2016 Fiscal Year Final Research Report
The study to develop the irradiation method to improve the curability for high-grade malignant glioma
Project/Area Number |
25461929
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Nippon Medical School (2016) Tokyo Women's Medical University (2013-2015) |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Keywords | 高悪性度神経膠腫 / 膠芽腫 / 放射線治療 / 強度変調放射線治療 / 分子生物学的予後因子 |
Outline of Final Research Achievements |
For the cure rate improvement of the poor-prognosis high-grade glioma "leading a factor to decide the most suitable irradiation method" of this study was intended. I evaluated the recurrence part and pattern with the treatment planning systems / analytical devices exactly and checked the relationships with the administrated dose. In Grade 4, the recurrence occurred from the range where 50 to 60 Gy were administered in most cases, and various investigations were performed, although factors considered to be useful could not be derived. In Grade3, I thought that a follow-up period was insufficient, I postponed that I gave a conclusion. On the other hand, I examined the relationship of the molecular biologic prognostic factors and the recurrence part/pattern, and as a result, I recognized a difference for a treatment result in 1p/19qLOH of Grade3 and in IDH-1 of Grade4. For this result, the postoperative treatment methods will need the examination from a different viewpoint.
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Free Research Field |
放射線医学
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