Fundamental research for novel treatment of glossodynia

• Project/Area Number: 25462682
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: Ishida Yusuke 大阪大学, 医学(系)研究科(研究院), 講師 (30381809)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Shoichi 大阪大学, 医学系研究科, 教授 (20216063) ; NAKAMURA Yukiko 大阪大学, 医学系研究科, 助教 (90548083) ; KONDO Makoto 大阪大学, 医学系研究科, 助教 (50633012)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 舌痛症

Outline of Final Research Achievements

The cause of glossodynia is unclear and there is no good treatment for the sickness at present.
We performed fundamental research to establish novel treatment of glossodynia. Interestingly, it was indicated that one candidate gene of mechanosensor is especially expressed in the mandibular nerve area of trigeminal ganglion. This gene is perhaps expressed in the area because of that plays an important role in glossodynia. We progressed our research under hypothesis that there is some kind of relation between the mechanosensor and the gene related in pain, if the sensor is mediated in glossodynia, and had some good results.

Research Products

• [Remarks] 大阪大学大学院医学系研究科・医学部
  • URL: http://www.med.osaka-u.ac.jp/