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Novel therapeutic development with the target of cancer cell eradication against cancer stem cells

Research Project

Project/Area Number 25461953
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

Eguchi Hidetoshi  九州大学, 大学病院, 講師 (90527756)

Co-Investigator(Kenkyū-buntansha) Iguchi Tomohiro  九州大学, 大学病院, 助教 (30598959)
主藤 朝也  久留米大学, 医学部, 助教 (50309803)
Co-Investigator(Renkei-kenkyūsha) Mimori Koshi  九州大学, 大学病院, 教授 (50322748)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords癌幹細胞 / 癌免疫治療 / 樹状細胞療法 / 癌抗原 / PD-1 / HLA class I / PLS3 / neoantigen / Plastin3 / EMT / 癌幹細胞化 / 癌特異抗原
Outline of Final Research Achievements

We identified a Plastin3 (PLS3) that was only detectable in the metastasis by comprehensive genetic analysis using a sample of colon cancer cases. It was confirmed that cancer cells introduced PLS3 were promoting the epithelial-mesenchymal transition (EMT) and the cancer stem cells.
Cancer cell-killing effect of cytotoxic T cell was reduced. Because the binding of PD-L1 on cancer cell to PD-1 on lymphocyte transmits an inhibitory signal which reduces the proliferation of cytotoxic T cells. High expression of both HLA class I and PD-L1 had a high recurrence rate and poor prognosis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (9 results)

  • [Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.2016

    • Author(s)
      R. Uchi (他40名, 山本36番目)
    • Journal Title

      PLoS Genetics

      Volume: 12 Issue: 2 Pages: 1-24

    • DOI

      10.1371/journal.pgen.1005778

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical and biological significance of circulating tumor cells in cancer.2016

    • Author(s)
      Masuda T, Hayashi N, Iguchi T, Ito S, Eguchi H, Mimori K.
    • Journal Title

      Mol Oncol.

      Volume: 10 Issue: 3 Pages: 408-17

    • DOI

      10.1016/j.molonc.2016.01.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.2016

    • Author(s)
      G. Sawada (他43名, 山本21番目)
    • Journal Title

      Gastroenterology

      Volume: 150 Issue: 5 Pages: 1171-1182

    • DOI

      10.1053/j.gastro.2016.01.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma2015

    • Author(s)
      Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Yamasaki M, Tanaka F, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Tanaka Y, Calin G, Miyano S, Doki Y, Mori M, Mimori K
    • Journal Title

      PLoS One

      Volume: 10(10) Issue: 10 Pages: e0139808-e0139808

    • DOI

      10.1371/journal.pone.0139808

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer.2015

    • Author(s)
      Iguchi T, Uchi R, Nambara S, Saito T, Komatsu H, Hirata H, Ueda M, Sakimura S, Takano Y, Kurashige J, Shinden Y, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1385-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.2015

    • Author(s)
      Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K.
    • Journal Title

      Ann Surg Oncol.

      Volume: epub Issue: S3 Pages: 1436-1443

    • DOI

      10.1245/s10434-015-4418-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of GAB2, a scaffolding/docking protein acting downstream of EGFR in human colorectal cancer.2014

    • Author(s)
      Matsumura T, Sugimachi K, Takahashi Y, Uchi R, Sawada G, Ueda M, Hirata H, Sakimura S, Ueo H, Takano Y, Kurashige J, Shinden Y, Eguchi H, Sudo T, Yamamoto H, Doki Y, Mori M, Mimori K.
    • Journal Title

      Ann Surg Oncol.

      Volume: 4 Issue: S4 Pages: 743-749

    • DOI

      10.1245/s10434-014-3889-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma.2014

    • Author(s)
      Hirata H, Sugimachi K, Takahashi Y, Ueda M, Sakimura S, Uchi R, Kurashige J, Takano Y, Nanbara S, Komatsu H, Saito T, Shinden Y, Iguchi T, Eguchi H, Atsumi K, Sakamoto K, Doi T, Hirakawa M, Honda H, Mimori K.
    • Journal Title

      Ann Surg Oncol.

