| Project/Area Number |
25461947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Takahashi Hideo 近畿大学, 医学部, 教授 (60335627)
貞森 裕 岡山大学, 医歯(薬)学総合研究科, 准教授 (30362974)
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| Co-Investigator(Renkei-kenkyūsha) |
Sadamori Hiroshi 岡山大学, 医歯薬学総合研究科, 准教授 (30362974)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | DAMPｓ / 肝障害 / HMGB1 / 外科侵襲 / 臓器障害 / HMGB-１ / 肝再生 / DAMP / HMGB-1 / 肝切除 |
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| Outline of Final Research Achievements |
Organ failure after surgery sometimes becomes a cause of death. We think hyper immunological response is one of this causes. I analyzed this immunoresponse system and studied for prognostic improvement of organ failure via immunological control.
I paid attention to HMGB1 in DAMPs which was a causative agent of the immunoresponse by the surgery. It was thought that HMGB1 participated in angiogenetic control via macrophage. The anti-HMGB1 mAb significantly ameliorated the degree of ischemia/reperfusion injury of the liver. We think this depends on hepatocellular proliferation.
HMGB1 control may enable improvement of ischemia/reperfusion injury of the liver.
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