| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Multifaced imaging analyze was done in patients with intractable epilepsy. Ipsilateral temporal cortex was thickened in 60% temporal epilepsy (TLE) patients with amygdala enlargement, whose pathology was proved to be cortical dysplasia. The white matter volume and FA value were significantly decreased in patients with TLE with hippocampal sclerosis comparing to TLE with amygdala enlargement. These results showed that the etiology was different between them. Subfield volumetric analysis using high resolution T2WI demonstrated decreased volume of C1, C4, and dentate nucleus in patients with hippocampal sclerosis. Graph analysis detected cerebral fragility at temporooccipital and lateral frontal lobes in patients with idiopathic generalized epilepsy. These methods seem to be useful for speculating their pathology and planning their treatments.
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