Elucidation of Mechanism for a pathological finding "Tumor budding" in esophageal cancer and identification of new prognostic factors

• Project/Area Number: 25461977
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: KOIKE Masahiko 名古屋大学, 医学(系)研究科(研究院), 講師 (10378094)
• Co-Investigator(Kenkyū-buntansha): YAMADA Suguru 名古屋大学, 医学部附属病院, 病院講師 (30467287) ; FUJII Tsutomu 名古屋大学, 医学系研究科, 准教授 (60566967) ; KODERA Yasuhiro 名古屋大学, 医学系研究科, 教授 (10345879)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: budding / 食道癌 / L1 / EMT / 予後因子 / EM

Outline of Final Research Achievements

Pathological finding "Tumor budding" in esophageal cancer has significant correlation to the prognosis of the patients under went esophagectomy. WE focused on EMT (Epithelial to mesenchymal transition). The EMT status and expression of related protein significantly correlate to the status of tumor budding. These findings suggested EMT could have a role in the genesis of Tumor budding.
On the other hand, expression of L1CAM using rt-PCR and Western blotting was investigated in the same specimens. However, there was no significant relation between expression of L1CAM and the prognosis of the patients. Unlike in gastric cancer, L1CAM is not a useful prognostic factor for esophageal cancer.