| Project/Area Number |
25462299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Mikami Yasuo 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80360030)
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| Co-Investigator(Kenkyū-buntansha) |
池田 巧 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40453120)
長江 将輝 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60604303)
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| Research Collaborator |
ISHIBASHI HIDENOBU 京都府立医科大学, 医学研究科, 大学院生
SAKATA MUNEHIRO 京都府立医科大学, 医学研究科, 大学院生
ITSUJI TOMONORI 京都府立医科大学, 医学研究科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 椎間板変性抑制 / mTOR / HGF/c-Met / 椎間板 / アポトーシス / ｍTOR / オートファジー / 抗アポトーシス効果 |
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| Outline of Final Research Achievements |
In this study, we investigated the effects of HGF/c-Met signaling on NP cell abnormality caused by using primary NP cells isolated from rabbit IVD. HGF significantly enhanced the proliferation of NP cells. Apoptosis of NP cells was significantly inhibited by HGF/c-Met signaling. Induction of the inflammation mediators was significantly suppressed by HGF/c-Met signaling. These findings demonstrate that activation of HGF/c-Met signaling suppresses various damages in NP cells. We suggest the clinical potential of HGF for counteracting IVD degradation involved in NP cell abnormalities.
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