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Expression of Inositol 1,4,5-trisphosphate receptors (InsP3Rs) in gastric cancer patients

Research Project

Project/Area Number 25462041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SHIBAO Kazunori  産業医科大学, 医学部, 講師 (10330987)

Co-Investigator(Kenkyū-buntansha) HIGURE Aiichiro  産業医科大学, 医学部, 非常勤医師 (20289581)
山口 幸二  産業医科大学, 医学部, 特任教授 (50191226)
Co-Investigator(Renkei-kenkyūsha) MATAYOSHI Nobutaka  産業医科大学, 医学部, 非常勤医師 (00721630)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsIP3 レセプター / カルシウムシグナリング / 細胞増殖 / 胃癌 / イノシトール3リン酸 / アポトーシス / 予後 / InsP3R
Outline of Final Research Achievements

The inositol 1,4,5-trisphosphate receptor (InsP3R) mediates Ca2+ signaling in epithelia and regulates cellular functions. Expression of all three InsP3R isoforms was evaluated in tissue from gastric mucosal and carcinomas surgically resected from 77 patients. Type 1 InsP3R was not seen in both normal gastric mucosa and gastric cancer. Dense apical localization of type 2 InsP3R was seen in gastric funds gland.Various level of type 2 InsP3R was observed in cancer cells. Dense apical localization of type 3 InsP3 receptor was seen in gastric pits. Various level of type 3 InsP3R was seen in gastric cancer. No correlation between type 3 InsP3 receptor expression and prognosis was observed in gastric cancer patients. Meanwhile, heavier expression of type 2 InsP3R also was associated with decreased 5-year survival. Type 2 InsP3R expression is a a novel and useful indicator of prognosis in patients with gastric cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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