Liver repair mediated by lipid mediators

• Project/Area Number: 25462100
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kitasato University
• Principal Investigator: ITO YOSHIYA 北里大学, 医学部, 非常勤講師 (40203187)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脂質メディエーター / 肝修復 / マクロファージ / 脂質 / 肝再生 / ＢＬＴ１

Outline of Final Research Achievements

Liver injury elicited by ischemia and reperfusion is an important clinical problem after liver resection or transplantation, because the failure of liver to regenerate is considered a critical contributing factor in liver dysfunction and liver failure after liver surgery.　The present study was conducted to examine whether or not leukotriene B4 (LTB4) and its receptor BLT1 are involved in liver repair and regeneration following hepatic ischemia/reperfusion in mice. BLT1 signaling facilitates liver repair during hepatic ischemia/reperfusion through production of epidermal growth factor in recruited macrophages in injured lesion. LTB4/BLT1 signaling pathway plays a critical role in liver repair after acute liver injury.

Research Products

• [Journal Article] The Role of Vascular Endothelial Growth Factor Receptor-1 Signaling in the Recovery from Ischemia. (2015)
  • Author(s): Amano H, Kato S, Ito Y, Eshima K, Ogawa F, Takahashi R, Sekiguchi K, Tamaki H, Sakagami H, Shibuya M, Majima M.
  • Journal Title: PLoS One Volume: 10(7) Issue: 7 Pages: e0131445-e0131445
  • DOI: 10.1371/journal.pone.0131445
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. (2013)
  • Author(s): Ohkubo H., Ito Y., Minamino T., Mishima T., Hirata M., Hosono K., Shibuya M., Yokomizo T., Shimizu T., Watanabe M., Majima M.
  • Journal Title: FASEB J. Volume: 27 Issue: 8 Pages: 3132-3143
  • DOI: 10.1096/fj.13-227421
  • Peer Reviewed
• [Presentation] 血管内皮増殖因子１型受容体(VEGFR1)陽性マクロファージは肝虚血再灌流障害後の類洞再構築を増強させて肝修復を促進する (2015)
  • Author(s): 伊藤義也
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市熱田区）
  • Year and Date: 2015-04-16
• [Presentation] Role of leukotriene B4 receptor 1 (BLT1) signaling in liver repair after hepatic ischemia reperfusion injury
  • Author(s): Ohkubo H, Ito Y, Kojo K, Watanabe M, Majima M
  • Organizer: 第39回日本微小循環学会
  • Place of Presentation: 東京