The restoring effect of anesthetics on damaged-endothelial glycocalyx
| Project/Area Number |
25462444
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Edanaga Mitsutaka 札幌医科大学, 医学部, 講師 (70616169)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グリコカリックス / 麻酔薬 / 血管内皮 |
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| Outline of Final Research Achievements |
The healthy vascular endothelium is coated by endothelial glucocalyx that has several functions including an inert barrier, active reservoir, and mechanotransduction. From the viewpoint of preserve endothelial glycocalyx, the effect of anesthetics on endothelium-dependent vasodilation remains unclear. This study investigated the effect of anesthetics on endothelium-dependent vasodilation when endothelial glycocalyx damaged.
Endothelium-dependent vasodilation was significantly inhibited by sialidase which digests glycocalyx component. Sevoflurane restored this inhibition of endothelium-dependent vasodilation significantly.
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Report
(3 results)
Research Products
(2 results)
