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Establishment of next generation cell therapy for diabetes on the prevascularization procedures with Adipose-Derived Stem Cell

Research Project

Project/Area Number 25461940
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

Inagaki Akiko  東北大学, 医学系研究科, 助教 (20360224)

Co-Investigator(Kenkyū-buntansha) 後藤 昌史  東北大学, 医学系研究科, 教授 (50400453)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords膵島移植 / 血管新生 / 移植・再生医療 / 移植・再生医学 / 脂肪由来幹細胞 / 糖尿病 / 皮下移植 / 膵島
Outline of Final Research Achievements

Subcutaneous islet transplantation is associated with minimal invasiveness, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcome. Therefore, in presence study, we evaluated the effectiveness of (Adipose-Derived Stem Cells: ADSC). Although the cure rates in the bFGF group were considerably higher than in the non-device and control group, but there was no significant difference among ADSC group and non-device group on the cure rate.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Presentation (4 results)

  • [Presentation] 血管誘導効果を有するRGD基含有コラーゲン素材の導入による皮下膵島移植の生着促進の試み2017

    • Author(s)
      植松智海、稲垣明子、中村保宏、猪村武弘、大内憲明、里見進、後藤昌史
    • Organizer
      第44回日本膵・膵島移植研究会
    • Place of Presentation
      京都市・京都大学医学部芝蘭会館
    • Year and Date
      2017-03-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵島皮下移植モデルにおけるCTを用いた移植前血管床評価の試み2016

    • Author(s)
      植松智海、稲垣明子、猪村 梢、五十嵐康宏、大内憲明、里見 進、後藤昌史
    • Organizer
      第43回膵・膵島移植研究会
    • Place of Presentation
      ホテルグランヴィア広島(広島県広島市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 塩基性線維芽細胞増殖因子デバイスによる皮下血管床構築のための霊長類における検証2016

    • Author(s)
      稲垣明子、猪村 梢、柏山 浩、猪村武弘、五十嵐康宏、末田輝子、笠井憲雪、小野文子、後藤昌史
    • Organizer
      第43回膵・膵島移植研究会
    • Place of Presentation
      ホテルグランヴィア広島(広島県広島市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 移植前血管床構築のためのbFGF新生血管誘導効果の霊長類と小動物モデルにおける比較検証2015

    • Author(s)
      稲垣明子、五十嵐康宏、猪村 梢、柏山 浩、猪村武弘、末田輝子、笠井憲雪、小野文子、後藤昌史
    • Organizer
      第42回日本膵・膵島移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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