Development of the selective hyperthermia for the bone metastasis of prostate cancer using anti RANKL antibody-binding nanoparticles
| Project/Area Number |
25462496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Nagata Daisuke 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (20336689)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Noriyasu 名古屋市立大学, 大学院医学研究科, 講師 (20254279)
KOHRI Kenjiro 名古屋市立大学, 学長 (30122047)
ANDO Ryosuke 名古屋市立大学, 大学院医学研究科, 助教 (30381867)
ETANI Toshiki 名古屋市立大学, 大学院医学研究科, 研究員 (30600754)
TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
内木 拓 名古屋市立大学, 医学(系)研究科(研究院), 助教 (50551272)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 温熱治療 / 磁性ナノ粒子 / 前立腺癌 / 骨転移 / 前立腺癌骨転移 / 抗体結合磁性微粒子 / RANKL / 経静脈注入 / 骨転移治療 |
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| Outline of Final Research Achievements |
We developed the new hyperthermic therapy (Magnetic induced intra cellular hyperthermia) which generate heat by magnetic nano particle: MNP). We connected an antibody of RANKL (nuclear factor kappa-B ligand) which became the key to exacerbation of prostate cancer bone metastases to MNP and gave it transvenously subsequently. And we studied in vitro and in vivo for the purpose of performing hyperthermia for bone invasion lesion after arriving of MNP at bone invasion lesion. It was confirmed that anti RANKL antibody-binding MNP significantly adhered to mouse osteoblasts MC3T3-E1 where RANKL was present in in vitro. Anti RANKL antibody-binding MNP were injected into rat prostate cancer bones invasion models transvenously.
We were not able to examine confirming the effect of the hyperthermia.
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Report
(3 results)
Research Products
(1 results)
