Assessment of impact of spreading depolarization during acute phase of subarachnoid hemorrhage model in rats
| Project/Area Number |
25462217
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Koji 岡山大学, 医歯薬学総合研究科, 准教授 (40294467)
KAMEDA Masahiro 岡山大学, 医歯薬学総合研究科, 助教 (50586427)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 医歯薬学総合研究科, 教授 (70236785)
TAKEDA Yoshimasa 岡山大学, 大学病院, 准教授 (30294466)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | くも膜下出血 / 拡延性抑制 / NADH |
|---|
| Outline of Final Research Achievements |
Changes in DC potential were categorized into three groups. In type 1, ischemic depolarization was not observed during one-hour of observation period. In type 2, DC potential showed ischemic depolarization upon initiation of SAH and recovered to 80% from maximal DC deflection during one-hour of observation period (33.3 ± 15.8 min). In type 3, DC potential showed ischemic depolarization and did not recover during one-hour of observation period. Based on histological evaluation at the DC recording sites, all sites in the type 1 group showed intact histology. In the type 2 and type 3 groups, neuronal damage of varying severity was observed depending on the duration of ischemic depolarization. The duration of depolarization that causes 50% neuronal injury (P50) was estimated at 22.4 minutes. CSD was successfully visualized using NADH fluorescence. CSD was not associated with histological damage in current experimental setting.
|
Report
(3 results)
Research Products
(79 results)
-
-
-
-
[Journal Article] For U.J., Investigators U.I. Risk of rupture of unruptured cerebral aneurysms in elderly patients.2015
Author(s)
Hishikawa T., Date I., Tokunaga K., Tominari S., Nozaki K., Shiokawa Y., Houkin K., Murayama Y., Ishibashi T., Takao H., Kimura T., Nakayama T., Morita A.
-
Journal Title
Neurology
Volume: 85
Issue: 21
Pages: 1879-1885
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Cerebrovascular surgery in Hybrid OR in Japan2015
Author(s)
Hishikawa T, Sugiu K, Date I
Organizer
Consortium of Orchestrated Approach for Cardio-cerebro-vascular disease Treatment (COAST) 1st International Symposium
Place of Presentation
Seoul, Korea
Year and Date
2015-12-09
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Effect of anti-high mobility group box-1 monoclonal antibody on delayed cerebral vasospasm following subarachnoid hemorrhage in rats2015
Author(s)
Haruma J , Hishikawa T , Ryu K , Nishihiro S , Shinji Y , Takasugi Y , Hiramatsu M , Sugiu K , Nishibori M , Date I
Organizer
13th International Conference on Neurovascular Events after Subarachnoid Hemorrhage: Vasospasm 2015
Place of Presentation
Karuizawa, Japan
Year and Date
2015-09-17
Related Report
Int'l Joint Research
-
[Presentation] Assessment of membrane depolarization on brain cortex during acute phase of subarachnoid hemorrhage in rats2015
Author(s)
Takasugi Y , Hishikawa T , Shimizu T , Nishihiro S , Shinji Y , Haruma J , Hiramatsu M , Sugiu K , Takeda Y , Morimatu H , Date I
Organizer
13th International Conference on Neurovascular Events after Subarachnoid Hemorrhage: Vasospasm 2015
Place of Presentation
Karuizawa, Japan
Year and Date
2015-09-17
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
