Expanded polytetrafluoroethylene valved conduit with bulging sinuses in right ventricular outflow tract reconstruction for congenital heart defects
| Project/Area Number |
25462141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Miyazaki Takako 京都府立医科大学, 医学(系)研究科(研究院), 助教 (90405291)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGISHI Masaaki 京都府立医科大学, 医学(系)研究科(研究員), 准教授 (40182422)
MAEDA Yoshinobu 京都府立医科大学, 医学(系)研究科(研究員), 助教 (20438203)
TANIGUCHI Satoshi 京都府立医科大学, 医学(系)研究科(研究員), 専攻医 (80438209)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 先天性心疾患 / 右室流出路再建 / ePTFE / 肺動脈代用弁 |
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| Outline of Final Research Achievements |
We have developed a fan-shaped Expanded polytetrafluoroethylene (ePTFE) valve and an ePTFE valved conduit (diameter 6-24mm) with bulging sinuses with the aim of enhancing the long-term valve function. 881 patients had conduits with a fan-shaped ePTFE valves implanted for right ventricular outflow tract (RVOT) reconstruction at 65 Japanese institutes.Pulmonary insufficiency was mild or nonexistent in 95.5%. The pressure gradient between the right ventricle and the pulmonary artery was 13.0±12.0 mmHg. Freedom from reoperation at 5 years was 96.1%and 10 years 95.3%. So fan-shaped ePTFE valved conduits with bulging sinuses have a high freedom from reoperation and prevent pulmonary insufficiency. They represent a promising material for RVOT reconstruction.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] Smaller-sized expanded polytetrafluoroethylene conduits with a fan-shaped valve and bulging sinuses for right ventricular outflow tract reconstruction2016
Author(s)
Eijiro Yamashita, Masaaki Yamagishi, Takako Miyazaki, Yoshinobu Maeda, Yusuke Yamamoto, Nobuyasu Kato, Satoshi Asada, Hisayuki Hongu, and Hitoshi Yaku
Organizer
STS/STSA: STS 2016
Place of Presentation
Phoenix, AZ, USA
Year and Date
2016-01-23
Related Report
Int'l Joint Research
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