| Project/Area Number |
25462217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Koji 岡山大学, 医歯薬学総合研究科, 准教授 (40294467)
KAMEDA Masahiro 岡山大学, 医歯薬学総合研究科, 助教 (50586427)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 医歯薬学総合研究科, 教授 (70236785)
TAKEDA Yoshimasa 岡山大学, 大学病院, 准教授 (30294466)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | くも膜下出血 / 拡延性抑制 / NADH |
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| Outline of Final Research Achievements |
Changes in DC potential were categorized into three groups. In type 1, ischemic depolarization was not observed during one-hour of observation period. In type 2, DC potential showed ischemic depolarization upon initiation of SAH and recovered to 80% from maximal DC deflection during one-hour of observation period (33.3 ± 15.8 min). In type 3, DC potential showed ischemic depolarization and did not recover during one-hour of observation period. Based on histological evaluation at the DC recording sites, all sites in the type 1 group showed intact histology. In the type 2 and type 3 groups, neuronal damage of varying severity was observed depending on the duration of ischemic depolarization. The duration of depolarization that causes 50% neuronal injury (P50) was estimated at 22.4 minutes. CSD was successfully visualized using NADH fluorescence. CSD was not associated with histological damage in current experimental setting.
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