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A search for regulators of global histone modification in malignant brain tumor

Research Project

Project/Area Number 25462267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKochi University

Principal Investigator

YAWATA TOSHIO  高知大学, 教育研究部医療学系臨床医学部門, 助教 (40380323)

Co-Investigator(Kenkyū-buntansha) UEBA TETSUYA  高知大学, 教育研究部医療学系臨床医学部門, 教授 (00314203)
HIGASHI YOUICHIRO  高知大学, 教育研究部医療学系基礎医学部門, 助教 (80380062)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性脳腫瘍 / 幹細胞 / 代謝 / 膠芽腫 / エピジェネティクス / ヒストン
Outline of Final Research Achievements

CD146 was identified as a surface marker highly expressing in glioma stem cells. CD146 regulates cell growth of glioma stem cells and is highly expressed in G2/M phase and its knockdown increases the proportion of cells in G0/G1 phase. It has been revealed that mitochondrial oxidative phosphorylation is dominant in glioma stem cells in contrast to in differentiated glioma cells using mainly aerobic glycolysis. Knockdown of CD146 in glioma cells switched from aerobic glycolysis to mitochondrial oxidative phosphorylation. In addition, expression of CD146 affected histone deacetylase activity in glioma stem cells. These results suggest that CD146 expressed in glioma stem cells is related to the cell growth and glucose metabolism and may affect on HDAC activity involved in stemness and differentiation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (9 results)

  • [Journal Article] Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat.2016

    • Author(s)
      Yawata T, Higashi Y, Shimizu T, Shimizu S, Nakamura K, Taniuchi K, Ueba T, Saito M.
    • Journal Title

      Mol. Cell. Biochem.

      Volume: 411 Issue: 1-2 Pages: 201-211

    • DOI

      10.1007/s11010-015-2582-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Use of fat-suppressed T2 -weighted sagittal images after infusion of excess saline into the subarachnoid space as a new diagnostic modality for cerebrospinal fluid hypovolemia: technical note.2016

    • Author(s)
      Nakai E, Takemura M, Nonaka M, Kawanishi Y, Masahira N, Ueba T.
    • Journal Title

      J Neurosurgery

      Volume: 124 Issue: 2 Pages: 580-583

    • DOI

      10.3171/2015.2.jns142746

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat.2015

    • Author(s)
      Shimizu T, Tanaka K, Shimizu S, Higashi Y, Yawata T, Nakamura K, Taniuchi K, Ueba T, Yuri K, Saito M
    • Journal Title

      Neuropharmacology

      Volume: 95 Pages: 278-289

    • DOI

      10.1016/j.neuropharm.2015.03.034

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat2014

    • Author(s)
      Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
    • Journal Title

      Neuropharmacology

      Volume: 82 Pages: 19-27

    • DOI

      10.1016/j.neuropharm.2014.03.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of oxidative stress and 5-lipoxygenase activation by edaravone improves depressive-like behavior after concussion2014

    • Author(s)
      Higashi Y, Hoshijima M, Yawata T, Nobumoto A, Tsuda M, Shimizu T, Saito M, Ueba T
    • Journal Title

      J Neurotrauma

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficient siRNA delivery and tumor accumulation mediated by ionically cross-linked folic acid-poly(ethylene glycol)-chitosan oligosaccharide lactate nanoparticles: For the potential targeted ovarian cancer gene therapy2013

    • Author(s)
      Li SC, Yawata T, Honke K
    • Journal Title

      E. J. Pharm. Sci

      Volume: 52 Pages: 48-61

    • DOI

      10.1016/j.ejps.2013.10.011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gene therapy strategies for treating brain tumors: Retroviruses are still good candidates for therapeutic vectors.2013

    • Author(s)
      Yawata T, Shimizu K
    • Journal Title

      Open J Genet.

      Volume: 3 Issue: 02 Pages: 12-18

    • DOI

      10.4236/ojgen.2013.32a1002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 膠芽腫幹細胞で高発現するCD146による細胞周期の制御2015

    • Author(s)
      八幡俊男、東洋一郎、川西裕、中居永一、野中大伸、上羽哲也
    • Organizer
      日本脳腫瘍学会第33回学術集会
    • Place of Presentation
      グランドプリンスホテル京都, 京都市
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット視床下部室傍核へ投与されたボンベシンによる中枢性交感神経系-副腎髄質系賦活に対し脳内カンナビノイドCB1受容体は抑制性に関与する2014

    • Author(s)
      清水 孝洋、田中 健二朗、中村 久美子、谷内 恵介、清水 翔吾、八幡 俊男、東 洋一郎、上羽 哲也、横谷 邦彦、齊藤 源顕
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2013 Research-status Report
  • [Presentation] 悪性グリオーマにおける転移・浸潤関連遺伝子MCAM/CD146の発現とその役割2013

    • Author(s)
      八幡 俊男,東 洋一郎,田村 雅一,星島 陸宏, 野中 大伸, 川西 裕,竹村 光広,中居 永一,政平 訓貴,上羽 哲也
    • Organizer
      第31回日本脳腫瘍学会
    • Place of Presentation
      フェニックス・シーガイア・リゾート(宮崎)
    • Related Report
      2013 Research-status Report
  • [Presentation] 悪性グリオーマ幹細胞におけるMCAM/CD146の高発現とその浸潤における役割2013

    • Author(s)
      八幡 俊男,東 洋一郎,田村 雅一,川西 裕,政平 訓貴,清水 惠司,上羽 哲也
    • Organizer
      第51回癌治療学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭部外傷後のうつ病様行動に対するエダラボンの効果の解析2013

    • Author(s)
      東 洋一郎,星島 陸宏, 八幡 俊男,政平 訓貴,中居 永一,川西 裕,野中 大伸, 竹村 光広,上羽 哲也
    • Organizer
      第14回日本分子脳神経外科学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] 悪性グリオーマにおける転移・浸潤関連遺伝子MCAM/CD146の発現とその意義2013

    • Author(s)
      八幡 俊男,東 洋一郎,星島 陸宏,野中 大伸,川西 裕,竹村 光広,中居 永一,政平 訓貴,上羽 哲也
    • Organizer
      第14回日本分子脳神経外科学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭部外傷後うつ病発症に対する脳内亜鉛の関与2013

    • Author(s)
      東 洋一郎,星島 陸宏, 八幡 俊男,政平 訓貴,中居 永一,川西 裕,野中 大伸, 竹村 光広,上羽 哲也
    • Organizer
      第9回メタルバイオサイエンス研究会(メタルバイオサイエンス2013)
    • Place of Presentation
      静岡県立大学(静岡)
    • Related Report
      2013 Research-status Report
  • [Presentation] 悪性グリオーマ幹細胞における転移浸潤関連遺伝子MCAM/CD146の発現とその役割2013

    • Author(s)
      八幡 俊男,東 洋一郎,川西 裕,中居 永一,政平 訓貴,清水 惠司,上羽 哲也
    • Organizer
      第27回中四国脳腫瘍研究会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Related Report
      2013 Research-status Report
  • [Presentation] エダラボンは頭部外傷による軸索損傷を阻止し、記憶障害を改善する2013

    • Author(s)
      東 洋一郎,大田 学,北原 正大, 野中 大伸, 八幡 俊男,上羽 哲也
    • Organizer
      第36回日本神経科学大会(Neuro2013)
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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