Mechanism identification and Developing a novel method for therapy against lung cancer invasion via cancer-associated fibroblasts in pulmonary emphysema
| Project/Area Number |
25462177
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory surgery
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIMOTO Arata 山口大学, 医学部附属病院, 助教 (90396325)
UEDA Kazuhiro 山口大学, 医学部附属病院, 講師 (90420520)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 肺癌 / 肺気腫 / 癌関連線維芽細胞 / 肺気腫合併肺癌 |
|---|
| Outline of Final Research Achievements |
To evaluate whether cancer-related fibroblasts are useful as a novel target for lung cancer therapy, we aimed to elucidate the characteristic of cancer-related fibroblasts in lung cancer with pulmonary emphysema and the role of cancer-related fibroblasts in lung cancer progression in the emphysema lung. We manufactured Lewis lung cancer xenograft in murine model with pulmonary emphysema and tried to identify cancer-related fibroblasts in the emphysema lung resected from this model by detecting FAP and alpha-SMA-positive cells using FACS analysis.
|
Report
(3 results)
Research Products
(2 results)
