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A novel treatment strategy of angiogenesis inhibition targeting for aquaporin-1 in intractable benign brain tumors

Research Project

Project/Area Number 25462248
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKanazawa University

Principal Investigator

Hayashi Yasuhiko  金沢大学, 大学病院, 講師 (50324124)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords良性脳腫瘍 / 水チャンネル / 細胞性浮腫 / 血管新生 / 解糖系 / 下垂体腺腫 / 選択的水チャンネル / 血管内皮細胞 / 脳腫瘍 / アクアポーリン
Outline of Final Research Achievements

A selective water channel, aquaporin (AQP), does not exist on tumor cells of benign brain tumors, but it is abundantly expressed on endothelial cells of vasculature of the tumors. This is the opposite relationship compared to malignant brain tumors, in which AQP-1 exist on tumor cells not on endothelial cells of vasculature. Malignant brain tumors have extensive necrosis in the core, which is attributed to the inhibition of angiogenesis due to glycolysis-induced cytotoxic edema. AQP-1 over expressed cultured benign brain tumor cells facilitate cell growth aggressively. On the other hand, AQP-1 in endothelial cells relieve the glycolysis-induced cytotoxic edema effectively, leading to the angiogenesis. Consequently, if AQP-1 in the endothelial cells can be inhibited by some drugs, it would be novel treatment for intractable benign brain tumors.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 2014 2013

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Significant improvement of intractable headache after transsphenoidal surgery in patients with pituitary adenomas; preoperative neuroradiological evaluation and intraoperative intrasellar pressure measurement.2016

    • Author(s)
      Hayashi Y, Kita D, Iwato M, Fukui I, Oishi M, Tsutsui T, Tachibana O, Nakada M.
    • Journal Title

      Pituitary

      Volume: 19 Issue: 2 Pages: 175-182

    • DOI

      10.1007/s11102-015-0696-8

    • NAID

      120005708418

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute progression of recurrent meningioma during luteinizing hormone-releasing hormone agonist treatment for prostate cancer.2016

    • Author(s)
      Tsutsui T, Miyashita K, Sabit H, Fukui I, Hayashi Y, Mizokami A, Ikeda H, Nagatani H, Nakada M
    • Journal Title

      World Neurosurgery

      Volume: 印刷中 Pages: 670.e1-670.e6

    • DOI

      10.1016/j.wneu.2016.03.076

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Massive Hemorrhage from the Posterior Ethmoidal Artery during Transsphenoidal Surgery2015

    • Author(s)
      Hayashi Y, Kita D, Iwato M, Nakanishi S, Hamada J
    • Journal Title

      Turkish Neurosurgery

      Volume: 25 Pages: 804-807

    • DOI

      10.5137/1019-5149.jtn.11013-14.0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 11. Pure Lymphocytic Infundibuloneurohypophysitis Caused by the Rupture of Rathke's Cleft Cyst2015

    • Author(s)
      Hayashi Y, Oishi M, Kita D, Watanabe T, Tachibana O, Hamada J
    • Journal Title

      Turk Neurosurgery

      Volume: 25 Pages: 332-336

    • DOI

      10.5137/1019-5149.jtn.9776-13.0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Symptomatic foramen of Magendie arachnoid cyst in an elderly patient2015

    • Author(s)
      Y. Hayashi, D. Kita, T. Watanabe, A. Yoshikawa and J. Hamada
    • Journal Title

      Surgical Neurology International

      Volume: 6 Issue: 1 Pages: 6-7

    • DOI

      10.4103/2152-7806.149611

    • NAID

      120005613976

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of late-onset idiopathic aqueductal stenosis development by magnetic resonance images2014

    • Author(s)
      Kita D, Hayashi Y, Kitabayashi T, Kinoshita M, Okajima M, Hamada JI
    • Journal Title

      Child Nervous System

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pure lymphocytic infundibuloneurohypophysitis caused by the rupture of Rathke’s cleft cyst; report of two cases and review of the literature2014

    • Author(s)
      Hayashi Y, Oishi M, Kita D, Watanabe T, Tachibana O, Hamada JI
    • Journal Title

      Turkish Neurosurgery

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adenoid cystic carcinoma in the cavernous sinus diagnosed with endoscopic endonasal approach2014

    • Author(s)
      Hayashi Y, Iwato M, Kita D, Miyashita K, Yoshizaki T, Hamada JI
    • Journal Title

      Turkish Neurosurgery

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラトケ嚢胞に対する嚢胞開放術前後の内分泌機能の変化2013

