Development of prognostic prediction system based on novel pathological prognostic indicators and Nomogram in colorectal cancer

• Project/Area Number: 25462075
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: National Defense Medical College
• Principal Investigator: Ueno Hideki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 教授 (90597535)
• Co-Investigator(Kenkyū-buntansha): 石原 聡一郎 東京大学, 医学部附属病院, 講師 (00376443) ; 石黒 めぐみ 東京医科歯科大学, 大学院医歯学総合研究科, ジョイントリサーチ講座准教授 (10456238) ; 長谷 和生 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 教授 (50511268) ; 中村 好宏 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 進学課程, 准教授 (60415255) ; 金光 幸秀 国立研究開発法人国立がん研究センター, 中央病院, 科長 (60522977)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 大腸癌 / 予後 / Nomogram / 簇出 / 低分化胞巣 / 線維性癌間質 / 非連続性癌進展 / 神経浸潤 / 外科病理学 / 予後解析

Outline of Final Research Achievements

The purpose of this study was to develop a novel prognostic prediction system in colorectal cancer (CRC) through identifying new pathological prognostic factors. We identified 5 new pathological factors with original assessment criteria, which had prognostic power superior to other conventional factors. In a multicenter database of CRC patients, we developed a prognostic prediction model (Nomogram) with favorable prognostic prediction power. It is determined that our results will be validated in a domestic multicenter clinical study and are now being fully utilized to develop study design of another clinical trial. Furthermore, a series of our results have been paid attention from the West and it has been determined to launch an international study for new pathological factors involving 8 countries. We believe our study products are expected to further contribute to the establishment of personalized CRC treatment through such domestic and international initiatives.

