| Project/Area Number |
25462135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
Oshima Hideki 名古屋大学, 医学系研究科, 准教授 (40378188)
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| Co-Investigator(Kenkyū-buntansha) |
藤本 和朗 名古屋大学, 医学部附属病院, 病院講師 (70644665)
碓氷 章彦 名古屋大学, 医学系研究科, 教授 (30283443)
成田 裕司 名古屋大学, 医学部附属病院, 講師 (60378221)
岡田 正穂 名古屋大学, 医学部附属病院, 病院助教 (20566989)
八神 啓 名古屋大学, 医学部附属病院, 病院助教 (60721818)
末永 啓人 名古屋大学, 医学部附属病院, 医員 (80718312)
緒方 藍歌 名古屋大学, 医学系研究科, 研究員 (70718311)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 心筋梗塞 / 心室中隔穿孔 / 温度応答性ポリマー / ポリ(N-イソプロピルアクリルアミド)ポリマー / 組織学的評価 |
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| Outline of Final Research Achievements |
We developed the surgical method using the temperature-responsive polymer to repair post MI ventricular septal perforation more surely. We sew a patch to repair VSP, but it is likely that suture-lines will be ruptured because infarction cardiac muscle is very fragile tissue.
In this study, we restored the tissue intensity by injecting a temperature-responsive polymer into infarction cardiac muscle, and improved the durability of damaged tissue against the stress of surgical suturing.In the in-vitro study, it became clear that tissue intensity of 3 times was obtained by injecting poly (N-isopropyl acrylic amide) (PNIPAM) polymer. In the rat MI model, thinning and tear injury of the cardiac tissue over time at the patch-suture sites were inhibited when we injected the polymer and sewed a ePTFE patch to rat infarction cardiac muscle.
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