    • Author(s)
      林 康彦、喜多大輔、林 裕、立花 修、濵田潤一郎
    • Journal Title

      日本内分泌学会雑誌

      Volume: 89 Pages: 46-49

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] キアリ奇形I型における歯突起後方の軟部組織の肥厚2013

    • Author(s)
      林 康彦、喜多大輔、大石正博、濵田潤一郎
    • Journal Title

      キアリ奇形I型における歯突起後方の軟部組織の肥厚

      Volume: 38 Pages: 227-232

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 鞍結節髄膜腫に対する拡大経蝶形骨洞アプローチの側方操作2015

    • Author(s)
      林 康彦、福井一生、喜多大輔、大石正博、笹川泰生、立花 修、中田光俊
    • Organizer
      第22回日本神経内視鏡学会
    • Place of Presentation
      ホテル松島大観荘(宮城県、宮城郡松島町)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下垂体腺腫内出血の症状発現を規定する腺腫と周囲構造の因子2015

    • Author(s)
      林 康彦、福井一生、大石正博、喜多大輔、植田文明、立花 修、中田光俊
    • Organizer
      第74回日本脳神経外科学会総会
    • Place of Presentation
      ロイトン札幌(北海道、札幌市中央区北1条西)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当科における頭蓋咽頭腫に対する内視鏡下拡大蝶形骨洞アプローチ2015

    • Author(s)
      林 康彦、福井一生、喜多大輔、笹川泰生、立花 修、中田光俊
    • Organizer
      第21回北陸間脳下垂体腫瘍研究会
    • Place of Presentation
      福井フェニックスホテル(福井県、福井市大手町)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Possible participation of sphenoid sinus anatomy and dura integrity in extension of pituitary macroadenoma.2015

    • Author(s)
      Yasuhiko Hayashi, Daisuke Kita, Issei Fukui, Masahiro Oishi, Osamu Tachibana, Yutaka Hayashi.
    • Organizer
      American Association of Neurological Surgeons Annual Meeting 2015
    • Place of Presentation
      Convention Center (Washington DC, USA)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 内視鏡下経鼻的下垂体腫瘍摘出術における蝶形骨洞内構造の解剖学的指標の検討2015

    • Author(s)
      林 康彦、喜多大輔、岩戸雅之、福井一生、立花 修、中田光俊
    • Organizer
      第29回日本微小脳神経外科解剖研究会
    • Place of Presentation
      京都テルサ(京都府、京都市南区東九条下殿田町)
    • Year and Date
      2015-04-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 間脳下垂体腫瘍と中枢性尿崩症2013

    • Author(s)
      林 康彦、喜多大輔、濵田潤一郎
    • Organizer
      下垂体機能フォーラム
    • Place of Presentation
      金沢ニューグランドホテル(金沢)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 小児における症候性ラトケ嚢胞2013

    • Author(s)
      林 康彦、喜多大輔、中田光俊、立花 修、林 裕、濱田潤一郎
    • Organizer
      日本小児神経外科
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] 成長ホルモン産生性腺腫における再手術の有効性の検討2013

    • Author(s)
      林 康彦、喜多大輔、福井一生、林 裕、立花 修、濵田潤一郎
    • Organizer
      北陸間脳下垂体腫瘍研究会
    • Place of Presentation
      ホテルグランテラス富山(富山)
    • Related Report
      2013 Research-status Report
  • [Presentation] 難治性頭痛のみで発症した下垂体腺腫2013

    • Author(s)
      林 康彦、喜多大輔、岩戸雅之、立花 修、林 裕、濵田潤一郎
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] 鞍底硬膜の“midline filum” 正中の指標としての洞内隔壁との関係2013

    • Author(s)
      林 康彦、喜多大輔、福井一生、立花 修、濵田潤一郎
    • Organizer
      日本神経内視鏡学会
    • Place of Presentation
      富士屋ホテル(甲府)
    • Related Report
      2013 Research-status Report
  • [Book] Vascular anatomy and complications of pituitary adenomas, and treatment with endoscopic endonasal transsphenoidal surgery; Pituitary Adenoma: Pathophysiology, Diagnosis and Treatment Options2016

    • Author(s)
      Yasuhiko Hayashi
    • Total Pages
      20
    • Publisher
      Nova Science Publishers
    • Related Report
      2015 Annual Research Report
  • [Book] Development of symptoms in arachnoid cysts; Arachnoid cyst: Pathophysiology, Diagnosis and Treatment Options2016

    • Author(s)
      Yasuhiko Hayashi
    • Total Pages
      26
    • Publisher
      Nova Science Publishers
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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