Simultaneous-integrated boost intensity-modulated radiotherapy for pelvic cnacer

• Project/Area Number: 25461931
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka Medical College
• Principal Investigator: YOSHIDA KEN 大阪医科大学, 医学部, 講師 (10463291)
• Co-Investigator(Kenkyū-buntansha): 上田 麻里 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (00626773) ; 古妻 理之 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (00641870) ; 田中 英一 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (10324774) ; 隅田 伊織 大阪大学, 医学系研究科, 助教 (10425431) ; 新保 大樹 大阪医科大学, 医学部, 助教 (30535018) ; 山崎 秀哉 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50301263) ; 上杉 康夫 大阪医科大学, 医学部, 非常勤講師 (80223452) ; 武中 正 独立行政法人国立病院機構姫路医療センター(臨床研究部), その他部局等, 研究員 (80626771) ; 鳴海 善文 大阪医科大学, 医学部, 教授 (90273664) ; 三宅 俊輔 独立行政法人国立病院機構大阪医療センター(臨床研究センター), 放射線科, 研究員 (90626772)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 放射線治療 / 小線源治療 / 画像誘導 / 高線量率小線源治療 / 医学物理 / リアルタイム実測 / 3次元画像誘導治療計画 / 強度変調 / 標的体積内ブースト / 化学線量計 / 適切なモダリティー / 標的体積内同時ブースト

Outline of Final Research Achievements

To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis (Brachytherapy 2016;15:57-64). Before we start simultaneous integrated boost intensity modulated brachytherapy for pelvic cancer, we analyzed the treatment results of our image-guided brachytherapy for uterine cancer (Brachytherapy 2015;14:1-8, 2015;14:440-8). We started to evaluate the effectiveness of plastic scintillation fiber in order to measure the irradiateddoses during brachytherapy as a real-time in vivo dosimetry.

Research Products

• [Journal Article] Edema worsens target coverage in high-dose-rate interstitial brachytherapy of mobile tongue cancer: a report of two cases. (2017)
  • Author(s): Yoshida K, Yamazaki H, Kotsuma T, Akiyama H, Takenaka T, Masui K, Yoshioka Y, Uesugi Y, Shimbo T, Yoshikawa N, Yoshioka H, Arika T, Tanaka E, Narumi Y.
  • Journal Title: J Contemp Brachytherapy Volume: 9 Pages: 66-70
  • DOI: 10.5114/jcb.2017.65163
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium. (2017)
  • Author(s): Ishiyama H, Kamitani N, Kawamura H, Kato S, Aoki M, Kariya S, Matsumura T, Kaidu M, Yoshida K, Hashimoto Y, Noda Y, Lim KHC, Kawase T, Takahashi T, Inaba K, Kumano M, Yoshikawa N, Yoshioka Y, Nakamura K, Hiratsuka J, Itami J, Hayakawa K.
  • Journal Title: Brachytherapy Volume: 16 Issue: 3 Pages: 503-510
  • DOI: 10.1016/j.brachy.2017.01.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using interstitial brachytherapy: clinical results with a median follow-up of 26 months. (2016)
  • Author(s): Nose T, Otani Y, Asahi S, Tsukiyama I, Dokiya T, Saeki T, Fukuda I, Sekine H, Shikama N, Kumazaki Y, Takahashi T, Yoshida K, Kotsuma T, Masuda N, Yoden E, Nakashima K, Matsumura T
  • Journal Title: Breast Cancer Volume: 23 Pages: 861-868
  • Peer Reviewed
• [Journal Article] Salvage high-dose-rate brachytherapy for isolated vaginal recurrence of endometrial cancer. (2016)
  • Author(s): Baek S, Isohashi F, Yamaguchi H, Mabuchi S, Yoshida K, Kotsuma T, Yamazaki H, Tanaka E, Sumida I, Tamari K, Otani K, Seo Y, Suzuki O, Yoshioka Y, Kimura T, Ogawa K
  • Journal Title: Brachytherapy Volume: 15 Pages: 812-816
  • Peer Reviewed
• [Journal Article] Recommendations for high-risk clinical target volume definition with computed tomography for three-dimensional image-guided brachytherapy in cervical cancer patients (2016)
  • Author(s): Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Ii, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-ei Noda, Tomoko Kazumoto, Yoko Harima
  • Journal Title: J Radiat Res Volume: 56 Issue: 3 Pages: 1-10
  • DOI: 10.1093/jrr/rrw109
  • NAID: 120006959731
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simulation analysis of optimized brachytherapy for uterine cervical cancer: Can we select the best brachytherapy modality depending on tumor size? (2016)
  • Author(s): Yoshida K, Yamazaki H, Kotsuma T, Takenaka T, Ueda MM, Miyake S, Tsujimoto Y, Masui K, Yoshioka Y, Sumida I, Uesugi Y, Shimbo T, Yoshikawa N, Yoshioka H, Tanaka E, Narumi Y.
