Analyzing the possible involvement of anti-Müllerian hormon and anti-Müllerian hormon receptor II single nucleotide polymorphism in infertility
| Project/Area Number |
25462581
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Ohmichi Masahide 大阪医科大学, 医学部, 教授 (10283764)
Terai Yoshito 大阪医科大学, 医学部, 講師 (90278531)
Tanabe Akiko 大阪医科大学, 医学部, 助教 (70454543)
Hayashi Atushi 大阪医科大学, 医学部, 助教 (80411338)
Hayashi Masami 大阪医科大学, 医学部, 助教 (00551748)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ＡＭＨ / AMH: 146 T>G / -482 A>G / IVS1+149 T>A / IVS5-6 C>T / ＡＭＨＲ / 抗ミュウラー管ホルモン / 子宮内膜症 / 不妊 / 体外受精 / 一塩基多型 / ＳＮＰ / AMH １４６T>G / AMHRII+１４９ T>A / ISV10+77 A>G / ISV５−６ C>T / Genotyping assay |
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| Outline of Final Research Achievements |
In this study, -482 A>G homozygote mutation was associated with ISV5-6 C>T homozygote mutation, and the oocyte retrieval rate of -482 A>G homozygote mutation was statistically lower than in the control group and in other SNPs, despite the result that total dose of hMG/FSH for oocyte retrieval in -482A>G homozygote mutation cases showed no statistical difference compared with the wild type. These results suggest that -482 A>G homozygote mutation could cause poor follicular development. In the normal pregnancy group, all cases of -482 A>G homozygote mutation were associated with ISV5-6 and showed poor obstetric outcome. In conclusion, additional replication and functional studies are necessary to secure definite conclusions as to the effect of AMHRII -482 A>G polymorphism on infertility and obstetric outcome. However, this study revealed the possible involvement of AMHRII -482 A>G polymorphism on the malfunction of follicular development in Japanese women.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Analysis of the methylation rate of the androgen receptor promoter region in granulosa cells in moderate to severe endometriosis patients undergoing controlled ovarian hyperstimulation2015
Author(s)
Yoko Nakamura, M.D., Yoshiki Yamashita, M.D., Natsuho Saito, M.D., Hikaru Yamamoto M.D., Masami Hayashi, M.D. Yoshito Terai, M.D., Masahide Ohmichi, M.D.
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Journal Title
Journal of Reproductive Endocrinology & Infertility
Volume: 1
Pages: 1-5
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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