      Volume: epub Issue: S3 Pages: 1402-9

    • DOI

      10.1245/s10434-014-4242-0

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic significance of high mobility group box 1 (HMGB1) expression in patients with colorectal cancer.2014

    • Author(s)
      Ueda M, Takahashi Y, Shinden Y, Sakimura S, Hirata H, Uchi R, Takano Y, Kurashige J, Iguchi T, Eguchi H, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 5357-62

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis2013

    • Author(s)
      Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M.
    • Journal Title

      Cancer Res

      Volume: 73 Issue: 7 Pages: 2059

    • DOI

      10.1158/0008-5472.can-12-0326

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 食道扁平上皮癌におけるZNF750発現の意義について2015

    • Author(s)
      南原翔、澤田元太、新井田厚司、内龍太郎、新田吉陽、井口友宏、江口英利、伊藤修平、増田隆明、杉町圭史、前原喜彦、三森功士
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] The role of Plastin3 on the acquisition of cancer stemness and liver metastasis in colorectal camcer2014

    • Author(s)
      杉町圭史、横堀武彦、井口友宏、江口英利、前原喜彦、三森功士
    • Organizer
      第25回日本消化器癌発生学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-11 – 2014-11-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Gene Set Enrichment Analysis による食道癌における上皮間葉転換の発現プロファイリング2014

    • Author(s)
      井口友宏、主藤朝也、平田秀成、崎村正太郎、上田正射、高野裕樹、内龍太郎、藏重淳二、新田吉陽、江口英利、杉町圭史、三森功士
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌原発巣においてSNAI2発現を抑制し、EMTを制御するmicroRNAの同定2014

    • Author(s)
      江口英利、高野裕樹、松村多恵、藏重淳二、主藤朝也、杉町圭史、猪股雅史、北野正剛、三森功士
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌症例の宿主骨髄細胞において腹膜播種と関連する遺伝子夫microRNAaxisの同定2014

    • Author(s)
      江口英利、岩谷岳司、内龍太郎、高野裕樹、松村多恵、藏重淳二、新田吉陽、主藤朝也、杉町圭史、三森功士
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌原発巣におけるmiR506発現の臨床的意義について2014

    • Author(s)
      江口英利、崎村正太郎、上田正射、平田秀成、上尾裕紀、内龍太郎、高野裕樹、松村多恵、藏重淳二、澤田元太、高橋佑典、新田吉陽、主藤朝也、杉町圭史、猪股雅史、北野正剛、三森功士
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 外科領域におけるゲノム研究の進歩 大腸発癌関連遺伝子多型8q24からみた新しい発癌機構について2013

    • Author(s)
      三森 功士, 松村 多恵, 上尾 裕紀, 高野 裕樹, 内 龍太郎, 美馬 浩介, 藏重 淳二, 福永 光子, 石橋 正久, 澤田 元太, 高橋 佑典, 甲斐 裕一郎, 秋吉 清百合, 江口 英利, 主藤 朝也, 杉町 圭史
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 分子生物学的手法を用いた肝細胞癌治療戦略 肝細胞癌術後再発を予測する新たなバイオマーカーとなる血清中マイクロRNAの解析2013

    • Author(s)
      杉町 圭史, 松村 多恵, 石橋 正久, 上尾 裕紀, 高野 裕樹, 美馬 浩介, 藏重 淳二, 高橋 佑典, 澤田 元太, 秋吉 清百合, 江口 英利, 主藤 朝也, 調 憲, 落谷 孝広, 前原 喜彦, 三森 功士
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌と糖尿病との交互作用に関する包括的遺伝子解析2013

    • Author(s)
      江口英利、主藤朝也、藏重淳二、石橋正久、澤田元太、高橋 佑典、杉町圭史、北野正剛、三森功士
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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