  • Journal Title: Brachytherapy Volume: 15 Issue: 1 Pages: 57-64
  • DOI: 10.1016/j.brachy.2015.10.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-Dose-Rate Brachytherapy as Monotherapy for Intermediate- and High-Risk Prostate Cancer: Clinical Results for a Median 8-Year Follow-Up. (2016)
  • Author(s): Yoshioka Y, Suzuki O, Isohashi F, Seo Y, Okubo H, Yamaguchi H, Oda M, Otani Y, Sumida I, Uemura M, Fujita K, Nagahara A, Ujike T, Kawashima A, Yoshida K, Yamazaki H, Nonomura N, Ogawa K.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 94 Issue: 4 Pages: 675-82
  • DOI: 10.1016/j.ijrobp.2015.05.044
  • Peer Reviewed
• [Journal Article] Treatment Results of Image-guided High-dose-rate Interstitial Brachytherapy for Pelvic Recurrence of Uterine Cancer (2015)
  • Author(s): Ken Yoshida, Hideya Yamazaki, Tadayuki Kotsuma, Koji Masui, Yasuo Yoshioka, Yasuo Uesugi, Taiju Shimbo, Nobuhiko Yoshikawa, Hiroto Yoshioka
  • Journal Title: Brachytherapy Volume: 印刷中 Issue: 4 Pages: 440-448
  • DOI: 10.1016/j.brachy.2015.02.195
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Definitive radiotherapy for primary vaginal cancer: correlation between treatment patterns and recurrence rate. (2015)
  • Author(s): Kanayama N, Isohashi F, Yoshioka Y, Baek S, Chatani M, Kotsuma T, Tanaka E, Yoshida K, Seo Y, Suzuki O, Mabuchi S, Shiki Y, Tatsumi K, Kimura T, Teshima T, Ogawa K.
  • Journal Title: J Radiat Res Volume: 56 Issue: 2 Pages: 346-353
  • DOI: 10.1093/jrr/rru115
  • Peer Reviewed / Open Access
• [Journal Article] Role of vaginal pallor reaction in predicting late vaginal stenosis after high-dose-rate brachytherapy in treatment-naive patients with cervical cancer. (2015)
  • Author(s): Yoshida K, Yamazaki H, Nakamura S, Masui K, Kotsuma T, Akiyama H, Tanaka E, Yoshikawa N, Uesugi Y, Shimbo T, Narumi Y, Yoshioka Y.
  • Journal Title: J Gynecol Oncol. Volume: 26 Issue: 3 Pages: 179-84
  • DOI: 10.3802/jgo.2015.26.3.179
  • Peer Reviewed / Open Access
• [Journal Article] Preliminary results of MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer. (2015)
  • Author(s): Ken Yoshida, Hideya Yamazaki, Tadashi Takenaka, Tadayuki Kotsuma, Shunsuke Miyake, Mari Ueda, Mineo Yoshida, Koji Masui, Yasuo Yoshioka, Yasuo Uesugi, Taiju Shimbo, Nobuhiko Yoshikawa, Hiroto Yoshioka, Kazumasa Aramoto, Yoshifumi Narumi
  • Journal Title: Brachytherapy Volume: 14 Pages: 1-8
  • Peer Reviewed
• [Journal Article] High-dose-rate interstitial brachytherapy in combination with androgen deprivation therapy for prostate cancer: are high-risk patients good candidates? (2014)
  • Author(s): Ken Yoshida, Hideya Yamazaki, Tadashi Takenaka, Tadayuki Kotsuma, Mineo Yoshida, Koji Masui, Yasuo Yoshioka, Yoshifumi Narumi, Toshitsugu Oka, Eiichi Tanaka
  • Journal Title: Strahlenther Onkol Volume: 190 Issue: 11 Pages: 1015-20
  • DOI: 10.1007/s00066-014-0675-4
  • Peer Reviewed
• [Journal Article] Role of novel risk classification method, Prostate Cancer Risk Index (PRIX) for clinically localized prostate cancer after high-dose-rate interstitial brachytherapy as monotherapy. (2014)
  • Author(s): Yoshida K, Yamazaki H, Nakamura S, Masui K, Kotsuma T, Akiyama H, Tanaka E, Yoshioka Y
  • Journal Title: Anticancer Res Volume: 34 Pages: 3077-81
  • Peer Reviewed
• [Journal Article] Comparison of common terminology criteria for adverse events v3.0 and radiation therapy oncology group toxicity score system after high-dose-rate interstitial brachytherapy as monotherapy for prostate cancer. (2014)
