| Project/Area Number |
25462075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Ueno Hideki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 教授 (90597535)
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| Co-Investigator(Kenkyū-buntansha) |
石原 聡一郎 東京大学, 医学部附属病院, 講師 (00376443)
石黒 めぐみ 東京医科歯科大学, 大学院医歯学総合研究科, ジョイントリサーチ講座准教授 (10456238)
長谷 和生 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 教授 (50511268)
中村 好宏 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 進学課程, 准教授 (60415255)
金光 幸秀 国立研究開発法人国立がん研究センター, 中央病院, 科長 (60522977)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 大腸癌 / 予後 / Nomogram / 簇出 / 低分化胞巣 / 線維性癌間質 / 非連続性癌進展 / 神経浸潤 / 外科病理学 / 予後解析 |
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| Outline of Final Research Achievements |
The purpose of this study was to develop a novel prognostic prediction system in colorectal cancer (CRC) through identifying new pathological prognostic factors. We identified 5 new pathological factors with original assessment criteria, which had prognostic power superior to other conventional factors. In a multicenter database of CRC patients, we developed a prognostic prediction model (Nomogram) with favorable prognostic prediction power. It is determined that our results will be validated in a domestic multicenter clinical study and are now being fully utilized to develop study design of another clinical trial. Furthermore, a series of our results have been paid attention from the West and it has been determined to launch an international study for new pathological factors involving 8 countries. We believe our study products are expected to further contribute to the establishment of personalized CRC treatment through such domestic and international initiatives.
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