| Project/Area Number |
25462352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MARUMO KEISHI 東京慈恵会医科大学, 医学部, 教授 (70199925)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO MITSURU 東京慈恵会医科大学, 医学部, 准教授 (50301528)
KUROSAKA DAIZABURO 東京慈恵会医科大学, 医学部, 助教 (80297382)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | チタン再繊維 / 靱帯・骨接合部 / 再建靱帯 / ミニブタ / チタン細繊維 / 円筒形チタン細繊維 / ACL再建術 |
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| Outline of Final Research Achievements |
Anterior cruciate ligament (ACL) reconstructions using autologous tendon tissue reinforced by tubular titanium web (TW) of titanium microfibers were performed in knee joints of miniature swine. At 4 and 15 weeks, tendon/ligament maturation in the reconstructed ACLs (r-ACL) was observed; this indicated that TW facilitates attachment of tendon/ligament and bone. Furthermore, maturation process of collagen, the main structural element of bony- and tendon-like tissue forming within the titanium web was not impaired and normal patterns of tissue-specific collagen cross-links were found within the tissue matrix. These findings confirm that TW is an effective material for reconstructions of tendon/ligament-bone junctions.
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