| Project/Area Number |
25462041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGURE Aiichiro 産業医科大学, 医学部, 非常勤医師 (20289581)
山口 幸二 産業医科大学, 医学部, 特任教授 (50191226)
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| Co-Investigator(Renkei-kenkyūsha) |
MATAYOSHI Nobutaka 産業医科大学, 医学部, 非常勤医師 (00721630)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | IP3 レセプター / カルシウムシグナリング / 細胞増殖 / 胃癌 / イノシトール３リン酸 / アポトーシス / 予後 / InsP3R |
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| Outline of Final Research Achievements |
The inositol 1,4,5-trisphosphate receptor (InsP3R) mediates Ca2+ signaling in epithelia and regulates cellular functions. Expression of all three InsP3R isoforms was evaluated in tissue from gastric mucosal and carcinomas surgically resected from 77 patients. Type 1 InsP3R was not seen in both normal gastric mucosa and gastric cancer. Dense apical localization of type 2 InsP3R was seen in gastric funds gland.Various level of type 2 InsP3R was observed in cancer cells. Dense apical localization of type 3 InsP3 receptor was seen in gastric pits. Various level of type 3 InsP3R was seen in gastric cancer. No correlation between type 3 InsP3 receptor expression and prognosis was observed in gastric cancer patients. Meanwhile, heavier expression of type 2 InsP3R also was associated with decreased 5-year survival. Type 2 InsP3R expression is a a novel and useful indicator of prognosis in patients with gastric cancer.
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