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Combined Aspirin Study for Mechanical Prosthetic Valve in Kyushu and Ryukyu by Inter-University Hospital Network (ASPIRIN trial)

Research Project

Project/Area Number 25462153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

TSUDA Yuki  産業医科大学, 医学部, 講師 (50525491)

Co-Investigator(Kenkyū-buntansha) 中村 都英  宮崎大学, 医学部, 教授 (10207871)
江石 清行  長崎大学, 医歯薬学総合研究科(医学系), 教授 (20167290)
田代 忠  福岡大学, 医学部, 教授 (20268981)
尾辻 豊  産業医科大学, 医学部, 教授 (30264427)
川筋 道雄  熊本大学, 大学院生命科学研究部(医), 教授 (40135067)
國吉 幸男  琉球大学, 医学(系)研究科(研究院), 教授 (50153317)
西村 陽介  産業医科大学, 大学病院, 准教授 (50301338)
井本 浩  鹿児島大学, 医歯学域医学系, 教授 (60274461)
富永 隆治  九州大学, 医学研究院, 教授 (70136464)
田中 啓之  久留米大学, 医学部, 教授 (70197466)
森田 茂樹  佐賀大学, 医学部, 客員研究員 (70243938)
宮本 伸二  大分大学, 医学部, 教授 (70253797)
塩川 祐一  九州大学, 医学研究院, 准教授 (70457422)
坂口 尚  熊本大学, 医学部附属病院, 講師 (70346980)
塩瀬 明  九州大学, 医学(系)研究科(研究院), 教授 (30363336)
岡本 健  熊本大学, 大学院生命科学研究部(医), 助教 (20372782)
福井 寿啓  熊本大学, 大学院生命科学研究部(医), 教授 (50445045)
峰松 紀年  福岡大学, 医学部, 助教 (40555562)
西田 誉浩  佐賀大学, 医学部, 教授 (50284500)
Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords心臓弁膜症 / 人工弁置換術 / 抗血小板療法 / 日本人 / 有効性と安全性
Outline of Final Research Achievements

"ASPIRIN Trial" was a multicenter observational study. Between June 2013 and June 2016, 159 patients with mechanical valve replacement were allocated to receive treatment with warfarin alone (n=69, W group) or warfarin plus aspirin (n=90, W+A group) in nonrandomized manner. The patients were followed for a mean of 2.5 years and 3 patients were lost to follow-up. Primary endpoint (major systemic embolism and atherosclerotic events or cardiovascular death) occurred 4 patients in W group and 7 patients in W+A group (p=0.76). Secondary endpoint (all cause death, hemorrhagic events and gastrointestinal ulcer) occurred 9 patients in W group and 15 patients in W+A group (p=0.51). All cause death was not significantly different in W+A group (4 deaths) than in W group (5 deaths) (HR, 0.56; 95% CI, -0.99-0.38, log-lank test, p=0.39). Conclusion: In this study of patients with mechanical prosthetic valves, combined warfarin and aspirin did not reduce the risk of cardiovascular events.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] Combined Aspirin Study for Mechanical Prosthetic Valve In Kyushu and Ryukyu by Inter-University Hospital Network (ASPIRIN) Trial2017

    • Author(s)
      Yuki Tsuda, Yosuke Nishimura, Noritoshi Minematsu, Kiyoyuki Eishi, Yukio Kuniyoshi, Toshihiro Fukui, Hideichi Wada, Kunihide Nakamura, Yutaka Imoto, Akira Shiose, Shinji Miyamoto, Hiroyuki Tanaka, Yutaka Otsuji et. al
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県金沢市(石川県立音楽堂他)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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