Multifaced imaging analysis in patients with intractable epilepsy: a study for surgical treatment approach

• Project/Area Number: 25461865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Sato Noriko 国立研究開発法人国立精神・神経医療研究センター, 病院 放射線診療部, 部長 (10322017)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Masayuki 国立精神・神経医療研究センター病院, 小児神経診療部, 部長 (60235273)
• Research Collaborator: SONE Daichi ; KIMURA Yukio
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: てんかん / 画像解析 / MRI / DTI / epilepsy / MR / PET / 画像統計解析 / 限局性皮質異型性 / SPECT

Outline of Final Research Achievements

Multifaced imaging analyze was done in patients with intractable epilepsy. Ipsilateral temporal cortex was thickened in 60% temporal epilepsy (TLE) patients with amygdala enlargement, whose pathology was proved to be cortical dysplasia. The white matter volume and FA value were significantly decreased in patients with TLE with hippocampal sclerosis comparing to TLE with amygdala enlargement. These results showed that the etiology was different between them. Subfield volumetric analysis using high resolution T2WI demonstrated decreased volume of C1, C4, and dentate nucleus in patients with hippocampal sclerosis. Graph analysis detected cerebral fragility at temporooccipital and lateral frontal lobes in patients with idiopathic generalized epilepsy. These methods seem to be useful for speculating their pathology and planning their treatments.

Research Products

• [Journal Article] Noninvasive evaluation of the correlation between regional cerebral blood flow and intraventricular brain temperature in temporal lobe epilepsy. (2016)
  • Author(s): Sone D, Ota M, Yokoyama K, Sumida K, Kimura Y, Imabayashi E, Matsuda H, Sato N.
  • Journal Title: Magn Reson Imaging Volume: 34(4) Issue: 4 Pages: 451-454
  • DOI: 10.1016/j.mri.2015.12.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Graph Theoretical Analysis of Structural Neuroimaging in Temporal Lobe Epilepsy with and without Psychosis. (2016)
  • Author(s): Sone D, Matsuda H, Ota M, Maikusa N, Kimura Y, Sumida K, Yokoyama K, Imabayashi E, Watanabe M, Watanabe Y, Okazaki M, Sato N.
  • Journal Title: PLoS One. Volume: 11(7) Issue: 7 Pages: e0158728-e0158728
  • DOI: 10.1371/journal.pone.0158728
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Automated subfield volumetric analysis of hippocampus in temporal lobe epilepsy using high-resolution T2-weighed MR imaging. (2016)
  • Author(s): Sone D, Sato N, Maikusa N, Ota M, Sumida K, Yokoyama K, Kimura Y, Imabayashi E, Watanabe Y, Watanabe M, Okazaki M, Onuma T, Matsuda H.
  • Journal Title: Neuroimage Clin. Volume: 12 Pages: 57-64
  • DOI: 10.1016/j.nicl.2016.06.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] White matter abnormalities in patients with temporal lobe epilepsy and amygdala enlargement: Comparison with hippocampal sclerosis and healthy subjects. (2016)
  • Author(s): Sone D, Ota M, Maikusa N, Kimura Y, Sumida K, Yokoyama K, Imabayashi E, Watanabe M, Watanabe Y, Okazaki M, Sato N, Matsuda H.
  • Journal Title: Epilepsy Res. Volume: 127 Pages: 221-228
  • DOI: 10.1016/j.eplepsyres.2016.09.011
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Striatal glucose hypometabolism in preadolescent-onset dentatorubral-pallidoluysian atrophy. (2016)
  • Author(s): Sone D, Sato N, Yokoyama K, Sumida K, Kanai M, Imabayashi E, Saito Y, Matsuda H.
  • Journal Title: J Neurol Sci. Volume: 360 Pages: 121-124
  • DOI: 10.1016/j.jns.2015.12.002
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of amygdala pathology using 11C-methionine positron emission tomography/computed tomography in patients with temporal lobe epilepsy and amygdala enlargement. (2015)
  • Author(s): Sone D, Ito K, Taniguchi G, Murata Y, Nakata Y, Wanatabe Y, Okazaki M, Sato N, Matsuda H, Watanabe M.
  • Journal Title: Epilepsy Res. Volume: 112 Pages: 114-121
  • DOI: 10.1016/j.eplepsyres.2015.02.018
  • Peer Reviewed / Open Access
• [Journal Article] White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study (2015)
  • Author(s): Ota M, Noda T, Sato N, Hattori K, Hori H, Sasayama D, Teraishi T, Nagashima A, Obu S, Higuchi T, Kunugi H
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 印刷中 Issue: 6 Pages: 360-368
  • DOI: 10.1111/pcn.12255
  • Peer Reviewed / Open Access
• [Presentation] Novel susceptibility-weighted imaging finding of a “low-signal-intensity rim” along the deep layers of the cerebral cortex in a spectrum of central nervous system diseases. (2016)
  • Author(s): Umino M, Maeda M, Sakuma H, Sumida K, Sato N
  • Organizer: 2016 Radiological Society of North America.
  • Place of Presentation: シカゴ
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] 難治てんかんで発症した Rosette-forming glioneuronal tumor の1例 (2016)
  • Author(s): 住友典子,中川栄二,石山昭彦,竹下絵里,本橋裕子,齋藤貴志,小牧宏文,須貝研司,高橋章夫,大槻泰介,佐藤典子,澁谷誠,齊藤祐子,佐々木征行
  • Organizer: 多摩神経懇話会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-16
• [Book] 希少てんかんの診療指標 (2017)
  • Author(s): 佐藤典子,松田博史
  • Total Pages: 276
  • Publisher: 診断と治療社