Effect of decreasing swelling by CRPS drug in animal model

• Project/Area Number: 25462452
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: International University of Health and Welfare (2015-2016); Keio University (2013)
• Principal Investigator: Nakamura Toshiyasu 国際医療福祉大学, 臨床医学研究センター, 教授 (70265859)
• Co-Investigator(Kenkyū-buntansha): 押尾 晃一 慶應義塾大学, 医学部(信濃町), 講師 (90185588)
• Research Collaborator: YAMABE Eiko ; ABE Koji
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性疼痛 / 末梢浮腫 / 拡散強調現象 / 磁気共鳴現象 / 慢性疼痛治療薬 / 異痛 / 神経損傷 / 異常痛

Outline of Final Research Achievements

We analyzed effect of Neurotropin, pregabalin and lidocaine in decrease of ADC and T2s of target organ in diffuion MR spectroscopy in chronic pain animal model (Chang model) to examine decrease of swelling. Changes of allodynia of lower extremity was also examined in the same animals. Allodynia increased 1 day after ligation of the L4 nerve root. Neurotropin decreased allodynia well while pregabalin and lidocaine had not changed allodynia. ADC and T2s had not changed with drugs application. Real-time PCR indicated no changes on TGF-a while decreased in VEGF that can suggest vascular disorder in lower extremity in chronic pain syndrome. Vascular conduction may be effective in edema of CRPS patients.

Research Products

• [Presentation] Line Scan Diffusion Spectrum of the Rat CRPS Model (2015)
  • Author(s): Abe Y, Nakamura T, Yamabe E, Toyama Y
  • Organizer: 6th Combined Meeting of the ASSH and JSSH
  • Place of Presentation: Maui, Hawaii, USA
  • Year and Date: 2015-04-01
  • Int'l Joint Research
• [Presentation] Line scan diffusion spectrum of the rat skeletal muscle of neuropathic model. (2014)
  • Author(s): Abe K, Nakamura T, Yamabe E, Toyama Y
  • Organizer: American Association for Hand Surgery
  • Place of Presentation: Kauai, USA