| Project/Area Number |
25462173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA JUN 東京大学, 医学部附属病院, 教授 (90188954)
NAGAYAMA KAZUHIRO 東京大学, 医学部附属病院, 助教 (00647935)
北野 健太郎 東京大学, 医学部附属病院, 助教 (70647073)
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| Research Collaborator |
MURAYAMA TOMONORI 東京大学, 医学部附属病院
KAWASHIMA MITSUAKI 東京大学, 医学部附属病院
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肺移植 / 閉塞性細気管支炎 / 自然免疫 / 気道リモデリング / 急性肺傷害 / 脳死 |
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| Outline of Final Research Achievements |
We confirmed that allograft airway fibrosis was reduced in toll-like receptor 4 (TLR4) mutant recipient mouse. This result suggests that not only acquired immunity but also innate immunity including TLR4 signal transduction control allo-immune response and tissue remodeling. In future perspective, using TLR4 inhibitor may be an innovative therapeutic option to reduce allograft airway fibrosis that cannot be inhibited by already established immune-suppressants.
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