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Endocrinological analysis of SOX2 positive cells in pituitary adenoma

Research Project

Project/Area Number 25462276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKagoshima University

Principal Investigator

Yunoue Shunji  鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (20404478)

Co-Investigator(Kenkyū-buntansha) Arita Kazunori  鹿児島大学, 医歯学域医学系, 教授 (90212646)
Hirano Hirofumi  鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (00264416)
Takano Kouji  北里大学, 医学部, 准教授 (20236243)
OYOSHI Tatsuki  鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (80315407)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords下垂体腺腫 / SOX2 / SOX2 / 幹細胞
Outline of Final Research Achievements

Recent study revealed that SOX2 protein was transcriptional factor that contributed a development of pituitary gland. Therefore, we speculated that SOX2 positive cells play an important role in endocrinologic phenotypes of pituitary adenoma.
In this study, we show that the pituitary adenoma contains a small population of SOX2 positive cells that, is preferentially present in functioning adenoma. But, SOX2 positive cell is not hormone producing cells.
We hypothesized that SOX2 positive cells in pituitary adenoma also maintain the tumor, that these cell is present as a reserve of hormone producing cells or flicullostellate cells. To elucidate the role of SOX2 positive cells in pituitary adenoma, further study is necessary.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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