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CT-guided radiofrequency ablation with chemotherapy in a rabbit VX2 lung tumor model

Research Project

Project/Area Number 25461887
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka City University

Principal Investigator

Okuma Tomohisa  大阪市立大学, 大学院医学研究科, 講師 (50445029)

Research Collaborator HAMAMOTO Shinichi  大阪市立大学, 大学院医学研究科, 講師 (80711788)
UEKI Ai  大阪市立大学, 大学院医学研究科, 後期臨床研究医 (30551155)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsラジオ波凝固療法 / 癌 / ラジオ波治療
Outline of Final Research Achievements

The results of the present study show that the combination of radiofrequency ablation (RFA) and cisplatin (CDDP)/paclitaxel (PTX) treatment had a significant survival benefit compared to control (without treatment), CDDP/PTX alone or RFA treatment alone in a rabbit lung cancer model with a VX2 tumor. In contrast, treatment with a combination of RFA and CDDP/vinorelbine (VNR) or CDDP/pemetrexed (MTA) chemotherapy did not show any survival benefit compared to the control or the platinum doublet alone chemotherapy and resulted in significantly shorter survival compared to RFA treatment alone.
The combination of RFA and systemic platinum-doublet chemotherapy with cisplatin/paclitaxel may improve the local control rate and prolong survival.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Life-threatening and Rapidly Growing Teratoma in the Anterior Mediastinum2015

    • Author(s)
      Omachi N, Kawaguchi T, Shimizu S, Okuma T, Kitaichi M, Atagi S, Yoon HE, Matsumura A.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 19 Pages: 2487-2489

    • DOI

      10.2169/internalmedicine.54.4622

    • NAID

      130005101801

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy2015

    • Author(s)
      Maekura T, Shimizu S, Kawaguchi T, Morimoto M, Okuma T, Matsui H, Atagi S.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 9 Pages: 1095-1098

    • DOI

      10.2169/internalmedicine.54.3624

    • NAID

      130005068334

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination Radiofrequency Ablation and Local Injection of the Immunostimulant Bacillus Calmette-Guérin Induces Antitumor Immunity in the Lung and at a Distant VX2 Tumor in a Rabbit Model.2015

    • Author(s)
      Hamamoto S, Okuma T, Yamamoto A, Kageyama K, Ueki A, Matsuoka T, Miki Y.
    • Journal Title

      J Vasc Interv Radiol.

      Volume: 26 Issue: 2 Pages: 271-278

    • DOI

      10.1016/j.jvir.2014.09.002

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Small calcifying fibrous pseudotumor of the heart confined to the epicardium.2015

    • Author(s)
      Shimizu S, Funakoshi Y, Yoon HE, Okuma T, Utsumi T, Ito N, Sakaguchi M, Taniguchi K, Eimoto T, Matsumura A.
    • Journal Title

      Cardiovasc Pathol.

      Volume: 24 Issue: 3 Pages: 191-193

    • DOI

      10.1016/j.carpath.2014.11.003

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effective palliative radiofrequency ablation for tumors causing pain, numbness and motor function disorders: case series.2014

    • Author(s)
      Hamamoto S, Matsuoka T, Okuma T, Yamamoto A, Hamuro M, Miki Y.
    • Journal Title

      BMC Res Notes.

      Volume: 7 Issue: 1 Pages: 765-765

    • DOI

      10.1186/1756-0500-7-765

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictors of the clinical effects of pirfenidone on idiopathic pulmonary fibrosis2014

    • Author(s)
      Arai T, Inoue Y, Sasaki Y, Tachibana K, Nakao K, Sugimoto C, Okuma T, Akira M, Kitaichi M, Hayashi S
    • Journal Title

      Respir Investig

      Volume: 52 Issue: 2 Pages: 136-43

    • DOI

      10.1016/j.resinv.2013.09.002

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Utility of expiratory thin-section CT for fibrotic interstitial pneumonia.2014

    • Author(s)
      Tokura S. Okuma T et al
    • Journal Title

      Acta Radiol

      Volume: 55 Issue: 9 Pages: 1050-1055

    • DOI

      10.1177/0284185113512300

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utility of expiratory thin-section CT for fibrotic interstitial pneumonia.2014

    • Author(s)
      Tokura S, Okuma T, Akira M, Arai T, Inoue Y, Kitaichi M.
    • Journal Title

      Acta Radiol.

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation of liver tumors in combination with local OK-432 injection prolongs survival and suppresses distant tumor growth in the rabbit model with intra- and extrahepatic VX2 tumors.2013

    • Author(s)
      Kageyama K, Yamamoto A, Okuma T, Hamamoto S, Takeshita T, Sakai Y, Nishida N, Matsuoka T, Miki Y.
    • Journal Title

      Cardiovasc Intervent Radiol.

      Volume: 36 Issue: 5 Pages: 1383-1392

    • DOI

      10.1007/s00270-013-0650-y

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency Ablation and Immunostimulant OK-432: Combination Therapy Enhances Systemic Antitumor Immunity2013

    • Author(s)
      Shinichi Hamamoto, Tomohisa Okuma et al
    • Journal Title

      Radiology 120249; Published online February 25, 2013

      Volume: in press Issue: 2 Pages: 405-413

    • DOI

      10.1148/radiol.13120249

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 当院の肺腫瘍に対するCTガイド下ラジオ波凝固療法の成績2013

    • Author(s)
      大隈智尚
    • Organizer
      第54回日本肺癌学会総会
    • Place of Presentation
      東京 ホテルニューオータニ東京 〒102-8578 東京都千代田区紀尾井町4-1
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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