| Project/Area Number |
25462116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MAEYAMA Ryo 九州大学, 医学(系)研究科(研究院), 共同研究員 (10611668)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUMOTO Kazuhiro 九州大学, 大学病院, 准教授 (90253418)
TOMA Hiroki 九州大学, 医学研究院, 共同研究員 (80437780)
OHUCHIDA Kenoki 九州大学, 大学病院, 助教 (20452708)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 膵癌間質細胞 / 膵星細胞 / 抗間質薬 / ドラッグデリバリーシステム(DDS) / 癌間質相互作用 / 膵癌 / 化学療法抵抗性 / ナノカプセル / 抗繊維化薬 |
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| Outline of Final Research Achievements |
We analyzed about expression of CD146 and CD51 in pancreatic stellate cells by immunohistochemistry of human pancreatic cancer specimens. Expression of CD146 was negatively related with patients prognosis, whereas expression of CD51 was positively related. In vitro and in vivo experiments showed expression of CD146 in pancreatic stellate cells attenuated aggressiveness of cancer cells, although CD51 enhanced the tumorigenecity. Next we focused on pirfenidone and calpeptine which are known as anti-stromal drugs and their effect of pancreatic cancer tumor growth by Xenograft mouse model. These drugs showed significant reduction of fibrosis in tumor microenvironment via suppression of stellate cells, in addition they enhanced anti-tumoral effect of gemcitabine. These data indicates that targeting specific subgroup of stellate cells by anti-stromal agents could be a promising treatment.
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