| Project/Area Number |
25462312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
澤地 恭昇 東京医科大学, 医学部, 助教(特任) (20571152)
遠藤 健司 東京医科大学, 医学部, 講師 (90266479)
小坂 泰一 東京医科大学, 医学部, 講師 (10328213)
山本 謙吾 東京医科大学, 医学部, 主任教授 (10246316)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 椎間板性腰痛 / 椎間板変性 / 神経侵入 / プロスタノイド / 神経成長因子 / 細胞外基質分解酵素 / 細胞内情報伝達 / プロスタグランジン / MAP kinase / 神経進入 |
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| Outline of Final Research Achievements |
The molecular mechanism of developing low back pain is known as disc degeneration by MMP and following nerve innervation by NGF. The effect of selective COX-2 inhibitors, which is clinically used for the conservative treatment of low back pain, on NGF and MMP expression was investigated in human lumbar intervertebral disc (IVD) cells. IL-1-induced NGF and MMP expressions were enhanced by selective COX-2 inhibitors, on the other hand, these expressions were suppressed by PGE2, PGE1 and its derivative limaprost via EP4 receptor. Our findings would be of importance when choosing drugs for the conservative treatment of low back pain.
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