  • Author(s): Yoshida K, Yamazaki H, Nakamara S, Masui K, Kotsuma T, Akiyama H, Tanaka E, Yoshioka Y
  • Journal Title: Anticancer Res Volume: 34 Pages: 2015-8
  • Peer Reviewed
• [Journal Article] High-dose-rate interstitial brachytherapy in combination with androgen deprivation therapy for prostate cancer Are high-risk patients good candidates? (2014)
  • Author(s): KEN YOSHIDA, HIDEYA YAMAZAKI, TADASHI TAKENAKA, TADAYUKI KOTSUMA, MINEO YOSHIDA, KOJI MASUI, YASUO YOSHIOKA, YOSHIHUMI NARUMI, TOSHITSUGU OKA and EIICHI TANAKA
  • Journal Title: Stgahlentherapie und Onkology Volume: 未定
  • Peer Reviewed
• [Journal Article] Comparisons of Late Vaginal Mucosal Reactions Between Interstitial and Conventional Intracavitary Brachytherapy in Patients with Gynecological Cancer: Speculation on the Relation Between Pallor Reaction and Stenosis (2013)
  • Author(s): KEN YOSHIDA, HIDEYA YAMAZAKI, SATOAKI NAKAMURA, KOJI MASUI, TADAYUKI KOTSUMA, SUNG JAE BAEK, HIRONORI AKIYAMA, EIICHI TANAKA and YASUO YOSHIOKA
  • Journal Title: ANTICANCER RESEARCH Volume: 33 Pages: 3963-3968
  • Peer Reviewed
• [Journal Article] Re-irradiation Using Interstitial Brachytherapy Increases Vaginal Mucosal Reaction Compared to Initial Brachytherapy in Patients with Gynecological Cancer (2013)
  • Author(s): KEN YOSHIDA, HIDEYA YAMAZAKI, SATOAKI NAKAMURA, KOJI MASUI, TADAYUKI KOTSUMA, HIRONORI AKIYAMA, EIICHI TANAKA and YASUO YOSHIOKA
  • Journal Title: ANTICANCER RESEARCH Volume: 33 Pages: 5687-5692
  • Peer Reviewed
• [Presentation] 教育講演 腔内、ハイブリッド、組織内の棲み分け (2016)
  • Author(s): 吉田謙
  • Organizer: 第18回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: ホテルエルセラーン大阪（大阪府・大阪市）
  • Year and Date: 2016-05-27
• [Presentation] High-dose-rate image-guided interstitial brachytherapy for recurrent cervical adenocarcinoma. (2016)
  • Author(s): Yoshida K, Yamazaki H, Takenaka T, Kotsuma T, Masui K, Uesugi Y, Shimbo T, Yoshikawa N, Yoshioka H, Yoshioka Y, Tanaka E, Narumi Y
  • Organizer: The 35rd ESTRO, Turin, Italy, April, 2016
  • Place of Presentation: Tulin (Italy)
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] High-dose-rate image-guided interstitial brachytherapy as monotherapy for locally limited mobile tongue cancer. (2016)
  • Author(s): Yoshida K, Yamazaki H, Takenaka T, Kotsuma T, Masui K, Akiyama H, Uesugi Y, Shimbo T, Yoshikawa N, Yoshioka H, Tanaka E, Narumi Y
  • Organizer: The 35rd ESTRO, Turin, Italy, April, 2016
  • Place of Presentation: Tulin (Italy)
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] 3D-image based high-dose-rate interstitial brachytherapy as monotherapy for lower lip cancer: A preliminary study (2015)
  • Author(s): H. Akiyama, T. Kotsuma, K. Yoshida, K. Masui, H. Yamazaki, M. Mikami Ueda, T. Takenaka, T. Arika, E. Tanaka, S. Gamoh, K. Shimizutani
  • Organizer: 18th The European Cancer Congress
  • Place of Presentation: ウィーン
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] シンポジウム 子宮頸がんに対する3D-IGBT－治療法の標準化に向けて－ (2015)
  • Author(s): 吉田謙
  • Organizer: 第17回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 大宮
  • Year and Date: 2015-06-26
• [Presentation] MR画像誘導腔内照射における観察者間のTarget（GTV／ HR-CTV）delineation の差異の検討 (2015)
  • Author(s): 増井浩二、吉田謙、古妻理之、吉川信彦、山田幸美、高畑曉子、酒井晃二、山崎秀哉、山田恵
  • Organizer: 第17回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 大宮
  • Year and Date: 2015-06-26
• [Presentation] 舌癌高線量率組織内照射における舌浮腫による線量不足防止を目的としたデバイスの開発. (2015)
  • Author(s): 古妻理之、吉田謙、秋山広徳、増井浩二、武中正、上田麻里、辻本豊、久保勝一、山崎秀哉、有家巧、田中英一.