Research Products

• [Int'l Joint Research] Radboud University Medical Center(オランダ)
• [Int'l Joint Research] Leeds University(英国)
• [Int'l Joint Research] Mount Sinai Hospital(カナダ)
• [Int'l Joint Research] Bern University(スイス)
• [Int'l Joint Research] Bayreuth University(ドイツ)
• [Int'l Joint Research]
• [Journal Article] Histologic categorization of desmoplastic reaction: its relevance to the colorectal cancer microenvironment and prognosis. (2015)
  • Author(s): Hideki Ueno, et al
  • Journal Title: Ann Surg Oncol Volume: 22 Issue: 6 Pages: 1504-1512
  • DOI: 10.1007/s00428-015-1756-1
  • Peer Reviewed
• [Journal Article] Prognostic value of poorly differentiated clusters in the primary tumor in patients undergoing hepatectomy for colorectal liver metastasis. (2015)
  • Author(s): Hideki Ueno, et al
  • Journal Title: Surgery Volume: 157 Issue: 5 Pages: 899-908
  • DOI: 10.1016/j.surg.2014.12.025
  • Peer Reviewed
• [Journal Article] In rectal cancer, the type of desmoplastic response after preoperative chemoradiotherapy is associated with prognosis. (2015)
  • Author(s): Hideki Ueno, et al
  • Journal Title: Virchows Arch Volume: 466 Issue: 5 Pages: 655-663
  • DOI: 10.1245/s10434-014-4149-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel risk factors for lymph node metastasis in early invasive colorectal cancer: multi-institution pathology review (2014)
  • Author(s): Ueno H, et al.
  • Journal Title: Journal of Gastroenterology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Site-specific tumor grading system in colorectal cancer: multicenter pathologic review of the value of quantifying poorly differentiated clusters. (2014)
  • Author(s): Ueno H, Hase K, Hashiguchi Y, Shimazaki H, Tanaka M, Miyake O, Masaki T, Shimada Y, Kinugasa Y, Mori Y, Kishimoto M, Kameoka S, Sato Y, Matsuda K, Nakadoi K, Shinto E, Nakamura T, Sugihara K.
  • Journal Title: Am J Surg Pathol Volume: 38 Issue: 2 Pages: 197-204
  • DOI: 10.1097/pas.0000000000000113
  • Peer Reviewed
• [Journal Article] Peritumoral deposits as an adverse prognostic indicator of colorectal cancer. (2014)
  • Author(s): Ueno H, Hashiguchi Y, Shimazaki H, Shinto E, Kajiwara Y, Nakanishi K, Kato K, Maekawa K, Nakamura T, Yamamoto J, Hase K.
  • Journal Title: Am J Surg. Volume: 207 Issue: 1 Pages: 70-7
  • DOI: 10.1016/j.amjsurg.2013.04.009
  • Peer Reviewed
• [Journal Article] Histological categorization of fibrotic cancer stroma in the primary tumor is an independent prognostic index in resectable colorectal liver metastasis (2014)
  • Author(s): Ueno H, et al.
  • Journal Title: American Journal of Surgical Pathology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Potential causes of stage migration and their prognostic implications in colon cancer: a nationalwide survey of specialist institutions in Japan (2014)
  • Author(s): Ueno H, et al.
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Objective Criteria for Crohn-like Lymphoid Reaction in Colorectal Cancer (2013)
  • Author(s): Hideki Ueno, Yojiro Hashiguchi, Hideyuki Shimazaki, Eiji Shinto, Yoshiki Kajiwara, Kuniaki Nakanishi, Kei Kato, Kazuya Maekawa, Kosuke Miyai, Takahiro Nakamura, Junji Yamamoto, Kazuo Hase
  • Journal Title: Am J Clin Pathol Volume: 139 Issue: 4 Pages: 434-441
  • DOI: 10.1309/ajcpwhueftgbwke4
  • Peer Reviewed
• [Journal Article] Characterization of perineural invasion as a component of colorectal cancer staging. (2013)
  • Author(s): Ueno H, Shirouzu K, Eishi Y, Yamada K, Kusumi T, Kushima R, Ikegami M, Murata A, Okuno K, Sato T, Ajioka Y, Ochiai A, Shimazaki H, Nakamura T, Kawachi H, Kojima M, Akagi Y, Sugihara K; Study Group for Perineural Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR).
  • Journal Title: Am J Surg Pathol Volume: 37 Issue: 10 Pages: 1542-1549
  • DOI: 10.1097/pas.0b013e318297ef6e
  • Peer Reviewed
• [Presentation] Definitions of tumor budding (2016)
  • Author(s): Hideki Ueno
  • Organizer: International tumor budding consensus conference ITBCC 2016
  • Place of Presentation: Kursaal Bern (Switzerland)
  • Year and Date: 2016-04-28
  • Int'l Joint Research / Invited
• [Presentation] Stage II大腸癌における簇出と 「低分化胞巣」の意義に関する比較 －多施設症例の解析結果より (2015)
  • Author(s): 上野秀樹、ほか
  • Organizer: 第70回日本大腸肛門病学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-11-13
• [Presentation] Stage II/III大腸癌におけるdesmoplastic reactionの形態学的分類の意義 (2015)
  • Author(s): 上野秀樹、ほか
  • Organizer: JDDW2015 (日本消化器外科学会大会)
  • Place of Presentation: 東京
  • Year and Date: 2015-10-10
• [Presentation] Multicenter pathological review for a novel histological tumor grading system based on quantifying poorly differentiated clusters in colorectal cancer (2015)
  • Author(s): Hideki Ueno, et al
  • Organizer: 10th Scientific & Annual Meeting, European Society of Coloproctology
  • Place of Presentation: Dublin
  • Year and Date: 2015-09-23
  • Int'l Joint Research
• [Presentation] 大腸癌における「低分化胞巣」に基づく組織学的grade分類の意義に関する 多施設研究 (2015)
  • Author(s): 上野秀樹、ほか
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-18
• [Presentation] 結腸癌症例における手術標本の取扱いによるstage migration
  • Author(s): 上野秀樹、ほか
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] KRAS遺伝子変異型大腸癌の 病理組織学的特徴
  • Author(s): 上野秀樹、ほか
  • Organizer: 第68回日本大腸肛門病学会学術集会
  • Place of Presentation: 東京