Novel biomarker and therapeutic target in the targeted therapy for the patients with metastatic renal cell cancer
Project/Area Number |
25462504
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Japanese Foundation for Cancer Research |
Principal Investigator |
Takeshi Yuasa 公益財団法人がん研究会, その他部局等, 研究員 (00314162)
|
Co-Investigator(Renkei-kenkyūsha) |
Takahiro Isono 滋賀医科大学, 実験実習支援センター, 准教授 (20176259)
Yuichi Ishikawa (公財)がん研究会, がん研究所病理センター, センター長 (80222975)
Yonese Junji (公財)がん研究会有明病院, 泌尿器科, 部長 (70469633)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 腎癌 / 分子標的治療 / 次世代シーケンサー / 遺伝子発現 / 糖枯渇 / 腎がん / 治療耐性 / VHL遺伝子 / 腎細胞がん / 血管新生阻害剤 / グルコース枯渇 / 小胞体ストレス |
Outline of Final Research Achievements |
Resistance to the targeted therapy is emerging as an obstacle to successful cancer treatment. In this study, we investigated whether N-GlcNAc2-modified proteins induce G2/M arrest and cell death under glucose deprivation in renal cell cancer (RCC), which is sensitive to nutritional stress. Four of seven RCC cell lines produced N-GlcNAc2-modified proteins and led G2/M arrest under glucose deprivation, leading to cell death. The remaining three cell lines did not produce N-GlcNAc2-modified proteins and undergo G1/S arrest, leading to survival. In this study, we demonstrated that the RCC cells which accumulate N-GlcNAc2-modified proteins do not survive with abnormally prolonged unfolded protein response (UPR) pathway. By contrast, cells that do not accumulate N-GlcNAc2-modified proteins survive. Further studies to clarify these findings will lead to the development of novel targeted therapy for RCC.
|
Report
(3 results)
Research Products
(15 results)
-
-
[Journal Article] The International Metastatic Renal Cell Carcinoma Database Consortium model as a prognostic tool in patients with metastatic renal cell carcinoma previously treated with first-line targeted therapy: a population-based study.2015
Author(s)
Ko JJ, Xie W, Kroeger N, Lee JL, Rini BI, Knox JJ, Bjarnason GA, Srinivas S, Pal SK, Yuasa T, Smoragiewicz M, Donskov F, Kanesvaran R, Wood L, Ernst DS, Agarwal N, Vaishampayan UN, Rha SY, Choueiri TK, Heng DY.
-
Journal Title
Lancet Oncol.
Volume: 16
Issue: 3
Pages: 293-300
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Characteristics of Long-term and Short-term Survivors of Metastatic Renal Cell Carcinoma Treated with Targeted Therapies: Results from the International mRCC Database Consortium.2015
Author(s)
Fay AP, Xie WL, Lee LC, Harshman LC, Bjarnason GA, Knox SE, Wood L, Vaishamayan UN, Yuasa T, Tan MH, Rha SY, Donskov F, Agarwa N, Kollmannsberger CK, North SA, Rini BI, Choueiri TK, Heng DYC
-
Journal Title
Clinical Genitourinary Cancer
Volume: 13
Issue: 2
Pages: 150-155
DOI
Related Report
Peer Reviewed
-
[Journal Article] Outcome of Patients With Metastatic Sarcomatoid Renal Cell Carcinoma: Results From the International Metastatic Renal Cell Carcinoma Database Consortium.2015
Author(s)
Kyriakopoulos CE, Chittoria N, Choueiri TK, Kroeger N, Lee JL, Srinivas S, Knox JJ, Bjarnason GA, Ernst SD, Wood LA, Vaishampayan UN, Agarwal N, Pal SK, Kanesvaran R, Rha SY, Yuasa T, Donskov F, North SA, Heng DY, Rini BI.
-
Journal Title
Clin Genitourin Cancer
Volume: 13
Issue: 2
Pages: e79-e85
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Clinical response to induction chemotherapy predicts improved survival outcome in urothelial carcinoma with clinical lymph nodal metastasis treated by consolidative surgery.2015
Author(s)
Urakami S, Yuasa T, Yamamoto S, Sakura M, Tanaka H, Hayashi T, Uehara S, Inoue Y, Fujii Y, Masuda H, Fukui I, Yonese J.
-
Journal Title
Int J Clin Oncol.
Volume: 20
Issue: 6
Pages: 1171-1178
DOI
Related Report
-
-
[Journal Article] The Impact of Low Serum Sodium on Treatment Outcome of Targeted Therapy in Metastatic Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Cancer Database Consortium.2014
Author(s)
Schutz FA, Xie W, Donskov F, Sircar M, McDermott DF, Rini BI, Agarwal N, Pal SK, Srinivas S, Kollmannsberger C, North SA, Wood LA, Vaishampayan U, Tan MH, Mackenzie MJ, Lee JL, Rha SY, Yuasa T, Heng DY, Choueiri TK
-
Journal Title
Eur Urol.
Volume: 65
Issue: 4
Pages: 723-30
DOI
Related Report
Peer Reviewed
-
[Journal Article] Outcomes of patients with metastatic renal cell carcinoma that do not meet eligibility criteria for clinical trials.2014
Author(s)
Heng DY, Choueiri TK, Rini BI, Lee J, Yuasa T, Pal SK, Srinivas S, Bjarnason GA, Knox JJ, Mackenzie M, Vaishampayan UN, Tan MH, Rha SY, Donskov F, Agarwal N, Kollmannsberger C, North S, Wood LA.
-
Journal Title
Ann Oncol
Volume: 25
Issue: 1
Pages: 149-54
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Metastatic non clear cell renal cell carcinoma (nccRCC) treated with targeted therapy agents: Characterization of survival outcome and application of the International mRCC Database Consortium (IMDC) Criteria.2013
Author(s)
Kroeger N, Xie W, Lee JL, Bjarnason GA, Knox JJ, Mackenzie MJ, Wood L, Srinivas S, Vaishamayan UN, Rha SY, Pal SK, Yuasa T, Donskov F, Agarwal N, Kollmannsberger CK, Tan MH, North SA, Rini BI, Choueiri TK, Heng DY.
-
Journal Title
Cancer
Volume: 119
Issue: 16
Pages: 2999-3006
DOI
Related Report
Peer Reviewed
-