Involvement of EMT in anaplastic thyroid carcinoma
Project/Area Number |
25461992
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Osaka City University |
Principal Investigator |
Onoda Naoyoshi 大阪市立大学, 大学院医学研究科, 准教授 (30295703)
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Co-Investigator(Kenkyū-buntansha) |
野田 諭 大阪市立大学, 大学院医学研究科, 講師 (20382103)
柏木 伸一郎 大阪市立大学, 大学院医学研究科, 講師 (80637017)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 甲状腺癌 / 未分化癌 / 培養細胞株 / 上皮間葉転換 / 甲状腺未分化癌 / nestin / E-cadherin |
Outline of Final Research Achievements |
Both OCUT-1C and OCUT-1F was the human anaplastic thyroid cancer cell lines derived from a single original tumor, and demonstrated same DNA profile. OCUT-1C showed epithelial phenotype with E-cadherin expression, whereas OCUT-1F displayed mesenchymal phenotype by losing E-cadherin expression for unknown reason. E-cadherin expression was inhibited in OCUT-1C by the exposure to TGF-beta. Still, no morphological change was recognized at the same time. Markers indicating the mesenchymal phenotype were commonly found in the clinical samples of anaplastic thyroid cancer. Nestin, one of these markers, expression was suggested to be a poor prognostic indicator, independent of the clinical features of the patients
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Report
(5 results)
Research Products
(63 results)
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[Journal Article] The Safety and Efficacy of Weekly Paclitaxel Administration for Anaplastic Thyroid Cancer Patients: A Nationwide Prospective Study.2016
Author(s)
Onoda N, Sugino K, Higashiyama T, Kammori M, Toda K, Ito K, Yoshida A, Suganuma N, Nakashima N, Suzuki S, Tsukahara K, Noguchi H, Koizumi M, Nemoto T, Hara H, Miyauchi A, Sugitani I.
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Journal Title
Thyroid.
Volume: 26
Issue: 9
Pages: 1293-1299
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Histopathological analysis of anaplastic thyroid carcinoma cases with long-term survival: A report from the Anaplastic Thyroid Carcinoma Research Consortium of Japan2016
Author(s)
Hirokawa M, Sugitani I, Kakudo K, Sakamoto A, Higashiyama T, Sugino K, Toda K, Ogasawara S, Yoshimoto S, Hasegawa Y, Imai T, Onoda N, Orita Y, Kammori M, Fujimori K, Yamada H.
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Journal Title
Endocrine Journal
Volume: 63
Issue: 5
Pages: 441-447
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
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[Journal Article] Nonfunctional adrenocortical carcinoma initially presenting as retroperitoneal haemorrhage.2015
Author(s)
Kashiwagi S, Amano R, Onoda N, Noda S, Hirata K, Asano Y, Kurata K, Miura K, Yamazoe S, Kimura K, Ohsawa M, Kitagawa S, Hirakawa K.
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Journal Title
BMC Surgery
Volume: 15
Issue: 1
Pages: 46-46
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A case of bilateral pheochromocytoma during pregnancy.2015
Author(s)
Kitayama K, Kashiwagi S, Amano R, Noda S, Ohira G, Yamazoe S, Kimura K,Hamamoto K, Hamuro A, Ohsawa M, Onoda N, Hirakawa K.
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Journal Title
BMC Surg.
Volume: 15
Issue: 1
Pages: 55-55
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Concept and design of a nationwide prospective feasibility/efficacy/safety study of weekly paclitaxel for patients with pathologically confirmed anaplastic thyroid cancer (ATCCJ-PTX-P2).2015
Author(s)
Onoda N, Sugitani I, Higashiyama T, Hara H, Ito K, Kammori M, Sugino K, Suzuki S, Toda K, Yoshida A, Miyauchi A.
