| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we evaluated the role of mast cell in the development of eosinophilic chronic rhinosinusitis (ECRS). We reported that the number of mast cell infiltrated in epithelium of ECRS were significantly increased compared to control tissue. Furthermore, expression pattern of mast cell intrinsic proteases were different from previously reported type. This changes were confirmed by using primary cultured mast cell stimulated by cytokines from airway epithelial cell. We concluded that this type of mast cells were involved in the development of the ECRS pathogenesis.
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