Elucidation of novel molecules involved in the MET and disseminated in ovarian cancer peritoneal metastasis

• Project/Area Number: 25462620
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka Medical College
• Principal Investigator: KANEMURA MASANORI 大阪医科大学, 医学部, 非常勤講師 (40298782)
• Co-Investigator(Kenkyū-buntansha): Ohmichi Masahide 大阪医科大学, 医学部, 教授 (10283764) ; Terai Yoshito 大阪医科大学, 医学部, 准教授 (90278531) ; Tanabe Akiko 大阪医科大学, 医学部, 非常勤講師 (70454543) ; Tsunetoh Satoshi 大阪医科大学, 医学部, 助教 (70388255) ; Tanaka Yoshimichi 大阪医科大学, 医学部, 助教 (10625502)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 卵巣癌 / 腹膜播種 / MMT / EMT / HGF / 中皮―間葉転換 / 中皮-間葉転換

Outline of Final Research Achievements

A current working model for the metastatic process of ovarian carcinoma suggests that cancer cells are shed from the ovarian tumor into the peritoneal cavity and attach to the layer of mesothelial cells that line the inner surface of the peritoneum, and several studies suggest that hepatocyte growth factor (HGF) plays an important role in the dissemination of ovarian cancer. The in vivo and in vitro experimental models revealed that HGF secreted by ovarian cancer cells induces the MMT and stimulates the invasion of mesothelial cells. Furthermore, manipulating the HGF activity affected the degree of dissemination and ascites formation. Finaly, we demonstrated that HGF secreted by ovarian cancer cells plays an important role in cancer peritoneal implantation (Gynecologic Oncology 139: 345-354, 2015).

Research Products

• [Journal Article] Estradiol-mediated hepatocyte growth factor is involved in the implantation of endometriotic cells via the mesothelial-mesenchymal transition in the peritoneum. (2015)
  • Author(s): Ono YJ, Hayashi M, Tanabe A, Hayashi A, Kanemura M, Terai Y, Ohmichi M.
  • Journal Title: Am J Physiol Endocrinol Metab. Volume: Apr 7 Issue: 11 Pages: E950-E959
  • DOI: 10.1152/ajpendo.00573.2014
  • Peer Reviewed / Open Access
• [Journal Article] Hepatocyte growth factor secreted by ovarian cancer cells stimulates peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum (2015)
  • Author(s): Michihiko Nakamura, Yoshihiro J Ono, Masanori Kanemura, Tomohito Tanaka, Masami Hayashi, Yhoshito Terai, Masahide Ohmichi
  • Journal Title: Gynecologic Oncology Volume: 139 Issue: 2 Pages: 345-354
  • DOI: 10.1016/j.ygyno.2015.08.010
  • Peer Reviewed / Int'l Joint Research