| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the clinical application of α-defensin in stool in the objective evaluation of radiation enteritis.As the first step, we experimented on mice and found that the amount of α-defensin significantly decreased in stool of mice irradiated to the abdomen.In addition, a significant negative correlation was observed between the amount of α-defensin and Firmicutes at three days after irradiation.These results suggested that decrease of α-defensin correlated with an altered intestinal flora of the mice irradiated to the abdomen.We could not investigate the clinical application due to insufficient number of patients in this period.
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