The development of tailor-made treatment for high-grade salivary gland cancer
| Project/Area Number |
25462672
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KANO SATOSHI 北海道大学, 大学病院, 助教 (00374421)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 唾液腺癌 / 唾液腺導管癌 / HER2 / トラスツズマブ / 頭頸部外科学 / EGFR / c-KIT / 免疫染色法 / FISH |
|---|
| Outline of Final Research Achievements |
We analyzed the expression of proteins in salivary gland cancer. The results showed that the expression of EGFR, HER2 and c-KIT was 76%, 20% and 38%, respectively. Among them, the patients with HER2-positive tumors had significantly unfavorable prognosis. Furthermore, we found the activation of the PI3K pathway in HER2-positive tumors. HER2 was mainly overexpressing in salivary duct carcinoma, and was detected more frequently in carcinoma ex pleomorphic adenoma than in de novo tumors. This result suggested that HER2 could be involved in carcinogenesis from pleomorphic adenoma. Based on these results, we planned to develop a HER2-targeted therapy in salivary gland cancer.
|
Report
(4 results)
Research Products
(17 results)
-
[Journal Article] Effect of local extension sites on survival in locally advanced maxillary sinus cancer.2014
Author(s)
Kano S, Hayashi R, Homma A, Matsuura K, Kato K, Kawabata K, Monden N, Hasegawa Y, Onitsuka T, Fujimoto Y, Iwae S, Okami K, Matsuzuka T, Yoshino K, Fujii M.
-
Journal Title
Head Neck.
Volume: 36
Issue: 11
Pages: 1567-1572
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Matched-pair analysis in patients with advanced oropharyngeal cancer: surgery versus concurrent chemoradiotherapy.2013
Author(s)
Kano S, Homma A, Hayashi R, Kawabata K, Yoshino K, Iwae S, Hasegawa Y, Nibu K, Kato T, Shiga K, Matsuura K, Monden N, Fujii M.
-
Journal Title
Oncology
Volume: 84
Issue: 5
Pages: 290-298
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
