Investigation of pathology of sensorineural hearing loss from redox state and inflammatory cytokines and application for treatment

• Project/Area Number: 25462634
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nagoya University
• Principal Investigator: Teranishi Masaaki 名古屋大学, 医学系研究科, 准教授 (20335037)
• Co-Investigator(Kenkyū-buntansha): 中島 務 国立研究開発法人国立長寿医療研究センター, その他部局等, 研究員 (30180277)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 難聴 / レドックス / 内耳性難聴 / 遺伝子多型 / 酸化ストレス

Outline of Final Research Achievements

Because genetic factors may contribute partly to the etiologies of inner ear diseases, we investigated the association between genetic polymorphisms located in genes related to the free-radical process or inflammatory pathway and susceptibility to sudden deafness. We found that NOS 3 and uncoupling protein 2 polymorphisms were significantly associated with the risk of sudden deafness.

Research Products

• [Journal Article] Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease (2013)
  • Author(s): Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Suzuki H, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T
  • Journal Title: Free Radic Res Volume: 47 Issue: 6-7 Pages: 498-506
  • DOI: 10.3109/10715762.2013.793319
• [Journal Article] Association between polymorphisms in genes encoding methylenetetrahydrofolate reductase and the risk of Meniere's disease (2013)
  • Author(s): Huang Y, Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Sone M, Sugiura S, Ando F, Shimokata H, Nakashima T
  • Journal Title: J Neurogenet Volume: 27 Issue: 1-2 Pages: 5-10
  • DOI: 10.3109/01677063.2013.770510
• [Journal Article] Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss. (2013)
  • Author(s): Mariko Shimono, Masaaki Teranishi, Tadao Yoshida, Masahiro Kato, Rui Sano, Hironao Otake, Ken Kato, Michihiko Sone, Naoki Ohmiya, Shinji Naganawa, Tsutomu Nakashima
  • Journal Title: Otol Neurotol. Volume: 34(7) Issue: 7 Pages: 1241-1246
  • DOI: 10.1097/mao.0b013e3182990e81
  • Peer Reviewed
• [Presentation] POLYMORPHISMS IN GENES IN PATIENTS WITH MENIERE’S DISEASE (2016)
  • Author(s): Masaaki Teranishi, Yasue Uchida, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Michihiko Sone, Saiko Sugiura, Fujiko Ando, Hiroshi Shimokata and Tsutomu Nakashima
  • Organizer: 53rd Inner Ear Biology Workshop
  • Place of Presentation: MONTPELLIER, FRANCE
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] メニエール病における遺伝子多型の検討 (2015)
  • Author(s): 寺西正明、内田育恵、加藤 健、大竹宏直、吉田忠雄、西尾直樹、曾根三千彦、杉浦彩子、中島 務
  • Organizer: 第２５回日本耳科学会
  • Place of Presentation: 長崎県、長崎市（長崎ブリックホール）
  • Year and Date: 2015-10-07
• [Presentation] POLYMORPHISMS IN GENES INVOLVED IN OXIDATIVE STRESS IN PATIENTS WITH MENIERE'S DISEASE (2015)
  • Author(s): Masaaki Teranishi, Yasue Uchida, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Michihiko Sone, Saiko Sugiura, Fujiko Ando, Hiroshi Shimokata and Tsutomu Nakashima
  • Organizer: 52nd Inner Ear Biology Workshop
  • Place of Presentation: Rome, イタリア
  • Year and Date: 2015-09-12
  • Int'l Joint Research
• [Presentation] 突発性難聴における遺伝子多型の検討 (2015)
  • Author(s): 寺西正明、小出悠介、内田育恵、加藤 健、大竹宏直、吉田忠雄、西尾直樹、 曾根三千彦、杉浦彩子、安藤富士子、下方浩史、中島 務
  • Organizer: 第２４回 愛知県難聴・耳鳴に関する懇話会
  • Place of Presentation: 名古屋市（エーザイ 株式会社 名古屋 CO 6 階ホール）
  • Year and Date: 2015-04-11
• [Presentation] 突発性難聴・メニエール病における酸化ストレス関連の遺伝子多型の検討 (2013)
  • Author(s): 寺西正明、内田育恵、西尾直樹、加藤 健、大竹宏直、吉田忠雄、鈴木宏和、曾根三千彦、杉浦彩子、安藤富士子、下方浩史、中島 務
  • Organizer: 第66回 日本酸化ストレス学会
  • Place of Presentation: ウィンク愛知（名古屋市）
• [Presentation] 突発性難聴における酸化ストレス関連の遺伝子多型の検討 (2013)
  • Author(s): 寺西正明、内田育恵、加藤 健、大竹宏直、吉田忠雄、杉浦彩子、曾根三千彦、中島 務
  • Organizer: 第58回日本聴覚医学会
  • Place of Presentation: ホテル ブエナビスタ（松本市）
• [Presentation] メニエール病における酸化ストレス関連の遺伝子多型の検討 (2013)
  • Author(s): 寺西正明、加藤 健、大竹宏直、吉田忠雄、中島 務
  • Organizer: 第72回 日本めまい平衡医学会
  • Place of Presentation: 大阪国際交流センター（大阪市）