Development of novel therapy for the malignant meningioma by exploration of specific gene expression

• Project/Area Number: 25462270
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kumamoto University
• Principal Investigator: Yano Shigetoshi 熊本大学, その他の研究科, 准教授 (60332871)
• Co-Investigator(Kenkyū-buntansha): Kuratsu Jun-ichi 熊本大学, 大学院生命科学研究部, 教授 (20145296) ; Nakamura Hideo 熊本大学, 医学部附属病院, 講師 (30359963) ; Hide Takuichiro 熊本大学, 医学部附属病院, 助教 (40421820) ; Makino Keishi 熊本大学, 医学部附属病院, 講師 (90381011)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 悪性髄膜腫 / マイクロRNA / 遺伝子発現 / マイクロアレイ / miRNA / 細胞増殖 / 腫瘍幹細胞 / アレイ分析

Outline of Final Research Achievements

To establish a new therapy for malignant meningioma, the specific gene in malignant meningioma such as micro RNA and specific DNA were explored.
Tow microRNA (miR488 and mrR335) and three DNA (ISLR, SDHAP1 and CNTNAP3) were expressed at a high rate.

Research Products

• [Journal Article] Quality of Life and Clinical Features of Long-Term Survivors Surgically Treated for Pediatric Craniopharyngioma (2015)
  • Author(s): Yano S, Kudo M, Hide T, Shinojima N, Makino K, Nakamura H, Kuratsu JI
  • Journal Title: World neurosurgery Volume: 85 Pages: 153-62
  • DOI: 10.1016/j.wneu.2015.08.059
  • Peer Reviewed / Open Access
• [Journal Article] A flexible endoscope-assisted interhemispheric transcallosal approach through the contralateral ventricle for the removal of a third ventricle craniopharyngioma (2015)
  • Author(s): Yano S., Hide T., Shinojima N., Ueda U., Kuratsu J
  • Journal Title: Surg Neurol Int. Volume: 5 Issue: 3 Pages: 113-6
  • DOI: 10.4103/2152-7806.153653
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of the indocyanine green fluorescence endoscope in endonasal transsphenoidal surgery. (2015)
  • Author(s): Hide T, Yano S, Shinojima N, Kuratsu J.
  • Journal Title: J Neurosurg Volume: 122 Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Can 3T MR angiography replace DSA for the identification of arteries feeding intracranial meningiomas? (2013)
  • Author(s): Uetani H, Akter M, Hirai T, Shigematsu Y, Kitajima M, Kai Y, Yano S, Nakamura H, Makino K, Azuma M, Murakami R, Yamashita Y.
  • Journal Title: American Journal of Neuroradiology Volume: 34 Issue: 4 Pages: 765-772
  • DOI: 10.3174/ajnr.a3284
  • Peer Reviewed
• [Journal Article] New treatment strategies to eradicate cancer stem cells and niches in glioblastoma. (2013)
  • Author(s): Hide T, Makino K, Nakamura H, Yano S, Anai S, Takezaki T, Kuroda J, Shinojima N, Ueda Y, Kuratsu J.
  • Journal Title: Neurol Med Chir (Tokyo). Volume: 53 Pages: 764-772
  • NAID: 10031196787
  • Peer Reviewed
• [Journal Article] A case of ecchordosis physaliphora presenting with an abducens nerve palsy: A rare symptomatic case managed with endoscopic endonasal transsphenoidal surgery (2013)
  • Author(s): Yamamoto T, Yano S, Hide T, Kuratsu J.
  • Journal Title: Surg Neurol Int. Volume: - Issue: 1 Pages: 13-13
  • DOI: 10.4103/2152-7806.106562
  • Peer Reviewed
• [Presentation] Rapid growing meningiomaの臨床像 (2015)
  • Author(s): 矢野茂敏、篠島直樹、黒田順一郎、秀 拓一郎、浜崎 禎、牧野敬史、中村英夫、倉津純一
  • Organizer: 第33回日本脳腫瘍学会
  • Place of Presentation: 京都市
  • Year and Date: 2015-12-06
• [Presentation] 内視鏡下経鼻的頭蓋底手術の最近の進歩：新機器の導入と手術成績の関連 (2015)
  • Author(s): 矢野茂敏、篠島直樹、秀 拓一郎、 倉津純一
  • Organizer: 第20回日本脳腫瘍の外科学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-09-25
• [Presentation] 頭蓋底部線維性骨異型性症に対する経鼻内視鏡手術-開頭術同時併用手術の有用性- (2015)
  • Author(s): 矢野茂敏、篠島直樹、秀 拓一郎、倉津純一 、讃岐徹治、草場雄基、湯本英二
  • Organizer: 第27回日本頭蓋底外科学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-07-09
• [Presentation] Ｅｎｄｏｓｃｏｐｉｃ ｓｋｕｌｌ ｂａｓｅ ｓｕｒｇｅｒｙ－治療成績と最近の工夫－ (2013)
  • Author(s): 矢野茂敏、秀 拓一郎、倉津純一
  • Organizer: 第２５回日本頭蓋底外科学会
  • Place of Presentation: 名古屋（名古屋東急ホテル）
• [Presentation] 頭蓋咽頭腫術後長期生存者における健康度調査に基づく治療戦略の検討 (2013)
  • Author(s): 矢野茂敏、秀 拓一郎、牧野敬史、中村英夫、浜崎 禎、黒田順一郎、篠島直樹、倉津純一
  • Organizer: 第７２回日本脳神経外科総会
  • Place of Presentation: 横浜（パシフィコ横浜）