  • Organizer: 第17回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 大宮
  • Year and Date: 2015-06-26
• [Presentation] A preliminary treatment result of 3D CT-based high-dose-rate interstitial brachytherapy for lip cancer. (2015)
  • Author(s): Akiyama H, Kotsuma T, Yoshida K, Masui M, Yamazaki H, Tanaka E, Shimizutani K.
  • Organizer: 第39回日本頭頸部癌学会・第4回アジア頭頸部癌学会
  • Place of Presentation: 神戸
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] 低侵襲治療としての小線源治療 (2014)
  • Author(s): 吉田謙
  • Organizer: 第6回癌の低侵襲・集学的治療研究会
  • Place of Presentation: 千里阪急ホテル、豊中市、大阪府
  • Year and Date: 2014-11-15
• [Presentation] Role of Novel Risk Classification Method Prostate Cancer Risk Index (PRIX) for Clinically Localized Prostate Cancer after High-dose-rate Interstitial Brachytherapy as a Monotherapy. (2014)
  • Author(s): Yamazaki H, Yoshida K, Nakamura S, Narumi Y, Tanaka E, Yoshioka Y
  • Organizer: 15th Asian Oceanian Congress of Radiology
  • Place of Presentation: Kobe International Conference Center, Kobe, Hyogo
  • Year and Date: 2014-09-24 – 2014-09-28
• [Presentation] 子宮頸癌に対するImage-based intracavitary brachytherapy (2014)
  • Author(s): 古妻理之、田中英一、上田麻里、辻本豊、巽啓司、吉田謙、増井浩二、武中正
  • Organizer: 第307回日本医学放射線学会関西地方会
  • Place of Presentation: ホテルエルセラーン、大阪市北区
  • Year and Date: 2014-06-21
• [Presentation] 子宮頸癌IGBT (2014)
  • Author(s): 吉田 謙
  • Organizer: 第16回日本放射線腫瘍学会小線源治療部会
  • Place of Presentation: 幕張メッセ国際会議場、千葉市美浜区、千葉
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] High-dose-rate interstitial brachytherapy as monotherapy with hormone therapy for high-risk prostate cancer. (2014)
  • Author(s): Yoshida K, Yamazaki H, Takenaka T, Kotsuma T, Masui K, Uesugi Y, Shimbo T, Yoshioka H, Tanaka E, Narumi Y
  • Organizer: The 13rd ESTRO
  • Place of Presentation: Reed Messe Viena GmbH, Vienna, Austria
  • Year and Date: 2014-04-04 – 2014-04-08
• [Presentation] High-dose-rate interstitial brachytherapy (2014)
  • Author(s): KEN YOSHIDA, HIDEYA YAMAZAKI, TADASHI TAKENAKA, TADAYUKI KOTSUMA, KOJI MASUI, YASUO UESUGI, TAIJU SHIMBO, HIROTO YOSHIOKA, EIICHI TANAKA, YOSHIFUMI NARUMI
  • Organizer: ESTRO
  • Place of Presentation: ウィーン、オーストリア
• [Presentation] Treatment Results of Image-guided High-dose-rate Interstitial Brachytherapy for Recurrent Uterine Cancer (2013)
  • Author(s): YOSHIDA K, YAMAZAKI H, TAKENAKA T, KOTSUMA T, MASUI K, YOSHIOKA Y, UESUGI Y, SHIMBO T, TANAKA E, NARUMI Y
  • Organizer: ECCO
  • Place of Presentation: アムステルダム,オランダ
• [Presentation] ECCO参加報告 (2013)
  • Author(s): 吉田謙
  • Organizer: 第9回マイクロセレクトロンHDR研究会 、東京、2013年12月
  • Place of Presentation: 東京
• [Book] 放射線治療学 改訂5版 Ａ．直腸癌B．肛門癌D．腟癌 (2014)
  • Author(s): 吉田謙（井上俊彦、小川和彦）
  • Total Pages: 412
  • Publisher: 南山堂
• [Book] 小線源治療部会ガイドラインに基づく密封小線源治療 診療・物理QAマニュアル 編 6章 婦人科 E 組織内照射 8章 乳癌 (2013)
  • Author(s): 吉田謙（日本放射線腫瘍学会 小線源治療部会）
  • Total Pages: 288
  • Publisher: 金原出版
• [Book] チームで取り組む乳がん放射線療法 3章 乳がん放射線療法の実際、1. 乳房温存術後の放射線療法、4、加速乳房部分照射（APBI） (2013)
  • Author(s): 吉田謙 （佐々木 良平、淡河恵津世、唐津久美子）
  • Total Pages: 240
  • Publisher: （株）メディカル教育研究社