Preparation of the guideline for biomarkers-based personlized treatment for patients with advanced lung cancer

• Project/Area Number: 25462179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kagawa University
• Principal Investigator: Liu Dage 香川大学, 医学部, 助教 (30314941)
• Co-Investigator(Kenkyū-buntansha): Nakano Jun 香川大学, 医学部, 助教 (80437673) ; Tokunaga Masayosi 香川大学, 医学部付属病院, 助教 (20635825) ; Yokomise Hiroyasu 香川大学, 医学部, 教授 (80231728) ; Ueno Masaki 香川大学, 医学部, 教授 (30322267)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: バイオマーカー / 進行期肺癌 / 個別化治療 / 化学療法 / 抗癌剤耐性 / ガイドライン作成

Outline of Final Research Achievements

Tailor-made medicine is important for improving the result of cancer treatment. Cancer related biomarkers were comprehensively analysied and biomarkers-based chemotherapy were used into the clinical management in our institude. We tried to establish a simple and standardized [biomarkers-bassed ailor-made medicine selectting system] for widespreading the benefit of biomarkers. The in vitro 3D drug sensitivity test (CD-DST method) and prespective study were performed to verification of the value of biomarkers. These results of our study have been adopted by domestic and international conferences, and the usefness of biomarkers-bassed ailor-made medicine for patients with advanced-stage lung cancer was appealled abroad.

Research Products

• [Journal Article] G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells (2015)
  • Author(s): Zhang, X.; Liu, D.; Hayashida, Y.; Okazoe, H.; Hashimoto, T.; Ueda, N.; Sugimoto, M.; Kakehi, Y.,
  • Journal Title: Int J Mol Sci Volume: 16 Issue: 10 Pages: 24319-31
  • DOI: 10.3390/ijms161024319
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potent effect of adenoviral vector expressing short hairpin RNA targeting ribonucleotide reductase large subunit M1 on cell viability and chemotherapeutic sensitivity to gemcitabine in non-small cell lung cancer cells (2015)
  • Author(s): Tokunaga, Y. Liu, D. Nakano, J. Zhang, X. Nii, K.; Go, T. Huang, C. L. Yokomise, H.
  • Journal Title: Eur J Cancer Volume: 51 Issue: 16 Pages: 2480-9
  • DOI: 10.1016/j.ejca.2015.05.013
  • Peer Reviewed / Open Access
• [Journal Article] Expression and Role of GPR87 in Urothelial Carcinoma of the Bladder. (2013)
  • Author(s): Okazoe H, Zhang X, Liu D, Shibuya S, Ueda N, Sugimoto M, Kakehi Y.
  • Journal Title: Int J Mol Sci. Volume: 14(6) Issue: 6 Pages: 12367-79
  • DOI: 10.3390/ijms140612367
  • Peer Reviewed
• [Journal Article] Chemotherapy followed by surgery on the basis of biomarker examination for patients with advanced non-small cell lung cancer. (2013)
  • Author(s): Yokomise H, Liu D, Ishikawa S, Go T, Gotoh M, Okuda M, Tarumi S, Kasai Y, Matsuura N.
  • Journal Title: Anticancer Res. Volume: 33(12) Pages: 5597-602
  • Peer Reviewed
• [Presentation] Verification of biomarkers in predicting drug sensitivity with in vitro 3D drug sensitivity test in non- small cell lung cancer (2016)
  • Author(s): Dage Liu, Nariyasu Nakashima, Yoshuke Kita, Yoshimasa Tokunaga, Kazuhito Nii, Natsumi Matsuura, Jun Nakano, Shintaro Tarumi, Masaya Okuda, Tetsuhiko Go, Xia Zhang, Yoshiyuki Kakehi, Hiroyasu Yokomise
  • Organizer: 第52回米国癌治療学会議 ASCO 2016 Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-06-02
• [Presentation] Correlation among the biomarkers for Oral anti-cancer agents in lung adenocarcinoma (2016)
  • Author(s): Nariyasu Nakashima, Dage Liu, Yoshuke Kita, Yoshimasa Tokunaga, Kazuhito Nii, Natsumi Matsuura, Jun Nakano, Shintaro Tarumi, Masaya Okuda, Tetsuhiko Go, Xia Zhang, Yoshiyuki Kakehi, Hiroyasu Yokomise
  • Organizer: 第52回米国癌治療学会議 ASCO 2016 Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-06-02
• [Presentation] Adjuvant chemotherapy based on biomarker examination may improve survival in completely resected non-small cell lung cancer patients (2016)
  • Author(s): Hiroyasu Yokomise, Dage Liu, Tetsuhiko Go, Jun Nakano, Masaya Okuda, Shintaro Tarumi, Nariyasu Nakashima, Natsumi Matsuura, Kazuhito Nii, Yoshimasa Tokunaga
  • Organizer: 24th European Conference on General Thoracic Surgery
  • Place of Presentation: 24th European Conference on General Thoracic Surgery
  • Year and Date: 2016-05-29
  • Int'l Joint Research
• [Presentation] 肺腺癌における経口型治療薬のバイオマーカー測定は新しい肺癌治療の指標となりうる？ (2016)
  • Author(s): 中島成泰， 劉 大革, 池田敏裕， 横田 直哉, , 喜田 裕介, 藤原 敦史, 徳永 義昌，新居 和人, 松浦 奈都美, 垂水晋太郎, 奥田 昌也, 中野 淳, 呉 哲彦, 横見瀬 裕保
  • Organizer: 第116回日本外科学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2016-04-14
• [Presentation] RRM1抑制アデノウイルスベクターを用いた癌遺伝子治療の基礎的研究 (2015)
  • Author(s): 徳永 義昌, 劉 大革, 新居 和人, 中野 淳, 池田 敏裕, 喜田 裕介, 横田 直哉, 藤原 敦史, 松浦 奈都美, 笠井 由隆, 奥田 昌也, 後藤 正司, 呉 哲彦, 横見瀬 裕保
  • Organizer: 第56回日本肺癌学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-11-26
• [Presentation] RRM1抑制アデノウィルスベクターによるRRM1発現肺癌細胞株への抗腫瘍作用． (2015)
  • Author(s): 劉 大革, 徳永 義昌, 中野 淳, 張 霞, 喜田 裕介, 中島 成泰, 黄 政龍, 横見瀬 裕保．
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-10-08
• [Presentation] RRM1抑制アデノウィルスベクターによる癌遺伝子治療の基礎的研究 (2013)
  • Author(s): 劉大革、徳永 義昌、新居和人、張 霞、中島 成泰，石川 真也、横見瀬裕保
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜（パシフィコ）
• [Presentation] 蛋白バイオマーカーステータスに基づく3期術後補助化学療法の検討 (2013)
  • Author(s): 奥田 昌也, 伊藤 公一,加藤 歩, 徳永 義昌, 笠井 由隆, 松浦 奈都美, 中野 淳, 後藤 正司, 劉 大革, 呉 哲彦, 横見瀬 裕保
  • Organizer: 第66回日本胸部外科学会定期学術集会
  • Place of Presentation: 仙台(国際センター)
• [Presentation] 局所進行肺癌に対する導入療法：バイオマーカーを指標とするテーラーメイド治療の試み (2013)
  • Author(s): 呉 哲彦, 横見瀬 裕保, 劉 大革, 徳永 義昌, 松浦 奈都美, 奥田 昌也, 笠井 由隆, 中野 淳, 後藤 正司
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: 東京(ホテルニューオータニ）