| Project/Area Number |
25462581
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Ohmichi Masahide 大阪医科大学, 医学部, 教授 (10283764)
Terai Yoshito 大阪医科大学, 医学部, 講師 (90278531)
Tanabe Akiko 大阪医科大学, 医学部, 助教 (70454543)
Hayashi Atushi 大阪医科大学, 医学部, 助教 (80411338)
Hayashi Masami 大阪医科大学, 医学部, 助教 (00551748)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ＡＭＨ / AMH: 146 T>G / -482 A>G / IVS1+149 T>A / IVS5-6 C>T / ＡＭＨＲ / 抗ミュウラー管ホルモン / 子宮内膜症 / 不妊 / 体外受精 / 一塩基多型 / ＳＮＰ / AMH １４６T>G / AMHRII+１４９ T>A / ISV10+77 A>G / ISV５−６ C>T / Genotyping assay |
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| Outline of Final Research Achievements |
In this study, -482 A>G homozygote mutation was associated with ISV5-6 C>T homozygote mutation, and the oocyte retrieval rate of -482 A>G homozygote mutation was statistically lower than in the control group and in other SNPs, despite the result that total dose of hMG/FSH for oocyte retrieval in -482A>G homozygote mutation cases showed no statistical difference compared with the wild type. These results suggest that -482 A>G homozygote mutation could cause poor follicular development. In the normal pregnancy group, all cases of -482 A>G homozygote mutation were associated with ISV5-6 and showed poor obstetric outcome. In conclusion, additional replication and functional studies are necessary to secure definite conclusions as to the effect of AMHRII -482 A>G polymorphism on infertility and obstetric outcome. However, this study revealed the possible involvement of AMHRII -482 A>G polymorphism on the malfunction of follicular development in Japanese women.
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