairment2016
Author(s)
Kamiya K, Kamagata K, Miyajima M, Nakajima M, Hori M, Tsuruta K, Mori H, Kunimatsu A, Arai H, Aoki S, Ohtomo K.
-
Journal Title
Magnetic Resonance in Medical Sciences
Volume: 15
Issue: 3
Pages: 316-323
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] Diffusional Kurtosis Imaging in Idiopathic Normal Pressure Hydrocephalus: Correlation with Severity of Cognitive Impairment.2016
Author(s)
Kamiya K, Kamagata K, Miyajima M, Nakajima M, Hori M, Tsuruta K, Mori H,Kunimatsu A, Arai H, Aoki S, Ohtomo K.
-
Journal Title
Magn Reson Med Sci.
Volume: 16
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Prospective estimation of mean axon diameter and extra-axonal space of the posterior limb of the internal capsule in patients with idiopathic normal pressure hydrocephalus before and after a lumboperitoneal shunt by using q-space diffusion MRI.2016
Author(s)
Hori M, Kamiya K, Nakanishi A, Fukunaga I, Miyajima M, Nakajima M, Suzuki M,Suzuki Y, Irie R, Kamagata K, Arai H, Aoki S.
-
Journal Title
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Dural Enhancement in a Patient with Sturge-Weber Syndrome Revealed by Double Inversion Recovery Contrast Using Synthetic MRI2016
Author(s)
Hagiwara A, Nakazawa M, Andica C, Tsuruta K, Takano N, Hori M, Suzuki H, Sugano H, Arai H, Aoki S.
-
Journal Title
Magnetic Resonance in Medical Sciences
Volume: 15
Issue: 2
Pages: 151-152
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Prospective estimation of mean axon diameter and extra-axonal space of the posterior limb of the internal capsule in patients with idiopathic normal pressure hydrocephalus before and after a lumboperitoneal shunt by using q-space diffusion MRI.2015
Author(s)
Masaaki Hori, Kouhei Kamiya, Atsushi Nakanishi, Issei Fukunaga, Masakazu Miyajima, Madoka Nakajima, Michimasa Suzuki, Yuriko Suzuki, Ryosuke Irie, Koji Kamagata, Hajime Arai, Shigeki Aoki
-
Journal Title
Europin Radiology
Volume: E-pub
Issue: 9
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease.2015
Author(s)
Kamagata K, Hatano T, Okuzumi A, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
-
Journal Title
Eur Radiol.
Volume: Oct
Issue: 8
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Diffusion-tensor-based method for robust and practical estimation of axial and radial diffusional kurtosis.2015
Author(s)
Tachibana Y, Obata T, Tsuchiya H, Omatsu T, Kishimoto R, Kawaguchi H, Nishikori A, Kamagata K, Hori M, Aoki S, Tsuji H, Inoue T.
-
Journal Title
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease.2015
Author(s)
Kamagata K, Hatano T, Okuzumi A, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
-
Journal Title
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter2014
Author(s)
Masaaki Hori, Mariko Yoshida, Kazumasa Yokoyama, Koji Kamagata, Fumitaka Kumagai, Issei Fukunaga , Kouhei Kamiya, Michimasa Suzuki, Yoshitaka Masutani, Nozomi Hamasaki ,Yuriko Suzuki, Shinsuke Kyogoku, Nobutaka Hattori, Shigeki Aoki
-
Journal Title
Magn Reson Imaging.
Volume: Mar 18.
Issue: 6
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
[Journal Article] Structural brain abnormalities in women with subclinical depression, as revealed by voxel-based morphometry and diffusion tensor imaging.2013
Author(s)
Hayakawa, YK, Sasaki, H, Takao, H, Mori H, Hayashi N, Kunimatsu A, Aoki S, Ohtomo K
-
Journal Title
Journal of Affective disorders
Volume: 144
Pages: 263-268
Related Report
Peer Reviewed
-
-
[Journal Article] Effects of diffusional kurtosis imaging parameters on diffusion quantification2013
Author(s)
Fukunaga I, Hori M, Masutani Y, Hamasaki N, Sato S, Suzuki Y, Kumagai F, Kosuge M, Hoshito H, Kamagata K, Shimoji K, Nakanishi A, Aoki S, Senoo A.
