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The mechanism of metastasis of circulating tumor cells in non small cell lung cancer

Research Project

Project/Area Number 25462176
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionOsaka University

Principal Investigator

Funaki Soichiro  大阪大学, 医学(系)研究科(研究院), 助教 (50464251)

Co-Investigator(Kenkyū-buntansha) Minami Masato  大阪大学, 医学部附属病院, 准教授 (10240847)
Inoue Masayoshi  京都府立医科大学, 医学研究科, 教授 (10379232)
Okumura Meinoshin  大阪大学, 医学系研究科, 教授 (40252647)
Nakagiri Tomoyuki  大阪大学, 医学系研究科, 招へい教員 (70528710)
Shintani Yasushi  大阪大学, 医学系研究科, 准教授 (90572983)
Kawamura Tomohiro  大阪大学, 医学系研究科, 助教 (30528675)
Sawabata Noriyoshi  大阪大学, 医学系研究科, 招聘教授 (50403184)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺癌 / 遊離癌細胞 / 転移 / 循環癌細胞 / 癌
Outline of Final Research Achievements

Size-based detection method by using the filtration can detect rare circulating cancer cells (CTCs) in blood in non small lung cancer. by using this method, we can detect not only singular CTCs but also clustered CTCs, which is suggested to have high potential of distant metastasis and recurrences. The presence of clustered CTCs may be an useful prognostic indicator in surgically resected non small cell lung cancer. While, to reveal the mechanism of metastasis, we focused epithelial mesenchymal transition (EMT)which is also known to have a key process in cancer progression, and the cancer immunology, the programmed cell death 1/programmed cell death 1-ligand 1 (PD-1/PD-L1) pathway which plays a major role. Our results showed that PD-L1 expression is regulated by EMT status and plays an important role in cancer progression.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2013

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Lung excision of non-small-cell lung cancer leaves cancer cells in residual lobe: cytological detection using pulmonary vein blood.2016

    • Author(s)
      Sawabata N, Funaki S, Shintani Y, Okumura M.
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: 22 Issue: 2 Pages: 131-5

    • DOI

      10.1093/icvts/ivv301

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Global DNA hypomethylation coupled to cellular transformation and metastatic ability.2015

    • Author(s)
      Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T.
    • Journal Title

      FEBS lett.

      Volume: 589 Issue: 24PartB Pages: 4053-60

    • DOI

      10.1016/j.febslet.2015.11.020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.2015

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Issue: 13 Pages: 4086-4091

    • DOI

      10.1073/pnas.1417273112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of tumour vessel invasion in determining the morphology of isolated tumour cells in the pulmonary vein in non-small-cell lung cancer2013

    • Author(s)
      Funaki S, Sawabata N, Abulaiti A, Nakagiri T, Shintani Y, Inoue M, Minami M, Okumura M
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 43 Issue: 6 Pages: 1126-1130

    • DOI

      10.1093/ejcts/ezs553

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6.2013

    • Author(s)
      Abulaiti A, Shintani Y, Funaki S, Nakagiri T, Inoue M, Sawabata N, Minami M, Okumura M.
    • Journal Title

      Lung Cancer

      Volume: 82 Issue: 2 Pages: 204-213

    • DOI

      10.1016/j.lungcan.2013.08.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pulmonary fibroblasts induce epithelial mesenchymal transition and some characteristics of stem cells in non-small cell lung cancer.2013

    • Author(s)
      Shintani Y, Abulaiti A, Kimura T, Funaki S, Nakagiri T, Inoue M, Sawabata N, Minami M, Morii E, Okumura M.
    • Journal Title

      Ann Thorac Surg.

      Volume: 96 Issue: 2 Pages: 425-433

    • DOI

      10.1016/j.athoracsur.2013.03.092

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 胸腺腫におけるPD-L1発現の臨床学的意義2015

    • Author(s)
      舟木壮一郎、福井絵里子、川村知裕、木村 亨、新谷 康、南 正人、奥村明之進
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非小細胞肺癌におけるPodocalyxinの臨床学的意義2015

    • Author(s)
      楠本英則、新谷 康、川村知裕、舟木壮一郎、井上匡美、別所俊哉、南 正人、奥村明之進
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] ANPの血管保護作用による術後再発予防効果 -前向き多施設臨床研究開始に向けて-2015

    • Author(s)
      野尻 崇、細田洋司、徳留健、三浦浩一、新谷康、木村亨、井上匡美、南正人、竹内幸康、前田元、宮里幹也、寒川賢治、奥村明之進
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 上皮間葉転換EMTを標的とした肺癌治療の開発2015

    • Author(s)
      新谷 康、藤原綾子、木村 亨、川村知裕、舟木壮一郎、井上匡美、南 正人、奥村明之進
    • Organizer
      第68回日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinical significance of Programmed Death 1-Ligand 1(PD-L1) in human Thymic cancer2015

    • Author(s)
      舟木壮一郎、福井絵里子、川村知裕 、新谷 康、木村 亨 、南 正人、奥村明之進
    • Organizer
      第68回日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Activation of TGF β-IL6 axis mediates chemoresistance in non-small cell lung cancer by increasing epithelial-mesenchymal transition signaling2015

    • Author(s)
      Shintani Y,Funaki S, Kimura T, Fujiwara A, Kawamura T, Bessho T, Inoue M, Minami M, Okumura M
    • Organizer
      AACR annual meeting 2015
    • Place of Presentation
      Philadelphia,United States of America
    • Year and Date
      2015-04-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In the new adenocarcinoma classification, histo-pathological finding-invasion- reflects the presence of isolated tumor cells2013

    • Author(s)
      Funaki S, Sawabata N, Abulaiti A, Kawamura T Nakagiri T, Shintani Y, Inoue M, Minami M, Okumura M.
    • Organizer
      27thEuropean Association for Cardio-Thoracic Surgery
    • Place of Presentation
      Vienna(Austria)
    • Related Report
      2013 Research-status Report
  • [Presentation] 7th TNM病期分類における小型腺癌の組織分類と 臨床背景の関連性2013

    • Author(s)
      舟木 壮一郎  川村  知裕 中桐 伴行 新谷 康 井上 匡美,澤端 章好南 正人 奥村 明之進
    • Organizer
      日本呼吸器外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] エピジェネティクスな変化と癌 ‐ゲノムの低メチル化が細胞の腫瘍化に及ぼす影響2013

    • Author(s)
      舟木 壮一郎  中村 肇伸  奥村 明之進  仲野 徹
    • Organizer
      日本外科学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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