A search for regulators of global histone modification in malignant brain tumor
Project/Area Number |
25462267
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Kochi University |
Principal Investigator |
YAWATA TOSHIO 高知大学, 教育研究部医療学系臨床医学部門, 助教 (40380323)
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Co-Investigator(Kenkyū-buntansha) |
UEBA TETSUYA 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00314203)
HIGASHI YOUICHIRO 高知大学, 教育研究部医療学系基礎医学部門, 助教 (80380062)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 悪性脳腫瘍 / 幹細胞 / 代謝 / 膠芽腫 / エピジェネティクス / ヒストン |
Outline of Final Research Achievements |
CD146 was identified as a surface marker highly expressing in glioma stem cells. CD146 regulates cell growth of glioma stem cells and is highly expressed in G2/M phase and its knockdown increases the proportion of cells in G0/G1 phase. It has been revealed that mitochondrial oxidative phosphorylation is dominant in glioma stem cells in contrast to in differentiated glioma cells using mainly aerobic glycolysis. Knockdown of CD146 in glioma cells switched from aerobic glycolysis to mitochondrial oxidative phosphorylation. In addition, expression of CD146 affected histone deacetylase activity in glioma stem cells. These results suggest that CD146 expressed in glioma stem cells is related to the cell growth and glucose metabolism and may affect on HDAC activity involved in stemness and differentiation.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat2014
Author(s)
Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
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Journal Title
Neuropharmacology
Volume: 82
Pages: 19-27
DOI
Related Report
Peer Reviewed / Open Access
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