Role of mast cell in the development of eosinophilic chronic rhinosinusitis

• Project/Area Number: 25462660
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of Fukui
• Principal Investigator: Takabayashi Tetsuji 福井大学, 医学部附属病院, 講師 (70397272)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 好酸球性副鼻腔炎 / 肥満細胞 / 好酸球 / Tryptase / Chymase / 線維化 / 創傷治癒 / Carboxypeptidase A3 / 鼻茸 / 気道上皮 / IL-33

Outline of Final Research Achievements

In this study, we evaluated the role of mast cell in the development of eosinophilic chronic rhinosinusitis (ECRS). We reported that the number of mast cell infiltrated in epithelium of ECRS were significantly increased compared to control tissue. Furthermore, expression pattern of mast cell intrinsic proteases were different from previously reported type. This changes were confirmed by using primary cultured mast cell stimulated by cytokines from airway epithelial cell. We concluded that this type of mast cells were involved in the development of the ECRS pathogenesis.

Research Products

• [Journal Article] Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen (2015)
  • Author(s): Imoto Y, Takabayashi T, Sakashita M, Tokunaga T, Ninomiya T, Ito Y, Narita N, Yamada T, Fujieda S
  • Journal Title: Immun Inflamm Dis Volume: 3 Issue: 3 Pages: 300-308
  • DOI: 10.1002/iid3.69
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced cisplatin resistance in human maxillary cancer cells (2015)
  • Author(s): Ito Y, Narita N, Nomi N, Sugimoto C, Takabayashi T, Yamada T, Karaya K, Matsumoto H, Fujieda S
  • Journal Title: Sci Rep Volume: 21 Issue: 1 Pages: 12360-12360
  • DOI: 10.1038/srep12360
  • Peer Reviewed / Open Access
• [Journal Article] Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease (2015)
  • Author(s): Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, Takabayashi T, Norton JE, Hulse KE, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Kato A, Harris KE, Carter RG, Fujieda S, Kern RC, Schleimer RP
  • Journal Title: Am J Respir Crit Care Med Volume: 192 Issue: 6 Pages: 682-694
  • DOI: 10.1164/rccm.201412-2278oc
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC Study. (2015)
  • Author(s): Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Yamada K, Okano M, Ohtori N, Yoshikawa M, et al
  • Journal Title: Allergy Volume: Epub ahead of print Issue: 8 Pages: 995-1003
  • DOI: 10.1111/all.12644
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Factors associated with the development and remission of allergic diseases in an epidemiological survey of high school students in Japan. (2015)
  • Author(s): Tokunaga T, Ninomiya T, Osawa Y, Imoto Y, Ito Y, Takabayashi T, Narita N, Kijima A, Murota H, Katayama I, Fujieda S.
  • Journal Title: Am J Rhinol Allergy. Volume: 29 Issue: 2 Pages: 94-9
  • DOI: 10.2500/ajra.2015.29.4135
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M. Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice (2015)
  • Author(s): Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M
  • Journal Title: Journal of Controlled Release Volume: 200 Pages: 52-59
  • DOI: 10.1016/j.jconrel.2014.12.040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chronic Rhinosinusitis and the Coagulation System (2015)
  • Author(s): Kim DY, Cho SH, Takabayashi T, Schleimer RP
  • Journal Title: Allergy Asthma Immunol Res Volume: 52 Issue: 5 Pages: 421-430
  • DOI: 10.4168/aair.2015.7.5.421
  • Peer Reviewed / Open Access
• [Journal Article] Cross-talk between human mast cells and bronchial epithelial cells in plasminogen activator inhibitor-1 production via transforming growth factor-β1. (2015)
  • Author(s): Cho SH, Lee SH, Kato A, Takabayashi T, Kulka M, Shin SC, Schleimer RP.
  • Journal Title: Am J Respir Cell Mol Biol Volume: 52 Issue: 1 Pages: 88-95
  • DOI: 10.1165/rcmb.2013-0399oc
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps (2016)
  • Author(s): 高林哲司
  • Organizer: 16th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: 東京
  • Year and Date: 2016-03-28
• [Presentation] 好酸球性副鼻腔炎の診断（JESREC study)と病態メカニズムに基づいた新規治療法の開発 (2016)
  • Author(s): 高林哲司
  • Organizer: 第94回 大分耳鼻咽喉科臨床研究会
  • Place of Presentation: 大分
  • Year and Date: 2016-02-25
  • Invited
• [Presentation] 鼻副鼻腔粘膜の領域特異性からみた鼻茸形成メカニズムの検討 (2016)
  • Author(s): 高林哲司
  • Organizer: 第34回 日本耳鼻咽喉科 免疫アレルギー学会
  • Place of Presentation: 三重
  • Year and Date: 2016-02-04
• [Presentation] 凝固系制御異常による好酸球性副鼻腔炎の病態形成メカニズムに関する検討 (2015)
  • Author(s): 高林哲司
  • Organizer: 第54回 日本鼻科学会総会・学術講演会
  • Place of Presentation: 広島
  • Year and Date: 2015-10-01
• [Presentation] 好酸球性副鼻腔炎の病態形成における肥満細胞の役割 (2013)
  • Author(s): 高林 哲司
  • Organizer: 第２５回 日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Invited
• [Presentation] Excessive fibrin deposition caused by a fibrinolytic disorder associated with reduction of tissue plasminogen activator expression in nasal polyps (2013)
  • Author(s): Tetsuji Takabayashi
  • Organizer: The 16th Asian Research Symposium in Rhinology
  • Place of Presentation: Tokyo, Japan, KEIO PLAZA Hotel
• [Presentation] 線溶系制御異常による慢性副鼻腔炎の病態形成メカニズムに関する検討 (2013)
  • Author(s): 高林 哲司
  • Organizer: 第５２回日本鼻科学会学術講演会
  • Place of Presentation: 福井、フェニックスプラザ
  • Invited
• [Presentation] The binding of plasminogen activator-1 and tissue plasminogen activator promotes less fibrosis and excessive fibrin deposition in nasal polyp tissue (2013)
  • Author(s): Tetsuji Takabayashi
  • Organizer: 7th International symposium on recent advances in rhinosinusitis and nasal polyposis
  • Place of Presentation: Shimane, Japan、くにびきメッセ
• [Presentation] 好酸球性副鼻腔炎の病態形成メカニズムにおける線溶系制御の検討 (2013)
  • Author(s): 高林 哲司
  • Organizer: 第63回 日本アレルギー学会秋季臨床大会
  • Place of Presentation: 東京、ホテルニューオータニ
  • Invited
• [Presentation] 肥満細胞の多様性と好酸球性副鼻腔炎に関する検討 (2013)
  • Author(s): 高林 哲司
  • Organizer: 第63回 日本アレルギー学会秋季臨床大会
  • Place of Presentation: 東京、ホテルニューオータニ
  • Invited
• [Book] Bio Clinica 慢性炎症と疾患 (2016)
  • Author(s): 高林哲司
  • Total Pages: 5
  • Publisher: 北隆館