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Immunoescape from innnate/adoptive antitumor immunity via EGF family receptor in non-small cell lung cancer

Research Project

Project/Area Number 25462189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionKawasaki Medical School

Principal Investigator

Okita Riki  川崎医科大学, 医学部, 講師 (90467762)

Co-Investigator(Kenkyū-buntansha) NAKATA Masao  川崎医科大学, 医学部, 教授 (30368641)
Research Collaborator Kiessling Rolf  カロリンスカ研究所, 教授
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腫瘍免疫 / 非小細胞肺癌 / 悪性胸膜中皮腫 / NK細胞 / EGFR / HER2 / NKG2Dリガンド / NK細胞傷害活性 / 癌免疫療法 / 肺癌 / NK cell / NKG2D ligand / lung cancer
Outline of Final Research Achievements

We reported following findings. 1: EGFR/PI3K-AKT signaling regulates the expression of NKG2D ligands MICB via miR20a, resulted in enhanced NK cell-mediated cytotoxicity against non-small cell lung cancer cells. 2: Overexpression of MICA/B is independent improved prognostic factor for patients with non-small cell lung cancer. 3: EGFR/HER2 dual tyrosine kinase inhibitor lapatinib upregulates HER2, resulted in enhanced antibody dependent cellular cytotoxicity with NK cells in malignant mesothelioma cell lines.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2013 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Int'l Joint Research] Karolinska Institutet(Sweden)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Martin Luther University(Germany)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] MHC class I chain‑related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non‑small cell lung cancer2016

    • Author(s)
      Riki Okita1, Takuro Yukawa, Yuji Nojima, Ai Maeda, Shinsuke Saisho, Katsuhiko Shimizu, Masao Nakata
    • Journal Title

      Cancer Immunol Immunother

      Volume: 65 Issue: 5 Pages: 499-509

    • DOI

      10.1007/s00262-016-1814-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Contrasting effects of the cytotoxic anticancer drug Gemcitabine and the EGFR tyrosine kinase inhibitor Gefitinib on NK cell-mediated cytotoxicity via regulation of NKG2D ligand in non-small-cell lung cancer cells.2015

    • Author(s)
      Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, Shimizu K, Yamaguchi Y, Oka M, Nakayama E, Lundqvist A, Kiessling R, Seliger B, Nakata M.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: e0139809-e0139809

    • DOI

      10.1371/journal.pone.0139809

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lapatinib enhances trastuzumab-mediated antibody-dependent cellular cytotoxicity via upregulation of HER2 in malignant mesothelioma cells2015

    • Author(s)
      Riki Okita , Katsuhiko Shimizu, Yuji Nojima, Takuro Yukawa, Ai Maeda, Shinsuke Saisho, Masao Nakata.
    • Journal Title

      Oncology Reports

      Volume: 34 Issue: 6 Pages: 2864-2870

    • DOI

      10.3892/or.2015.4314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Overexpression of NK cell-activating ligand MICA/B correlates with superior outcomes and might be a therapeutic target for chemoimmunotherapy in non-small-cell lung cancer.2015

    • Author(s)
      Riki Okita, Takuro Yukawa, Yuji Nojima, Ai Maeda, Shinsuke Saisho, Katsuhiko Shimizu, Masao Nakata
    • Organizer
      ESMO Asia 2015
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非小細胞肺癌におけるNKG2DリガンドMICA/B発現の意義:切除例における予後との関連ならびにシスプラチンによるMICA/B発現誘導効果に関する検討2015

    • Author(s)
      沖田理貴、湯川拓郎、野島雄史、前田 愛、最相晋輔、清水克彦、中田昌男
    • Organizer
      第28回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      川越東武ホテル、川越市、埼玉県
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫細胞においてlapatinibはtrastuzumabの抗体依存性細胞傷害活性を増強する2015

    • Author(s)
      沖田理貴、野島雄史、前田 愛、最相晋輔、清水克彦、中田昌男
    • Organizer
      第6回 Japan Mesothelioma Interest Group 研究会
    • Place of Presentation
      北九州国際会議場、北九州市、福岡県
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lapatinib enhances trastuzumab-mediated antibody-dependent cellular cytotoxicity by upregulating HER2 in malignant pleural mesothelioma cells.2015

    • Author(s)
      Riki Okita, Shinji Nojima, Ai Maeda, Takuro Yukawa, Shinsuke Saisho, Katsuhiko Shimizu, Masao Nakata.
    • Organizer
      The 2015 European Cancer Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学療法前後における非小細胞肺癌細胞のNKG2Dリガンド発現解析2015

    • Author(s)
      沖田理貴, 保田紘一郎, 前田 愛, 湯川拓郎, 最相晋輔, 清水克彦, 中田昌男
    • Organizer
      第32回日本呼吸器外科学会総会
    • Place of Presentation
      サンポートホール高松、高松市、香川県
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Anticancer drugs effect on NK cell-mediated cytotoxicity via the regulation of NKG2D ligand expression in non-small cell lung cancer cells2013

    • Author(s)
      Okita R, Nojima Y, Yasuda K, Maeda A, Yukawa T, Saisho S, Hirami Y, Shimizu K, Nakata M
    • Organizer
      European Cancer Congress 2013
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Research-status Report
  • [Presentation] 非小細胞肺癌細胞において抗腫瘍薬がNK細胞傷害活性に与える影響の解析2013

    • Author(s)
      沖田理貴、野島雄史、保田紘一郎、前田 愛、湯川拓郎、最相晋輔、清水克彦、中田昌男
    • Organizer
      第54回日本肺癌学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] EGFR signaling effects on NK cell-mediated cytotoxicity via NKG2D ligands-NKG2D interaction in non-small cell lung cancer cells2013

    • Author(s)
      Okita R, Nojima Y, Yasuda K, Maeda A, Yukawa T, Saisho S, Hirami Y, Shimizu K, Nakata M
    • Organizer
      15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Research-status Report
  • [Remarks] 川崎医科大学呼吸器外科学教室 研究紹介

    • URL

      http://www.kawasaki-m.ac.jp/gts/07-01.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] Karolinska Institutet, Rolf Kiessling's Group

    • URL

      http://ki.se/en/onkpat/rolf-kiesslings-group

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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