To investigate the clinical application of alpha-defensin in stool in the objective evaluation of radiation enteritis
| Project/Area Number |
25461899
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido Cancer Center(Department of Clinical Research) (2014-2015)
Hokkaido University (2013) |
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Principal Investigator |
Onodera Shunsuke 独立行政法人国立病院機構北海道がんセンター(臨床研究部), その他部局等, その他 (30374458)
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| Co-Investigator(Kenkyū-buntansha) |
Nakamura Kiminori 北海道大学, 大学院先端生命科学研究院自然免疫研究室, 准教授 (80381276)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 放射線腸炎 / α-defensin / 腸内細菌叢 / αディフェンシン / 強度変調放射線治療 / 陽子線治療 / 放射線性腸炎 / αdefensin / 血中シトルリン |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the clinical application of α-defensin in stool in the objective evaluation of radiation enteritis.As the first step, we experimented on mice and found that the amount of α-defensin significantly decreased in stool of mice irradiated to the abdomen.In addition, a significant negative correlation was observed between the amount of α-defensin and Firmicutes at three days after irradiation.These results suggested that decrease of α-defensin correlated with an altered intestinal flora of the mice irradiated to the abdomen.We could not investigate the clinical application due to insufficient number of patients in this period.
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Report
(4 results)
Research Products
(5 results)
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[Presentation] NTCP Modeling Analysis of Acute Hematologic Toxicity in Whole Pelvic Radiation Therapy for Gynecologic Malignancies - A Dosimetric Comparison of IMRT and Spot-Scanning Proton Therapy2015
Author(s)
T.Yoshimura, R.Kinoshita, S.Onodera, C.Toramatsu, R.Suzuki, Y.M.Ito, S.Takao, T.Matsuura, Y.Matsuzaki, S.Shimizu, K.Umegaki, H.Shirato
Organizer
57th Annual Meeting of ASTRO
Place of Presentation
San Antonio, USA
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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