The Shivering Threshold with various antiemetics in Rabbits.
| Project/Area Number |
25462428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWASHITA Hironobu 山梨大学, 総合研究部, 助教 (10232670)
MATSUKAWA Takashi 山梨大学, 総合研究部, 教授 (80209519)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 体温 / シバリング / 制吐薬 |
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| Outline of Final Research Achievements |
Perioperative hypothermia is common and causes numerous serious complications. On the other hand, since nausea and vomit often happens, there are a lot of chances to administrate antiemetic in perioperative period. Droperidol and Travelmin® are usually used as an antiemetic in perioperative period. Travelmin® is composed of diphenhydramine hydorochloride and diprophylline. We evaluated the effect of droperidol and Travelmin® on the shivering threshold in rabbits, since the shivering thresholds in rabbits have been researched in our laboratory for years.
High-dose droperidol significantly reduces the shivering threshold in rabbits. Droperidol should prevent or treat shivering after surgery or during induction of therapeutic hypothermia. Travelmin® did not change the shivering threshold in rabbits. We cannot expect Travelmin® as a suppressing agent of shivering.
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Report
(3 results)
Research Products
(4 results)
