Expanded polytetrafluoroethylene valved conduit with bulging sinuses in right ventricular outflow tract reconstruction for congenital heart defects

• Project/Area Number: 25462141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Miyazaki Takako 京都府立医科大学, 医学(系)研究科(研究院), 助教 (90405291)
• Co-Investigator(Kenkyū-buntansha): YAMAGISHI Masaaki 京都府立医科大学, 医学(系)研究科(研究員), 准教授 (40182422) ; MAEDA Yoshinobu 京都府立医科大学, 医学(系)研究科(研究員), 助教 (20438203) ; TANIGUCHI Satoshi 京都府立医科大学, 医学(系)研究科(研究員), 専攻医 (80438209)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 先天性心疾患 / 右室流出路再建 / ePTFE / 肺動脈代用弁

Outline of Final Research Achievements

We have developed a fan-shaped Expanded polytetrafluoroethylene (ePTFE) valve and an ePTFE valved conduit (diameter 6-24mm) with bulging sinuses with the aim of enhancing the long-term valve function. 881 patients had conduits with a fan-shaped ePTFE valves implanted for right ventricular outflow tract (RVOT) reconstruction at 65 Japanese institutes.Pulmonary insufficiency was mild or nonexistent in 95.5%. The pressure gradient between the right ventricle and the pulmonary artery was 13.0±12.0 mmHg. Freedom from reoperation at 5 years was 96.1%and 10 years 95.3%. So fan-shaped ePTFE valved conduits with bulging sinuses have a high freedom from reoperation and prevent pulmonary insufficiency. They represent a promising material for RVOT reconstruction.

Research Products

• [Journal Article] Smaller-Sized Expanded Polytetrafluoroethylene Conduits With a Fan-Shaped Valve and Bulging Sinuses for Right Ventricular Outflow Tract Reconstruction (2016)
  • Author(s): Eijiro Yamashita, Masaaki Yamagishi, Takako Miyazaki, Yoshinobu Maeda, Yusuke Yamamoto, Nobuyasu Kato, Satoshi Asada, Hisayuki Hongu, and Hitoshi Yaku
  • Journal Title: The Annals of Thoracic Surgery Volume: 印刷中 Issue: 4 Pages: 1336-1344
  • DOI: 10.1016/j.athoracsur.2016.03.027
  • Peer Reviewed / Open Access
• [Journal Article] Valved Polytetrafluoroethylene Conduits for Right Ventricular Outflow Tract Reconstruction (2015)
  • Author(s): Takeshi Shinkawa, Takako Miyazaki, Masaaki Yamagishi,
  • Journal Title: The Annals of Thoracic Surgery Volume: 100 Issue: 1 Pages: 129-137
  • DOI: 10.1016/j.athoracsur.2015.02.114
  • Peer Reviewed / Open Access
• [Journal Article] 再右室流出路再建術 (2013)
  • Author(s): 宮崎隆子、山岸正明
  • Journal Title: 胸部外科 Volume: 66 Pages: 670-673
• [Presentation] MAPCAに対する一期的UF時の心膜ロールによる中心肺動脈形成と姑息的右室流出路再建 (2016)
  • Author(s): 宮崎隆子、山岸正明、前田吉宣、加藤信康、浅田聡、本宮久之、夜久均
  • Organizer: 第46回日本心臓血管外科学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-02-14
• [Presentation] Smaller-sized expanded polytetrafluoroethylene conduits with a fan-shaped valve and bulging sinuses for right ventricular outflow tract reconstruction (2016)
  • Author(s): Eijiro Yamashita, Masaaki Yamagishi, Takako Miyazaki, Yoshinobu Maeda, Yusuke Yamamoto, Nobuyasu Kato, Satoshi Asada, Hisayuki Hongu, and Hitoshi Yaku
  • Organizer: STS/STSA: STS 2016
  • Place of Presentation: Phoenix, AZ, USA
  • Year and Date: 2016-01-23
  • Int'l Joint Research
• [Presentation] PTFE patch for outflow tract reconstruction (2015)
  • Author(s): Takako Miyazakim Masaaki Yamagishi
  • Organizer: World Society for Pediatric and Congenital Heart Surgery Regional Meeting
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2015-11-27
  • Int'l Joint Research / Invited
• [Presentation] PA/VSD/MAPCAに対する段階的手術時の肺血流供給源の比較検討：姑息的右室流出路再建術と体肺動脈短絡術 (2015)
  • Author(s): 加藤信康、山岸正明、宮崎隆子、前田吉宣、浅田聡、夜久均
  • Organizer: 第68回日本胸部外科学会定期学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-17
• [Presentation] 延伸加工による薄型ePTFEシートを弁尖に用いた新型fan-shaped ePTFE valved conduit の有効性に関する検討 (2015)
  • Author(s): 山本祐介、山岸正明、宮崎隆子、前田吉宣、加藤信康、浅田聡、夜久均
  • Organizer: 第68回日本胸部外科学会定期学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-17
• [Presentation] 純型肺動脈閉鎖症に対する外科的治療戦略 (2015)
  • Author(s): 宮崎隆子、山岸正明、前田吉宣、山本祐介、加藤信康、浅田聡
  • Organizer: 第51回日本日本小児循環器学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-16
• [Presentation] fan-shaped ePTFE valved conduit with bulging sinus のさらなる進化を目指して―新型導管の有効性に関する検討― (2015)
  • Author(s): 山本祐介、山岸正明、宮崎隆子、前田吉宣、加藤信康、浅田聡
  • Organizer: 第51回日本日本小児循環器学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-16
• [Presentation] Fan-shaped ePTFE valveとbulging sinus ePTFE conduit/patchを用いた右室流出路再建術の遠隔成績 －本邦63施設共同研究 (2014)
  • Author(s): 宮崎隆子
  • Organizer: 第50回日本小児循環器病学会総会
  • Place of Presentation: 岡山
• [Presentation] EXPANDED POLYTETRAFLUOROETHYLENE VALVED CONDUITS AND PATCHES WITH BULGING SINUSES AND FAN-SHAPED VALVES IN RIGHT VENTRICULAR OUTFLOW TRACT RECONSTRUCTION
  • Author(s): 宮崎隆子
  • Organizer: The 21st Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery
  • Place of Presentation: Kobe
• [Presentation] 心室中隔欠損兼肺動脈閉鎖の治療戦略
  • Author(s): 宮崎隆子
  • Organizer: 第49回日本小児循環器病学会総会
  • Place of Presentation: 東京
• [Presentation] Fallot四徴症に対する治療戦略
  • Author(s): 宮崎隆子
  • Organizer: 第66回日本胸部外科学会定期学術集会
  • Place of Presentation: 仙台