-
Journal Title
Radiol Phys Technol
Volume: 6
Issue: 2
Pages: 343-348
DOI
Related Report
Peer Reviewed
-
[Presentation] Diffusion tensor imaging and ventricular volumetry in idiopathic normal pressure hydrocephalus: relationships between cognitive deterioration before and after a lumboperitoneal shunt.2017
Author(s)
Asami Saito, Koji Kamagata, Ryo Ueda, Misaki Nakazawa, Christina Andica, Sho Murata, Madoka Nakajima, Masakazu Miyanaga, Kouhei Kamiya Masaaki Hori, Kanako K Kumamaru, Michimasa Suzuki, Hajime Arai, Shigeki Aoki
Organizer
The 5th International Congress on Magnetic Resonance Imaging (ICMRI2017) & 22nd Annual Scientific Meeting of KSMRM,
Place of Presentation
Seoul, Korea
Year and Date
2017-03-23
Related Report
Int'l Joint Research
-
-
[Presentation] LPシャント術前後のiNPHの脳室体積測定と拡散テンソルトラクトグラフィ解析2016
Author(s)
斎藤麻美, 鎌形康司, 上田亮, 中澤美咲, アンディカクリスティナ, 村田渉, 中島円, 宮嶋雅一, 神谷昴平, 堀正明, 隈丸加奈子, 鈴木通真, 新井一, 青木茂樹
Organizer
第44回日本磁気共鳴医学会大会,
Place of Presentation
大宮
Year and Date
2016-09-09
Related Report
-
[Presentation] パーキンソン病の黒質線条体神経線維の神経突起イメージングによる評価2016
Author(s)
中澤美咲, アンディカクリスティナ, 鎌形康司, 上田亮, 波田野琢, 奥住文美, 阿部修, 鈴木通真, 堀正明, 隈丸加奈子, 服部信孝, 青木茂樹
Organizer
第44回日本磁気共鳴医学会大会,
Place of Presentation
大宮
Year and Date
2016-09-09
Related Report
-
-
[Presentation] Alteration of White Matter Microstructure Within the Reward Circuit Revealed by Neurite Orientation Dispersion and Density Imaging (NODDI)2016
Author(s)
・Kamiya K, Okada N, Suzuki Y, Irie R, Kubo T, Nakai Y, Nippashi Y, Koshiyama D, Morita K, Sawada K, Satomura Y, Koike S, Mori H, Kunimatsu A, Kasai K, Ohtomo K.
Organizer
ISMRM 24th Annual Meeting & Exhibition, Suntec City,
Place of Presentation
Singapore
Year and Date
2016-05-10
Related Report
Int'l Joint Research
-
-
-
[Presentation] Contrast-enhanced Synthetic MRI for the Detection of Brain Metastases2015
Author(s)
3.Akifumi Hagiwara, Christina Andica, Masaaki Hori, Saori Shiota, Mariko Yoshida, Kanako Sato, Yuko Adachi, Kanako Kumamaru, Michimasa Suzuki, Atsushi Nakanishi, Misaki Nakazawa, Kouhei Tsuruta, Shigeki Aoki
Organizer
AOCNR 10th
Place of Presentation
Fukuoka
Year and Date
2015-11-05
Related Report
Int'l Joint Research
-
-
-
[Presentation] Diffusional kurotsis imaging and cognitive disturbance in idiopathic normal pressure hydrocephalus. RSNA 2014 annual meeting2014
Author(s)
Kouhei Kamiya, Koji Kamagata, Akira Nishikori, Ryusuke Irie, Masaaki Hori, Masakazu Miyajima, Madoka Nakajima, Harushi Mori, Akira Kunimatsu, Hajime Arai, Shigeki Aoki, Kuni Ohtomo.
Organizer
RSNA
Place of Presentation
Chiccago, USA
Year and Date
2014-11-30 – 2014-12-05
Related Report
-
-
-
[Presentation] Preliminary Diffusional Kurtosis Imaging of the substantia nigra in de novo Parkinson disease: Diagnostic Utility of Histogram Analysis: ISMRM 22nd annual meeting2014
Author(s)
Koji Kamagata, Masaaki Hori, Kohei Kamiya, Michimasa Suzuki, Akira Nishikori, Mariko Yoshida, Fumitaka Kumagai, Taku Hatano, Hiroyuki Tomiyama, Nobutaka Hattori, Shigeki Aok
Organizer
ISMRM
Place of Presentation
Milan, Italy
Year and Date
2014-05-10 – 2014-05-16
Related Report
-
[Presentation] 帯状束の拡散パラメータ測定によるAD、DLBの鑑別
Author(s)
小菅正嗣,鎌形康司,本井ゆみ子,堀正明,増谷佳孝,福永一星,濱崎望,下地啓吾,鈴木通真,鈴木由里子,佐藤秀二,吉田茉莉子,青木茂樹,服部信孝,妹尾淳史
Organizer
第41回日本磁気共鳴医学会大会
Place of Presentation
徳島
Related Report
-
-