Study of the factors associated with a cause and progression of idiopathic scoliosis

• Project/Area Number: 25462318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Spinal Injuries Center
• Principal Investigator: MAEDA TAKESHI 独立行政法人労働者健康福祉機構総合せき損センター(研究部), その他部局等, 研究員 (80315077)
• Co-Investigator(Renkei-kenkyūsha): OKADA SEIJI 九州大学, 医学研究院, 准教授 (30448435)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 特発性側弯症 / メカニズム１

Outline of Final Research Achievements

The factors associated with a cause and progression of idiopathic scoliosis remain unclear. We examined the relationship between the anteroposterior chest dimension and the Cobb angle in thoracic scoliosis patients, and found that there was a significant correlation between them. We further demonstrated that a rib cage deformity with an imbalanced load to the vertebral body resulted in progressive structural scoliosis by using mice model.

Research Products

• [Journal Article] Rapid progressive clinical deterioration of cervical spondylotic myelopathy. (2015)
  • Author(s): Morishita Y, et al.
  • Journal Title: Spinal Cord Volume: 53(5) Issue: 5 Pages: 408-12
  • DOI: 10.1038/sc.2014.137
  • Peer Reviewed
• [Journal Article] Effect of preservation of the C-6 spinous process and its paraspinal muscular attachment on the prevention of postoperative axial neck pain in C3-6 laminoplasty. (2015)
  • Author(s): Mori E, Ueta T, Maeda T, Yugue I, Kawano O, Shiba K.
  • Journal Title: J Neurosurg Spine. Volume: 22 Issue: 3 Pages: 221-9
  • DOI: 10.3171/2014.11.spine131153
  • Peer Reviewed
• [Journal Article] Radiological outcome of short segment posterior instrumentation and fusion for thoracolumbar burst fractures. (2015)
  • Author(s): Vu TT, Morishita Y, et al
  • Journal Title: Asian Spine J. Volume: 9(3) Issue: 3 Pages: 427-32
  • DOI: 10.4184/asj.2015.9.3.427
  • Peer Reviewed
• [Journal Article] Influence of Spinal Cord Compression and Traumatic Force on the Severity of Cervical Spinal Cord Injury Associated With Ossification of the Posterior Longitudinal Ligament. (2014)
  • Author(s): Kawano O, Maeda T, Mori E, Yugue I, Takao T, Sakai H, Ueta T, Shiba K.
  • Journal Title: Spine. Volume: in press
  • Peer Reviewed
• [Journal Article] Subarachnoid-subarachnoid bypass: a new surgical technique for posttraumatic syringomyelia. (2013)
  • Author(s): Hayashi T, Ueta T, Kubo M, Maeda T, Shiba K.
  • Journal Title: J Neurosurg Spine. Volume: 18 Pages: 382-387
  • Peer Reviewed
• [Journal Article] Dynamic somatosensory evoked potentials to determine electrophysiological effects on the spinal cord during cervical spine extension (2013)
  • Author(s): Morishita Y, Maeda T, Ueta T, Naito M, Shiba K.
  • Journal Title: J Neurosurg Spine. Volume: 19 Pages: 288-292
  • Peer Reviewed
• [Presentation] 当院における脊髄髄膜腫の術後成績 (2015)
  • Author(s): 飯田圭一郎、河野 修、前田 健、植田 尊善、芝 啓一郎
  • Organizer: 第50回日本脊髄障害医学会
  • Place of Presentation: 東京都
  • Year and Date: 2015-11-19
• [Presentation] 胸椎椎間板ヘルニアに対する後方法固定術の手術成績 (2015)
  • Author(s): 森 英治、前田 健、弓削 至、河野 修、植田 尊善、芝 啓一郎
  • Organizer: 第50回日本脊髄障害医学会
  • Place of Presentation: 東京都
  • Year and Date: 2015-11-19
• [Presentation] 頚髄損傷患者における嚥下障害の危険因子 (2015)
  • Author(s): 林 哲生、坂井 宏旭、出田 良輔、植田 尊善、前田 健、芝 啓一郎
  • Organizer: 第50回日本脊髄障害医学会
  • Place of Presentation: 東京都
  • Year and Date: 2015-11-19
• [Presentation] 非骨傷性頚髄損傷における椎間不安定性の経時的変化と臨床経過 (2013)
  • Author(s): 前田健、植田尊善、森英治、弓削至、河野修、高尾恒彰、坂井宏旭、益田宗彰、森下雄一郎、松下昌史、芝啓一郎
  • Organizer: 第42回日本脊椎脊髄病学会
  • Place of Presentation: 沖縄県宜野湾市