Novel therapeutic development with the target of cancer cell eradication against cancer stem cells
Project/Area Number |
25461953
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
Iguchi Tomohiro 九州大学, 大学病院, 助教 (30598959)
主藤 朝也 久留米大学, 医学部, 助教 (50309803)
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Co-Investigator(Renkei-kenkyūsha) |
Mimori Koshi 九州大学, 大学病院, 教授 (50322748)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 癌幹細胞 / 癌免疫治療 / 樹状細胞療法 / 癌抗原 / PD-1 / HLA class I / PLS3 / neoantigen / Plastin3 / EMT / 癌幹細胞化 / 癌特異抗原 |
Outline of Final Research Achievements |
We identified a Plastin3 (PLS3) that was only detectable in the metastasis by comprehensive genetic analysis using a sample of colon cancer cases. It was confirmed that cancer cells introduced PLS3 were promoting the epithelial-mesenchymal transition (EMT) and the cancer stem cells. Cancer cell-killing effect of cytotoxic T cell was reduced. Because the binding of PD-L1 on cancer cell to PD-1 on lymphocyte transmits an inhibitory signal which reduces the proliferation of cytotoxic T cells. High expression of both HLA class I and PD-L1 had a high recurrence rate and poor prognosis.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma2015
Author(s)
Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Yamasaki M, Tanaka F, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Tanaka Y, Calin G, Miyano S, Doki Y, Mori M, Mimori K
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Journal Title
PLoS One
Volume: 10(10)
Issue: 10
Pages: e0139808-e0139808
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer.2015
Author(s)
Iguchi T, Uchi R, Nambara S, Saito T, Komatsu H, Hirata H, Ueda M, Sakimura S, Takano Y, Kurashige J, Shinden Y, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
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Journal Title
Anticancer Res.
Volume: 35
Pages: 1385-8
Related Report
Peer Reviewed / Open Access
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[Journal Article] The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.2015
Author(s)
Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K.
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Journal Title
Ann Surg Oncol.
Volume: epub
Issue: S3
Pages: 1436-1443
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical significance of GAB2, a scaffolding/docking protein acting downstream of EGFR in human colorectal cancer.2014
Author(s)
Matsumura T, Sugimachi K, Takahashi Y, Uchi R, Sawada G, Ueda M, Hirata H, Sakimura S, Ueo H, Takano Y, Kurashige J, Shinden Y, Eguchi H, Sudo T, Yamamoto H, Doki Y, Mori M, Mimori K.
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Journal Title
Ann Surg Oncol.
Volume: 4
Issue: S4
Pages: 743-749
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma.2014
Author(s)
Hirata H, Sugimachi K, Takahashi Y, Ueda M, Sakimura S, Uchi R, Kurashige J, Takano Y, Nanbara S, Komatsu H, Saito T, Shinden Y, Iguchi T, Eguchi H, Atsumi K, Sakamoto K, Doi T, Hirakawa M, Honda H, Mimori K.
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Journal Title
Ann Surg Oncol.
Volume: epub
Issue: S3
Pages: 1402-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic significance of high mobility group box 1 (HMGB1) expression in patients with colorectal cancer.2014
Author(s)
Ueda M, Takahashi Y, Shinden Y, Sakimura S, Hirata H, Uchi R, Takano Y, Kurashige J, Iguchi T, Eguchi H, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K
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Journal Title
Anticancer Res.
Volume: 34
Pages: 5357-62
Related Report
Peer Reviewed
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[Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis.2013
Author(s)
Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M.
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Journal Title
Cancer Res
Volume: 1; 73(7)
Issue: 7
Pages: 2059-69
DOI
Related Report
Peer Reviewed
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[Presentation] 外科領域におけるゲノム研究の進歩 大腸発癌関連遺伝子多型8q24からみた新しい発癌機構について2013
Author(s)
三森 功士, 松村 多恵, 上尾 裕紀, 高野 裕樹, 内 龍太郎, 美馬 浩介, 藏重 淳二, 福永 光子, 石橋 正久, 澤田 元太, 高橋 佑典, 甲斐 裕一郎, 秋吉 清百合, 江口 英利, 主藤 朝也, 杉町 圭史
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡市
Related Report
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[Presentation] 分子生物学的手法を用いた肝細胞癌治療戦略 肝細胞癌術後再発を予測する新たなバイオマーカーとなる血清中マイクロRNAの解析2013
Author(s)
杉町 圭史, 松村 多恵, 石橋 正久, 上尾 裕紀, 高野 裕樹, 美馬 浩介, 藏重 淳二, 高橋 佑典, 澤田 元太, 秋吉 清百合, 江口 英利, 主藤 朝也, 調 憲, 落谷 孝広, 前原 喜彦, 三森 功士
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡市
Related Report
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