The study to develop the irradiation method to improve the curability for high-grade malignant glioma
Project/Area Number |
25461929
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Nippon Medical School (2016) Tokyo Women's Medical University (2013-2015) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
新田 雅之 東京女子医科大学, 医学部, 助教 (70588269)
中村 香織 東京女子医科大学, 医学部, 助教 (40339023)
河野 佐和 東京女子医科大学, 医学部, 医療練士研修生 (80645820)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 高悪性度神経膠腫 / 膠芽腫 / 放射線治療 / 強度変調放射線治療 / 分子生物学的予後因子 / 悪性神経膠腫 / 放射線抵抗性 / 新規照射法の開発 / 放射線治療法 |
Outline of Final Research Achievements |
For the cure rate improvement of the poor-prognosis high-grade glioma "leading a factor to decide the most suitable irradiation method" of this study was intended. I evaluated the recurrence part and pattern with the treatment planning systems / analytical devices exactly and checked the relationships with the administrated dose. In Grade 4, the recurrence occurred from the range where 50 to 60 Gy were administered in most cases, and various investigations were performed, although factors considered to be useful could not be derived. In Grade3, I thought that a follow-up period was insufficient, I postponed that I gave a conclusion. On the other hand, I examined the relationship of the molecular biologic prognostic factors and the recurrence part/pattern, and as a result, I recognized a difference for a treatment result in 1p/19qLOH of Grade3 and in IDH-1 of Grade4. For this result, the postoperative treatment methods will need the examination from a different viewpoint.
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] Proposed therapeutic strategy for adult low-grade glioma based on aggressive tumor resection.2015
Author(s)
Nitta M, Muragaki Y, Maruyama T, Ikuta S, Komori T, Maebayashi K, Iseki H, Tamura M, Saito T, Okamoto S, Chernov M, Hayashi M, Okada Y.
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Journal Title
Neurosurg Focus
Volume: 38(1)
Issue: 1
Pages: E7-E7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phase II clinical study on intraoperative photodynamic therapy with2013
Author(s)
Muragaki Y1, Akimoto J, Maruyama T, Iseki H, Ikuta S, Nitta M, Maebayashi K, Saito T, Okada Y, Kaneko S, Matsumura A, Kuroiwa T, Karasawa K, Nakazato Y, Kayama T.
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Journal Title
J Neurosurg.
Volume: 119
Pages: 845-852
Related Report
Peer Reviewed
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[Presentation] 有害事象:脳2016
Author(s)
前林勝也
Organizer
日本放射線腫瘍学会第29回学術大会
Place of Presentation
京都
Year and Date
2016-11-25
Related Report
Invited
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[Presentation] 脳腫瘍の放射線治療2015
Author(s)
前林勝也
Organizer
日本放射線腫瘍学会第28回学術大会
Place of Presentation
ベイシア文化ホール、前橋市
Year and Date
2015-11-19
Related Report
Invited
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[Presentation] RadioTherapy ; IMRT2015
Author(s)
Katsuya Maebayashi, Sachiko Izumi, Yaichiro Hashimoto, Sawa Kono, Yuka Ishii, Ikuta Souko, Takashi Maruyama, Yoshihiro Muragaki, Kumiko Karasawa
Organizer
第74回日本医学放射線学会総会
Place of Presentation
パシフィコ横浜、横浜市
Year and Date
2015-04-16
Related Report
Invited
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[Presentation] 脳腫瘍2014
Author(s)
前林勝也
Organizer
日本放射線腫瘍学会 夏季セミナー
Place of Presentation
日光東照宮(栃木県・日光市)
Year and Date
2014-08-30 – 2014-08-31
Related Report
Invited
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