| Project/Area Number |
25462435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Osaka University |
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Principal Investigator |
TANAKA TATSUYA 大阪大学, 医学部, 技術専門職員 (20645204)
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| Co-Investigator(Kenkyū-buntansha) |
中江 文 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (60379170)
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| Research Collaborator |
NAKAI Kunihiro 福井大学, 医学部附属病院, 准教授
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 疼痛モデル / マイクロRNA / 疼痛 / マイクロＲＮＡ / 神経障害性疼痛モデル / バイオマーカー |
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| Outline of Final Research Achievements |
The aim of this study was to develop pain biomarkers on microRNAs in the brain. The post-operative persistent pain (PPP) model, recently developed recently by our group was utilized in this study. After confirming the pain-related behavior of this PPP model both in the acute phase (2days postoperatively) and in the chronic phase (28the postoperative day), and the whole brain samples were taken. The cluster analysis (Ward’s method ) using Day2 and Day 28 samples revealed that by using only five kinds of microRNA, the two different conditions (acute and chronic pain) can be successfully distinguished by the first branch of this analysis. The PPP models’ brain changed from acute phase to chronic phase. This may explain that only five different kinds of micro RNA are responsible for this change.
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