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Analysis of mechanisms of function of EpCAM toward the development of molecular target for anaplastic thyroid cancer

Research Project

Project/Area Number 25461976
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionShinshu University

Principal Investigator

ITO Ken-ichi  信州大学, 学術研究院医学系, 教授 (10334905)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords甲状腺癌 / 甲状腺未分化癌 / 新規治療標的の開発 / 希少癌のバイオロジー / 分子標的の探索 / 稀少癌のバイオロジー / 上皮間葉転換 / 甲状腺癌未分化癌 / 癌のバイオロジー
Outline of Final Research Achievements

Anaplastic thyroid cancer is considered to be one of the most aggressive human malignancies, and the mean survival time after diagnosis is approximately six months, regardless of treatments. To detect the molecules involved in the aggressive phenotype of anaplastic thyroid carcinoma, we performed in vitro analysis using several thyroid cancer cell lines.
In our study, the anaplastic thyroid cancer cell lines demonstrated higher levels of expression of EpCAM, CD44 variant isoforms (3 and 6), caudin-7 as well as a higher ALDH1 activity than the differentiated thyroid cancer cell lines. Furthermore, co-expression of EpCAM and ALDH1 was observed in anaplastic cancer cells. Our study suggests the possibility that EpCAM, together with CD44 variant isoforms and claudin-7 as well as ALDH1, may be involved in the development of the aggressive phenotype of anaplastic thyroid carcinoma. Our findings may suggest a novel therapeutic strategy for treatment of anaplastic thyroid carcinoma.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results)

  • [Journal Article] Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review2016

    • Author(s)
      Oba T, Ono M, Iesato A, Hanamura T, Watanabe T, Ito T, Kanai T, Maeno K, Ito K, Tateishi A, Yoshizawa A, Takayama F
    • Journal Title

      Onco Targets Ther

      Volume: 9 Pages: 1641-1646

    • DOI

      10.2147/ott.s88726

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coexpression of EpCAM, CD44 variant isoforms and Claudin-7 in anaplastic thyroid carcinoma2014

    • Author(s)
      Okada T, Nakamura T, Watanabe T, Onoda N, Asida A, Okuyama R, Ito K
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: 1-13

    • DOI

      10.1371/journal.pone.0094487

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 甲状腺癌の発癌、進展における 転写調節因子PATZ1発現の意義2016

    • Author(s)
      家里 明日美,小野真由,大場崇旦,福島優子 伊藤勅子,金井敏晴,前野一真,伊藤研一
    • Organizer
      第28回日本内分泌外科学会総会
    • Place of Presentation
      ロイヤルホール横浜(横浜市中区)
    • Year and Date
      2016-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 甲状腺癌の発癌と進展における転写調節因子PATZ1発現の関与2015

    • Author(s)
      家里明日美,小野真由,大場崇旦,福島優子,伊藤勅子, 金井敏晴,前野一真,伊藤研一
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 甲状腺癌における転写因子PATZ1発現の意義2015

    • Author(s)
      家里明日美,小野真由,大場崇旦,花村徹,伊藤勅子,金井敏晴,前野一真,伊藤研一
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 甲状腺未分化癌の分子標的開発に向けたEpCAMの機能解析2014

    • Author(s)
      中村輝郎,上条しのぶ,伊藤研一
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 甲状腺未分化癌におけるEpCAMとその関連因子CD44,claudin-7の発現とALDH1酵素活性2014

    • Author(s)
      岡田敏宏,大場崇旦,家里明日美,花村徹,渡邉隆之,伊藤勅子,金井敏晴,前野一真,伊藤研一,小野田尚佳
    • Organizer
      第26回日本内分泌外科学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Research-status Report
  • [Presentation] Association of CD44 expression and ALDH1 activity in thyroid cancer.2013

    • Author(s)
      Toshihiro Okada, Ken-ichi Ito, Jun Amano, Naoyoshi Onoda
    • Organizer
      AACR Annual meeting 2013
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 甲状腺癌におけるCD44の発現とALDH1酵素活性2013

    • Author(s)
      岡田敏宏,家里明日美,花村徹,村松沙織,村山幸一,渡邉隆之,金井敏晴,前野一真,望月靖弘, 伊藤研一,天野純,小野田尚佳
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 甲状腺未分化癌におけるCD44, EpCAMの発現2013

    • Author(s)
      岡田敏宏,伊藤研一,天野純,小野田尚佳
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      松本市
    • Related Report
      2013 Research-status Report
  • [Presentation] 甲状腺未分化癌におけるCD44,EpCAMの発現とALDH1酵素活性2013

    • Author(s)
      ② 岡田敏宏,大場崇旦,家里明日美,花村徹,渡邉隆之,金井敏晴,前野一真,伊藤研一,天野純, 小野田尚佳
    • Organizer
      第46回日本甲状腺外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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