Comprehensive analysis of neuropathic pain-specific microRNA cluster
| Project/Area Number |
25462454
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Sakai Atsushi 日本医科大学, 医学部, 講師 (30386156)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAKE Koichi 日本医科大学, 医学部, 准教授 (90267211)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 神経障害性疼痛 / マイクロRNA / クラスター / 一次感覚神経 |
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| Outline of Final Research Achievements |
Neuropathic pain remains a major clinical problem and thus development of effective and safe therapy for the pain is awaited. miR-17-92 cluster microRNAs are critical for chronic neuropathic pain. These microRNAs are predicted to target many genes, some of which are indeed responsible for neuropathic pain. Drugs modifying these gene function exerted potent analgesia. Therefore, miR-17-92 may provide an opportunity for development of neuropathic pain therapy.
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Report
(3 results)
Research Products
(8 results)