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Journal Title
BMC Cancer
Volume: 15
Issue: 1
Pages: 475-475
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Anaplastic Thyroid Carcinoma Accompanied by Uncontrollable Eosinophilia2015
Author(s)
Shiraishi J, Koyama H, Seki M, Hatayama M, Naka M, Kurajoh M, Okazaki H, Shoji T, Moriwaki Y, Yamamoto T, Tsuchida Y, Tsukamoto Y, Hirota S, Onoda N, Namba M.
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Journal Title
Internal Medicine
Volume: 54
Issue: 6
Pages: 611-616
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Amplification of the human epidermal growth factor receptor 2 gene in differentiated thyroid cancer correlates with telomere shortening.2013
Author(s)
Sugishita Y, Kammori M, Yamada O, Poon SS, Kobayashi M, Onoda N, Yamazaki K, Fukumori T, Yoshikawa K, Onose H, Ishii S, Yamada E, Yamada T.
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Journal Title
Int J Oncol
Volume: 42
Issue: 5
Pages: 1589-1596
DOI
Related Report
Peer Reviewed
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[Journal Article] Strategy of operative treatment of hyperparathyroidism using US scan and (99m)Tc-MIBI SPECT/CT.2013
Author(s)
Noda S, Onoda N, Kashiwagi S, Kawajiri H, Takashima T, Ishikawa T, Yoshida A, Higashiyama S, Kawabe J, Imanishi Y, Tahara H, Inaba M, Osawa M, Hirakawa K.
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Journal Title
Endocr J
Volume: 61
Pages: 225-230
NAID
Related Report
Peer Reviewed
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[Presentation] 食道憩室を合併した甲状腺癌の1例2016
Author(s)
飯盛 望, 小野田 尚佳, 瀬良 知央, 田内 幸枝, 徳本 真央, 柏木 伸一郎, 野田 諭, 高島 勉, 大澤 政彦, 平川 弘聖, 大平 雅一
Organizer
第49回 日本甲状腺外科学会学術集会
Place of Presentation
甲府富士屋ホテル(山梨県甲府市)
Year and Date
2016-10-26
Related Report
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[Presentation] 前胸部に皮膚瘻を形成した甲状腺乳頭癌の1切除例2016
Author(s)
野田 諭, 小野田 尚佳, 浅野 有香, 田内 幸枝, 徳本 真央, 柏木 伸一郎, 高島 勉, 平川 弘聖, 大平 雅一
Organizer
第49回 日本甲状腺外科学会学術集会
Place of Presentation
甲府富士屋ホテル(山梨県甲府市)
Year and Date
2016-10-26
Related Report
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[Presentation] 血友病を合併したBasedow病の1手術例2016
Author(s)
瀬良 知央, 小野田 尚佳, 飯盛 望, 後藤 航, 田内 幸枝, 徳本 真央, 柏木 伸一郎, 野田 諭, 高島 勉, 武岡 康信, 中根 孝彦, 平川 弘聖, 大平 雅一
Organizer
第49回 日本甲状腺外科学会学術集会
Place of Presentation
甲府富士屋ホテル(山梨県甲府市)
Year and Date
2016-10-26
Related Report
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[Presentation] 甲状腺全摘後の治療成績から見た進行甲状腺乳頭癌に対する治療戦略2016
Author(s)
小野田 尚佳, 野田 諭, 柏木 伸一郎, 倉田 研人, 浅野 有香, 石川 哲郎, 徳本 真央, 森崎 珠実, 川尻 成美, 高島 勉, 平川 弘聖
Organizer
第116回 日本外科学会総会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2016-04-14
Related Report
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[Presentation] Nestin is an independent molecular prognostic factor in patients with anaplastic thyroid carcinoma.2014
Author(s)
Kurata K, Onoda N, Noda S, Kashiwagi S, Asano Y, Kawajiri H, Takashima T, Tanaka S, Ohsawa M, Hirakawa K
Organizer
American Association for Cancer Research Annual Meeting 2014
Place of Presentation
SanDiego Convention Center (SanDiego, CA)
Year and Date
2014-04-05 – 2014-04-09
Related Report
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