Functional analysis of FOXA1 in castration resistant prostate cancer and development of nomogram
Project/Area Number |
25462469
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Chiba University |
Principal Investigator |
Sakamoto Shinichi 千葉大学, 医学(系)研究科(研究院), 助教 (70422235)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | Castration Resistance / Prostate Cancer / Androgen Receptor / Testosterone / FOXA1 / Transporter / Tumor Volume / 前立腺癌 / アンドロゲン受容体 / 去勢抵抗性 |
Outline of Final Research Achievements |
Through the immunohistochemical analysis, we have reported over expression of FOXA1 cause short time before acquire castration resistance. We have identified overexpression of aminoacid transporter; LAT1 in castration resistant prostate cancer and reporterd anti-androgen therapy incraese LAT1 expression, thus reported singificance of LAT1 in novel castration resistant mechanism(J Urol 2016). Through the analyisis of prostate cancer patients received hormonal therapy, we have identified testosterone 20ng/dL was the significant prognostic factor. Thus proposed testosterone 20ng/dL should be the ideal castration level in prostate cancer patients during hormonal therapy(J Urol 2015).
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer.2016
Author(s)
Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, Seki N.
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Journal Title
Cancer Sci.
Volume: 107
Issue: 1
Pages: 84-94
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Nadir Testosterone after Long-Term Followup Predicts Prognosis in Patients with Prostate Cancer Treated with Combined Androgen Blockade.2015
Author(s)
Kamada S, Sakamoto S, Ando K, Muroi A, Fuse M, Kawamura K, Imamoto T, Suzuki H, Nagata M, Nihei N, Akakura K, Ichikawa T.
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Journal Title
Journal of Urology
Volume: 194
Issue: 5
Pages: 1264-70
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer.2015
Author(s)
Kato M, Goto Y, Matsushita R, Kurozumi A, Fukumoto I, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, Seki N.
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Journal Title
International Journal of Oncology
Volume: 47
Issue: 2
Pages: 710-718
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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