New regulation system for liver injury after surgery via immunological reaction against DAMPs
| Project/Area Number |
25461947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Takahashi Hideo 近畿大学, 医学部, 教授 (60335627)
貞森 裕 岡山大学, 医歯(薬)学総合研究科, 准教授 (30362974)
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| Co-Investigator(Renkei-kenkyūsha) |
Sadamori Hiroshi 岡山大学, 医歯薬学総合研究科, 准教授 (30362974)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | DAMPｓ / 肝障害 / HMGB1 / 外科侵襲 / 臓器障害 / HMGB-１ / 肝再生 / DAMP / HMGB-1 / 肝切除 |
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| Outline of Final Research Achievements |
Organ failure after surgery sometimes becomes a cause of death. We think hyper immunological response is one of this causes. I analyzed this immunoresponse system and studied for prognostic improvement of organ failure via immunological control.
I paid attention to HMGB1 in DAMPs which was a causative agent of the immunoresponse by the surgery. It was thought that HMGB1 participated in angiogenetic control via macrophage. The anti-HMGB1 mAb significantly ameliorated the degree of ischemia/reperfusion injury of the liver. We think this depends on hepatocellular proliferation.
HMGB1 control may enable improvement of ischemia/reperfusion injury of the liver.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Anti-high mobility group box 1 monoclonal antibody improves ischemia/reperfusion injury and mode of liver regerenation after partial hepatectomy2016
Author(s)
Sugihara M, Sadamori H, Nishibori M, Sato Y, Tazawa H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Ohno K, Nagasaka T, Yoshino T, Takahashi HK, Yagi T, Fujiwara T
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Journal Title
American Journal of Surgery
Volume: Jan;211(1)
Pages: 179-188
Related Report
Peer Reviewed / Open Access
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[Journal Article] Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction2014
Author(s)
Okuma Y, Liu K, Wake H, Liu R, Nishimura Y, Hui Z, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I,Takahashi H, K, Mori S, Nishibori M.
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Journal Title
Neuropharmacology
Volume: Oct;85
Pages: 18-26
Related Report
Peer Reviewed / Open Access
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