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Mechanism identification and Developing a novel method for therapy against lung cancer invasion via cancer-associated fibroblasts in pulmonary emphysema

Research Project

Project/Area Number 25462177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionYamaguchi University

Principal Investigator

HAYASHI Masataro  山口大学, 医学部附属病院, 助教 (00554057)

Co-Investigator(Kenkyū-buntansha) NISHIMOTO Arata  山口大学, 医学部附属病院, 助教 (90396325)
UEDA Kazuhiro  山口大学, 医学部附属病院, 講師 (90420520)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺癌 / 肺気腫 / 癌関連線維芽細胞 / 肺気腫合併肺癌
Outline of Final Research Achievements

To evaluate whether cancer-related fibroblasts are useful as a novel target for lung cancer therapy, we aimed to elucidate the characteristic of cancer-related fibroblasts in lung cancer with pulmonary emphysema and the role of cancer-related fibroblasts in lung cancer progression in the emphysema lung. We manufactured Lewis lung cancer xenograft in murine model with pulmonary emphysema and tried to identify cancer-related fibroblasts in the emphysema lung resected from this model by detecting FAP and alpha-SMA-positive cells using FACS analysis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Pulmonary emphysema and tumor microenvironment in primary lung cancer2016

    • Author(s)
      Murakami J, Ueda K, Sano F, Hayashi M, Nishimoto A, Hamano K
    • Journal Title

      Journal of surgical research

      Volume: 200 Pages: 690-697

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 腫瘍間質のMMP-9高発現は肺癌の臨床病理学的悪性度に関与する; 特に肺気腫に発生した肺癌との関連について2015

    • Author(s)
      村上順一、上田和弘、佐野史歩、林雅太郎、濱野公一
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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