| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Sex determining region Y-box 9 (SOX9) is a gene which plays a key role in the embryologic development, differentiation and maintenance of organs. In order to evaluate the potential role of SOX9 in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas, we collected 27 pathological tissues from 19 IPMN cases and assessed the expression of SOX9 by immunohistochemistry in 78 lesions. At the results, SOX9 was expressed in the normal pancreas, IPMN and invasive carcinoma. SOX9 positive cells were confined to the lower portions of the papillary structures of IPMN. However, SOX9 was expressed in the entire epithelium once the neoplasms advanced to high-grade dysplasia and invasive carcinoma. The expression pattern of SOX9 was similar to that of CD44 in a normal pancreas and IPMN. Double staining detected co-localization of SOX9 and CD44 in IPMN. In conclusions, changes in the SOX9 expression pattern may be involved in the mechanisms of the malignant progression of IPMN.
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