| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
There was no correlation between the expression of autophagy-related protein and acetylation of the histone. I was able to confirm that quantity of population of G2/M increased by SAHA. However, there was no correlation between G2/M introduction time and LC3-2 expression increasing time. SAHA induced the formation of autophagosome in a cell. I observed the period of the formation of autophagosome , there was no tendency of this period. I tried the making of the multidrug-resistant osteosarcoma cell animal model using osteosarcoma cell line: Saos2, but this cell line died the concentration of 25 ng/ml Dox. We could not make the multidrug-resistant Saos2 cell line.
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